"This book has many strengths. It is very weel written in a clear, persuasive style. The enthusiam and depth of knowledge that Gregg Semenza has for his subject is evident in every chapter.... The referencing is also very well judged, being both selective and comprehensive." --Human Genetics"...this book will be very useful to two diverse audiences. Clinicians will be stimulated by the many examples and suggestions provided, and hopefully will look at their patients who have congenital and hereditary defects from a different perspctive. Molecular biologists will be intrigued by the transcriptional phenomena hidden behind a particular phenotype. This book represents an important example of how medical sciences and molecular biology may interactprofitably."--Nature Medicine"The most useful chapters of the book are those...organized by transcription factor family....Students of human biology will find this material accessible, useful, and remarkably thorough...."--CELL

• Part I: Transcriptional Regulation ; 1. Gene Expression and Transcriptional Regulation ; 2. Cis-acting Transcriptional Regulatory Elements ; 3. Trans-acting Factors ; Part II: Transcriptional Pathophysiology ; 4. Mutations in Cis-acting Transcriptional Regulatory Elements ; 5. Mutations in Genes Encoding Transcription Factors: The Nuclear Receptor Superfamily ; 6. Other Zinc-Finger Proteins: WT1 and GL13 ; 7. PAX Proteins ; 8. bHLH Proteins ; 9. Homeodomain Proteins ; 10. HMG Domain Proteins ; 11. POU Domain Proteins ; 12. Other Transcriptional Factor Families ; 13. Co-activators ; 14. General Transcription Factors ; 15. Somatic Cell Genetic Disease: Cancer ; 16. Epidenetic Disease: Teratogenesis

"This book has many strengths. It is very weel written in a clear, persuasive style. The enthusiam and depth of knowledge that Gregg Semenza has for his subject is evident in every chapter.... The referencing is also very well judged, being both selective and comprehensive." --Human Genetics"...this book will be very useful to two diverse audiences. Clinicians will be stimulated by the many examples and suggestions provided, and hopefully will look at their patients who have congenital and hereditary defects from a different perspctive. Molecular biologists will be intrigued by the transcriptional phenomena hidden behind a particular phenotype. This book represents an important example of how medical sciences and molecular biology may interactprofitably."--Nature Medicine"The most useful chapters of the book are those...organized by transcription factor family....Students of human biology will find this material accessible, useful, and remarkably thorough...."--CELL

• Part I: Transcriptional Regulation ; 1. Gene Expression and Transcriptional Regulation ; 2. Cis-acting Transcriptional Regulatory Elements ; 3. Trans-acting Factors ; Part II: Transcriptional Pathophysiology ; 4. Mutations in Cis-acting Transcriptional Regulatory Elements ; 5. Mutations in Genes Encoding Transcription Factors: The Nuclear Receptor Superfamily ; 6. Other Zinc-Finger Proteins: WT1 and GL13 ; 7. PAX Proteins ; 8. bHLH Proteins ; 9. Homeodomain Proteins ; 10. HMG Domain Proteins ; 11. POU Domain Proteins ; 12. Other Transcriptional Factor Families ; 13. Co-activators ; 14. General Transcription Factors ; 15. Somatic Cell Genetic Disease: Cancer ; 16. Epidenetic Disease: Teratogenesis