"The editors have assembled a fascinatingly diverse set of contributions by leading experts on topics ranging from sequence analysis, structural studies, and expression analysis to exploring molecular interaction networks, their influence on phenotypes, and their applications to fundamental problems such as physiology, development, and evolution. These two volumes provide a well-timed and reasonably comprehensive account of major areas in the emerging subjectof systems biology."--The Quarterly Review of Biology

• 1. Mass Spectrometry in Systems Biology 3 ; 2. Mathematical Modeling and Optimization Methods for De Novo Protein Design 42 ; 3. Molecular Simulation and Systems Biology 67 ; 4. Global Gene Expression Assays: Quantitative Noise Analysis 103 ; 5. Mapping the Genotype-Phenotype Relationship in Cellular Signaling Networks: Building Bridges Over the Unknown 137 ; 6. Integrating Innate Immunity into a Global "Systems" Context: The Complement Paradigm Shift 169 ; 7. Systems Biotechnology: Combined in Silico and Omics Analyses for the Improvement of Microorganisms for Industrial Applications 193 ; 8. Genome-Scale Models of Metabolic and Regulatory Networks 232 ; 9. Biophysical Models of the Cardiovascular System 265 ; 10. Embryonic Stem Cells as a Module for Systems Biology 297 ; Index 319

"The editors have assembled a fascinatingly diverse set of contributions by leading experts on topics ranging from sequence analysis, structural studies, and expression analysis to exploring molecular interaction networks, their influence on phenotypes, and their applications to fundamental problems such as physiology, development, and evolution. These two volumes provide a well-timed and reasonably comprehensive account of major areas in the emerging subjectof systems biology."--The Quarterly Review of Biology

• 1. Mass Spectrometry in Systems Biology 3 ; 2. Mathematical Modeling and Optimization Methods for De Novo Protein Design 42 ; 3. Molecular Simulation and Systems Biology 67 ; 4. Global Gene Expression Assays: Quantitative Noise Analysis 103 ; 5. Mapping the Genotype-Phenotype Relationship in Cellular Signaling Networks: Building Bridges Over the Unknown 137 ; 6. Integrating Innate Immunity into a Global "Systems" Context: The Complement Paradigm Shift 169 ; 7. Systems Biotechnology: Combined in Silico and Omics Analyses for the Improvement of Microorganisms for Industrial Applications 193 ; 8. Genome-Scale Models of Metabolic and Regulatory Networks 232 ; 9. Biophysical Models of the Cardiovascular System 265 ; 10. Embryonic Stem Cells as a Module for Systems Biology 297 ; Index 319

"The editors have assembled a fascinatingly diverse set of contributions by leading experts on topics ranging from sequence analysis, structural studies, and expression analysis to exploring molecular interaction networks, their influence on phenotypes, and their applications to fundamental problems such as physiology, development, and evolution. These two volumes provide a well-timed and reasonably comprehensive account of major areas in the emerging subjectof systems biology."--The Quarterly Review of Biology

• 1. Mass Spectrometry in Systems Biology 3 ; 2. Mathematical Modeling and Optimization Methods for De Novo Protein Design 42 ; 3. Molecular Simulation and Systems Biology 67 ; 4. Global Gene Expression Assays: Quantitative Noise Analysis 103 ; 5. Mapping the Genotype-Phenotype Relationship in Cellular Signaling Networks: Building Bridges Over the Unknown 137 ; 6. Integrating Innate Immunity into a Global "Systems" Context: The Complement Paradigm Shift 169 ; 7. Systems Biotechnology: Combined in Silico and Omics Analyses for the Improvement of Microorganisms for Industrial Applications 193 ; 8. Genome-Scale Models of Metabolic and Regulatory Networks 232 ; 9. Biophysical Models of the Cardiovascular System 265 ; 10. Embryonic Stem Cells as a Module for Systems Biology 297 ; Index 319