Handbook of Sleep Research

Dr. Dringenberg is professor in the Department of Psychology and the Centre for Neuroscience Studies at Queen’s University, Kingston, Ontario, Canada. He took up his position at Queen’s after completing a Ph.D. in Neuroscience at the University of Western Ontario, Canada, and a post-doctoral fellowship at the Institute of Physiological Psychology, University of Duesseldorf, Germany. Over the last 20 years, research in Dr. Dringenberg’s Neuroplasticity Laboratory has examined the role of various sleep-wake-related neuromodulators in controlling the electrical activity and synaptic plasticity of the neocortex and hippocampus in animal models. Recently, his lab has expanded its focus to also investigate the role of sleep and waking states in memory consolidation in humans. Dr. Dringenberg’s work has been funded by the Natural Sciences and Engineering Research Council of Canada (NSERC); he is the author of more than 80 peer-reviewed publications.

"Everyone is fascinated by sleep yet we do not understand its real contribution to our lives. If you are really interested in what we know and what we should know about sleep, the Handbook of Sleep Research (edited by Hans Dringenberg), is your source. It is a comprehensive volume covering wide range of topics from sleep in sea mammals to humans, from the contribution of sleep in memory to brain homeostasis. Each chapter is written by an expert in the field. This volume should be on the shelf of all sleep researchers and, in fact, many neuroscientists interested in the default state of the brain."--György Buzsáki, M.D., Ph.D. Biggs Professor of Neurocience, New York University, Langone Medical Center (author of the Rhythms of the Brain; The Brain from Inside Out)

• Theme A: Brain activity during sleep and waking1. Neuronal activity during the sleep-wake cycle2. Timing and topography of sleep onset: asynchronies and regional changes of brain activity3. Local patterns of sleep and wakefulness4. Hippocampal information processing and homeostatic regulation during REM and non-REM sleepTheme B: Regulation of Waking and Sleeping5. The circuit, cellular and synaptic bases of sleep-wake regulation6. Hypocretin and the regulation of sleep-wake transitions7. Serotonergic systems in sleep and waking 8. Adenosinergic control of sleep/wake behavior9. NREM sleep regulation from neuronal assembly to ion10. Neurobiological mechanism of non-REM sleep11. The genetic regulation of human sleep-wake rhythms and patterns12. Circadian and homeostatic regulation of sleep 13. The role of glia in sleep-wake regulation and function 14. Interactions between sleep and breathing15. Neurobiological parallels, overlaps and divergences of sleep & anaesthesiaTheme C: REM Sleep and Dreaming16. Neuroanatomical and neurochemical systems involved in REM sleep generation17. Functions and circuits of REM sleep18. Structural and functional differences in brain mechanisms of dream recall19. Consciousness and meta-consciousness during sleepTheme D: Evolution, Cross-Cultural and Comparative Approaches, and Novel Model Systems20. Evolution of sleep and adaptive sleeplessness21. Hunter-gatherer sleep and novel human sleep adaptations22. Sleep in Drosophila 23. Sleep, immunity, and stress: novel insights from Drosophila24. Sleep in fish models25. Sleep in aquatic mammals26. The role of sleep in song learning processes in songbirdTheme E: Sleep, Plasticity, and Memory27. Sleep and brain development 28. Sleep and plasticity29. Sleep-wake and cortical synaptic plasticity30. Sleep stages and neural oscillations: A window into sleep’s role in memory consolidation and cognitive abilities31. Cued memory reactivation: A tool to manipulate memory consolidation during sleep 32. Sleep and memory consolidation: conceptual and methodological challengesTheme F: Sleep, Emotion, and Motivation33. The role of sleep in processing emotional information 34. Sleep and emotions: on sleep, emotional memories and depression35. Motivational processes in the regulation of sleep/wake statesTheme G: Disturbed Sleep36. The effects of sleep loss on brain functioning 37. Physiological and neurobehavioural consequences of chronic sleep restriction in rodent models38. Imaging of the sleep disordered brain39. Sleep impact on perception, memory, and emotion in adults and the effects of early life experience40. Sleep and driving41. Drug discovery and emerging treatments for sleep disorders42. Insomnia pharmacotherapies: pharmacodynamics, strategies, new directions, and key measures in clinical trial investigationsTheme H: Sleep in Aging and Disease 43. Sleep and aging: circadian influences44. Sleep, physical activity, and cognitive health in older adults45. Sleep in normal aging, Alzheimer’s disease and mild cognitive impairment 46. Sleep in major depression47. Closing the loop between circadian rhythms, sleep and attention deficit hyperactivity disorder 48. Dissecting brain circuitry for sleep disorder narcolepsy in murine models 49. Rapid Eye Movement Sleep Behavior Disorder: Pathological neural circuits and association with Parkinson's Disease