Nucleic Acid Sensing and Immunity, Part A

Claire Vanpouille-Box received her Ph.D. in Experimental Pharmacology in 2011 from the University of Angers, France. Determined to pursue an academic career and intrigued by the emerging role of radiation in cancer immunotherapy, she decided to join the lab of Dr. Demaria in 2011 to conduct her postdoctoral training. Claire is currently holding a junior faculty position as an instructor in radiation oncology at Weill Cornell Medicine where she is focusing her research to study the mechanisms whereby radiation therapy can convert a tumor into an in situ individualized vaccine. In particular, Claire is leveraging her multidisciplinary background to better understand how radiation should be administered to induce anti-tumor immunity. She has published 28 articles in peer-reviewed scientific journals and have received many prestigious awards among which the 2014-Marie Curie Award from the Radiation Research Society (RRS), the 2015-AACR Susan G Komen Scholar-in-training award from the American Association for Cancer Research (AACR) and the 2017-AAI Early Career Faculty travel grant from the American Association of Immunologists (AAI).

• 1. Molecular bases of discrimination between self from non-self nucleic acidsTaro Kawai2. Intracellular RNA sensing in mammalian cellsNikolai Khodarev3. Nuclear DNA damage and nucleic acid sensingFabrizio Ensoli4. Negative regulation of nucleic acid sensingSagi Shapira5. Dendritic cells responses to exogenous nucleic acidsStefania Gallucci6. Activating the nucleic acid-sensing machinery for anticancer immunityMichael Gough7. Nucleic acid sensing and inflammasomesParas Anand