Principles of Nucleic Acid Structure

Stephen Neidle is an Emeritus Professor of Chemical Biology at University College London, where he has also been the Director of Research in the School of Pharmacy. He has published over 500 primary papers and reviews and is a principal inventor on 14 patent filings. He has also written and edited several books on nucleic acids and anti-cancer drugs. Mark Sanderson is a Visiting Professor of Biophysics in the Dept of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London. Recent structural studies in his laboratory have centred on type-II topoisomerase–DNA–drug complexes in collaboration with Prof. Mark Fisher’s group at St. George’s University of London using cryo-EM and X-ray crystallography, and the study of novel nucleic acid–protein complexes.

• 1. Methods for Studying Nucleic Acid Structure2. The Building-Blocks of DNA and RNA3. DNA Structure as Observed in Fibers and Crystals4. Non-standard and Higher-Order DNA Structures: DNA–DNA Recognition5. Principles of Small Molecule–DNA Recognition6. RNA Structures and Their Diversity7. Principles of Protein–DNA Recognition8. RNA Binding Proteins