Dosage Form Design Considerations

Dr Rakesh K Tekade, Assistant Professor of the Department of Pharmaceutics, investigates the design, development and characterization of targeted nanotechnology based formulations for the site specific delivery of therapeutic drugs, siRNA, microRNA, plasmids, proteins and peptide for the treatment of cancer. His current research encompasses development of novel polymeric nanomaterial for effective cytosolic delivery of anticancer bioactives. Dr Tekade’s research is focused on designing a new generation of nanoparticles, which could identify the cancer cells and selectively deliver anticancer drugs and genes to inhibit the growth of cancer while sparing healthy tissues. His research work involves the applications of polymer chemistry, nanotechnology, molecular biology, pharmacokinetics/pharmacodynamics and imaging techniques. Dr Tekade has over 70 publications, 01 patent, 7 book chapters, and 3 editorial articles. He has delivered several invited research talks and presented research finding in more than 30 scientific conferences.

• 1. Preformulation in drug research and pharmaceutical product development2. Physicochemical aspects to be considered in Pharmaceutical Product Development3. Role of physicochemical parameters on drug absorption and their Implications in Pharmaceutical Product Development 4. Physiologic Factors Related to Drug Absorption5. Physico-chemical, pharmaceutical and biological considerations in GIT Absorption of drugs6. Influence of Drug Properties and Routes of Drug Administration on the design of controlled release systems7. Drug stability and degradation studies8. First pass metabolism considerations in Pharmaceutical Product Development9. Dissolution profile considerations during Pharmaceutical Product Development10. Drug disposition considerations in Pharmaceutical Product Development11. Protein and tissue binding: Implication on pharmacokinetic parameters 12. Preformulation studies of drug substances, proteins and peptides: Role in drug discovery and Pharmaceutical Product Development13. Role of salt selection in drug discovery and development14. Drug Complexation: Implications in drug solubilization and oral bioavailability enhancement15. Solubility and solubilization approaches in Pharmaceutical Product Development16. Rheology and its implications on performance of liquid dosage forms17. Micromeritics in Pharmaceutical Product Development18. Four stages in Pharmaceutical Product Development – Preformulation – Prototype development - Biological aspects - Scale up studies – Commercialization  19. Scale up studies in Pharmaceutical Product Development20. Manipulation of physiological processes for Pharmaceutical Product Development21. Impact of pharmaceutical product Quality on Clinical Efficacy22. Formulation additives used in Pharmaceutical Products: Emphasis on regulatory perspectives and GRAS