Dr Gunnar F. Nordberg, MD, PhD, is an emeritus Professor at Umea University, Umea, Sweden, where he served as chairman of the Department of Environmental and Occupational Medicine for many years. He has also worked as a Professor and chair at the Department of Environmental Medicine, Odense University, Denmark and for periods of a year at the International Agency for Research on Cancer, Lyon, France and the University of North Carolina and the National Institute of Environmental Health Sciences, NC, USA. In his capacity as university professor, he tutored many PhD and master students in Environmental medicine, a number of them from countries around the world. He has published more than 300 papers in Scientific Journals and International Handbooks. In addition, he authored, edited or co-edited 24 Scientific Books and participated in International Task Groups evaluating Risks of Environmental Agents, which resulted in 30 international books or reports. Some of these publications resulted from his activities as a chairman of the Scientific Committee on the Toxicology of Metals, International Commission on Occupational Health. He is presently the Task Group Chairman of Cadmium Risk Assessment in the Toxicology and Risk Assessment Group of the International Union of Pure and Applied Chemistry. His Scientific Publications are mainly on Toxicology and Epidemiology of environmental agents, particularly metals and the application of such data for Human Risk Assessment. He has coordinated EU- projects on Environmental Epidemiology and Toxicology of Metals and participated as an active scientist in several such projects. He has been the principal investigator of many research projects funded by Swedish funding Agencies and is presently actively involved in such research. He is one of the editors of a Textbook in Swedish “Arbets- och Miljömedicin”, latest 4th edition 2019. Chief Editor, Handbook on the Toxicology of Metals, 5th Ed, published 2021 by Academic Press/Elsevier. He has extensive experience as an expert serving Swedish and International Authorities, such as the Swedish National Board of Health (Socialstyrelsen), Japan Food Safety Agency, US Environmental Protection Agency, National Institute of Environmental Health Sciences (NIEHS), Agency for Toxic Substances and Disease Registry (ATSDR) USA, World Health Organization HQ, Geneva/International Program on Chemical Safety/WHO Commission on Health and the Environment, Energy Panel; International Agency for Research on Cancer IARC, Lyon, France, Europe/European Environment Agency, Copenhagen; European Medicines Agency, London; European Food Safety Authority (EFSA), Parma, Italy. Professor Max Costa's research interests include molecular mechanisms of metal carcinogenesis, cancer, pharmacology, epigenetics, and chromatin structure. Dr. Costa has published over 380 papers and has authored a book on Metal Carcinogenesis Testing. He serves on the Editorial Board as an Associate Editor for the Elsevier Journal, Toxicology and Applied Pharmacology.

• 1. Toxicology of metals: Overview, definitions, concepts, and trends2. General chemistry of metals, sampling, analytical methods, and speciation3. Exposure, dose, and toxicokinetics of metals4. Toxicity of metal and metal oxide nanoparticles5. Toxicity of metals released from implanted medical devices6. Metals and air pollution7. Toxic metals in food8. Interaction of toxic metals with the gut microbiome9. Biological monitoring of metals and biomarkers10. Computational modeling and dosimetry of metals11. Selected molecular mechanisms of metal toxicity and carcinogenicity12. Effects of metals on extracellular vesicle signaling13. General considerations of dose-effect and dose-response relationships14. Interactions and mixtures in metal toxicology15. Gene-Environment interactions and metal toxicity16. Epidemiological approaches to metal toxicology17. Essential metals: assessing risks from deficiency and toxicity18. The interaction of metals and the skin: the good, bad, and the ugly19. Metals and the respiratory tract20. Neurotoxicology of metals21. Metals and cardiovascular disease22. Renal effects of exposure to metals23. Carcinogenicity of metal compounds24. Immunotoxicology of metals25. Effects of metallic elements on reproduction and development26. Ecotoxicology of metals-sources, transport, and effects on the ecosystem27. Risk assessment for metal exposures28. Diagnosis and treatment of metal poisoning general aspects29. Principles for prevention of the toxic effects of metals30. Metal toxicology in low-income and lower-middle-income countries

Dr Gunnar F. Nordberg, MD, PhD, is an emeritus Professor at Umea University, Umea, Sweden, where he served as chairman of the Department of Environmental and Occupational Medicine for many years. He has also worked as a Professor and chair at the Department of Environmental Medicine, Odense University, Denmark and for periods of a year at the International Agency for Research on Cancer, Lyon, France and the University of North Carolina and the National Institute of Environmental Health Sciences, NC, USA. In his capacity as university professor, he tutored many PhD and master students in Environmental medicine, a number of them from countries around the world. He has published more than 300 papers in Scientific Journals and International Handbooks. In addition, he authored, edited or co-edited 24 Scientific Books and participated in International Task Groups evaluating Risks of Environmental Agents, which resulted in 30 international books or reports. Some of these publications resulted from his activities as a chairman of the Scientific Committee on the Toxicology of Metals, International Commission on Occupational Health. He is presently the Task Group Chairman of Cadmium Risk Assessment in the Toxicology and Risk Assessment Group of the International Union of Pure and Applied Chemistry. His Scientific Publications are mainly on Toxicology and Epidemiology of environmental agents, particularly metals and the application of such data for Human Risk Assessment. He has coordinated EU- projects on Environmental Epidemiology and Toxicology of Metals and participated as an active scientist in several such projects. He has been the principal investigator of many research projects funded by Swedish funding Agencies and is presently actively involved in such research. He is one of the editors of a Textbook in Swedish “Arbets- och Miljömedicin”, latest 4th edition 2019. Chief Editor, Handbook on the Toxicology of Metals, 5th Ed, published 2021 by Academic Press/Elsevier. He has extensive experience as an expert serving Swedish and International Authorities, such as the Swedish National Board of Health (Socialstyrelsen), Japan Food Safety Agency, US Environmental Protection Agency, National Institute of Environmental Health Sciences (NIEHS), Agency for Toxic Substances and Disease Registry (ATSDR) USA, World Health Organization HQ, Geneva/International Program on Chemical Safety/WHO Commission on Health and the Environment, Energy Panel; International Agency for Research on Cancer IARC, Lyon, France, Europe/European Environment Agency, Copenhagen; European Medicines Agency, London; European Food Safety Authority (EFSA), Parma, Italy. Professor Max Costa's research interests include molecular mechanisms of metal carcinogenesis, cancer, pharmacology, epigenetics, and chromatin structure. Dr. Costa has published over 380 papers and has authored a book on Metal Carcinogenesis Testing. He serves on the Editorial Board as an Associate Editor for the Elsevier Journal, Toxicology and Applied Pharmacology.

• 1. Toxicology of metals: Overview, definitions, concepts, and trends2. General chemistry of metals, sampling, analytical methods, and speciation3. Exposure, dose, and toxicokinetics of metals4. Toxicity of metal and metal oxide nanoparticles5. Toxicity of metals released from implanted medical devices6. Metals and air pollution7. Toxic metals in food8. Interaction of toxic metals with the gut microbiome9. Biological monitoring of metals and biomarkers10. Computational modeling and dosimetry of metals11. Selected molecular mechanisms of metal toxicity and carcinogenicity12. Effects of metals on extracellular vesicle signaling13. General considerations of dose-effect and dose-response relationships14. Interactions and mixtures in metal toxicology15. Gene-Environment interactions and metal toxicity16. Epidemiological approaches to metal toxicology17. Essential metals: assessing risks from deficiency and toxicity18. The interaction of metals and the skin: the good, bad, and the ugly19. Metals and the respiratory tract20. Neurotoxicology of metals21. Metals and cardiovascular disease22. Renal effects of exposure to metals23. Carcinogenicity of metal compounds24. Immunotoxicology of metals25. Effects of metallic elements on reproduction and development26. Ecotoxicology of metals-sources, transport, and effects on the ecosystem27. Risk assessment for metal exposures28. Diagnosis and treatment of metal poisoning general aspects29. Principles for prevention of the toxic effects of metals30. Metal toxicology in low-income and lower-middle-income countries