"...this scholarly and rigorous treatise of presynaptic inhibition will prove valuable to anyone exploring the depths of synaptic integration."--The Quarterly Review of Biology"Overall, this book is well-written and nicely produced. The list of authors is impressive and certainly represents leaders in the field. The editors have also done a good job in achieving a relatively uniform style among the different chapters and the cross-references between the different chapters are quite helpful." - Dr. Robert Chen, The Canadian Journal of Neurological Sciences

• Introduction ; Part I: Basic Mechanisms of Presynaptic Control ; 1. Anatomical Basis for Presynaptic Inhibition on Primary Sensory Fibers ; 2. Chloride Transport, Osmotic Balance and Presynaptic Inhibition ; 3. Mechanisms and Physiological Implications of Receptor-Mediated Inhibition of Voltage-Dependent Ca2+ Channels ; 4. Presynaptic Inhibition and Faciliation of Transmitter Release ; 5. Primary Afferent Depolarization and Presynaptic Inhibition ; 6. Control of Action Potential Invasion into Terminal Arborizations ; 7. Action Potential Propagation Along Primary Afferents and Presynaptic Inhibition in Clarkes's Column of the Spinal Cord ; 8. Two Types of Inhibition in the Spinal Cord ; 9. The Relative Contributions of GABAA and GABB Receptors to Presynaptic Inhibition of Group Ia EPSPs ; 10. Modulation of Transmitter Release From Ia Afferents by Their Preceding Activity - A 'Post-activation Depression' ; 11. Presynaptic Inhibition of Neuromuscular Transmission in Crayfish ; 12. Regulation of Primary Eighth Nerve Synapses on the Mauthner Cell ; 13. Some Unanswered Questions About the Mechanisms and Function of Presynaptic Inhibition ; Part II: Presynaptic Control of Segmental Inputs ; 14. Presynaptic Inhibition and the Anatomy of Group Ia Afferents ; 15. Ia Fiber Architecture: Implications for the Functional Role of Presynaptic Inhibition ; 16. Dynamic Aspects of Presynaptic Function in the Developing Mammalian Spinal Cord ; 17. Selectivity of the Presynaptic Control of Synaptic Effectiveness of Group 1 Afferents in the Mammalian Spinal Cord ; 18. Presynaptic Inhibition Can Act as a Filter of Input from Tendon Organs during Muscle Contraction ; 19. Neuronal Systems Involved in Modulation Synaptic Transmission from Group II Muscle Afferents ; 20. Presynaptic Inhibition of Synaptic Transmssion from Sensory, Intemeuronal and Supraspinal Neurons to Spinal Target Cells in Lamprey ; 21. Differential Control of Presynaptic Inhibition of Ia Terminals during Voluntary Movement in Humans ; 22. PAD and Modulation of Evoked Group II Flexion Reflexes during MLR-Evoked Fictive Locomotion ; 23. Presynaptic Mechanisms during Locomotion ; 24. Modulation of Excitatory Perineal Reflexes and Sacral Striated Motoneuron during Micturition in the Cat ; 25. A Contribution of Dorsal Root Reflexes to Peripheral Inflammation ; 26. Modulation of Nociceptive Information at the Presynaptic Terminals of Primary Afferent Fibers ; Bibliography ; Index