Dopamine Handbook

Leslie L. Iversen, PhD, is Professor of Pharmacology at the University of Oxford, Oxford.Susan D. Iversen, PhD, is a Professor in the Department of Experimental Psychology at the University of Oxford, Oxford, UK Stephen B. Dunnett, PhD is a Professor in the School of Biosciences at Cardiff University, Cardiff, Wales, UK.Anders Björklund, MD, PhD, is a Professor at the Wallenberg Neuroscience Center Division of Neurobiology at Lund University in Lund, Sweden

"This is an authoritative and encyclopedic compendium of excellent reviews in dopamine research and brain function. There is no comparable book that contains this much information on a single neurotransmitter."--Doody's

• Contributors Chapter 1: Overview: A Personal View of the Dopamine Neuron in Historical Perspective Floyd E. Bloom Chapter 2: Neuroanatomy 2.1. Functional Neuroanatomy of Dopamine in the Striatum Charles R. Gerfen 2.2. Functional Implications of Dopamine D2 Receptor Localization in Relation to Glutamate Neurons Susan R. Sesack 2.3. Convergence of Limbic, Cognitive and Motor Cortico-striatal Circuits with Dopamine Pathways in Primate Brain Suzanne N. Haber 2.4. The Relationship between Dopaminergic Axons and Glutamatergic Synapses in the Striatum: Structural Considerations. J. Paul Bolam and Jonathan Moss Chapter 3: Molecular Pharmacology 3.1. Molecular Pharmacology of the Dopamine Receptors David R. Sibley, Michele L. Rankin, Lisa A. Hazelwood, R. Benjamin Free, Yoon Namkung, Elizabeth B. Rex, and Rebecca A. Roof 3.2. Role of Dopamine Transporters in Neuronal Homeostasis Marc G. Caron and Raul R. Gainetdinov 3.3. Intracellular Dopamine Signaling Gilberto Fisone 3.4. Ion Channels & Regulation of Neuronal Activity Birgit Liss and Jochen Roeper Chapter 4: Genes in Development 4.1.Genetic Control of Meso-diencephalic Dopaminergic Neuron Developments in Rodents Wolfgang Wurst and Nilima Prakash 4.2. Factors Shaping Later Stages of Dopamine Neuron Development Robert E. Burke 4.3. Postnatal Maturation of Dopamine Actions in the Prefrontal Cortex Patricio O'Donnell and Kuei Y. Tseng 4.4. Genetic Dissection of Dopamine Mediated Prefrontal-Striatal Mechanisms and Its Relationship to Schizophrenia Daniel Weinberger and Hao-Yang Tan Chapter 5: DA in Prefrontal Cortex and Cognition 5.1. From Behavior to Cognition: Functions of Mesostriatal, Mesolimbic and Mesocortical Dopamine Systems Trevor W. Robbins 5.2. Contributions of Mesocorticolimbic Dopamine to Cognition and Executive Function Stan B. Floresco 5.3. Dopamine's Influence on Prefrontal Cortical Cognition: Actions and Circuits of Behaving Primates Amy F.T. Arnsten, Susheel Vijayraghavan, Min Wang, Nao J. Gamo, and Constantinos D. Paspalas 5.4. Dopaminergic Modulation of Flexible Cognitive Control in Humans Mark D'Esposito and Roshan Cools 5.5. Neurocomputational analysis of DA Function Daniel Durstewitz Chapter 6: Ventral Striatum and Reward 6.1. Dopamine and Motor Function in Rat and Mouse Models of Parkinson's Disease Timothy Schallert and Sheila M. Fleming 6.2. Involvement of Nucleus Accumbens Dopamine in Behavioral Activation and Effort-related Functions John D. Salamone 6.3. Functional Heterogeneity in Striatal Subregions and Neurotransmitter Systems: Implications for Understanding the Neural Substrates Underlying Appetitive Motivation and Learning Brian A. Baldo and Matthew E. Andrzejewski 6.4. Behavioral Functions of Dopamine Neurons Philippe N. Tobler Chapter 7: Plasticity of Forebrain DA Systems 7.1. Dynamic Templates for Neuroplasticity in the Striatum Ann M. Graybiel 7.2. DA and Synaptic Plasticity in Mesolimbic Circuits Robert C. Malenka, F. Woodward Hopf, and Antonello Bonci 7.3. Dopaminergic Modulation of Striatal Glutamatergic Signaling in Health and Parkinson's Disease D. James Surmeier, Michelle Day, Tracy Gertler, Savio Chan, and Weixing Shen Chapter 8: DA Mechanisms in Addiction 8.1. The Role of Dopamine in the Motivational Vulnerability to Addiction George F. Koob and Michel Le Moal 8.2. Dopaminergic Mechanisms in Drug Seeking Habits and the Vulnerability to Drug Addiction Barry J. Everitt, David Belin, Jeffrey W. Dalley, and Trevor W. Robbins 8.3. Imaging Dopamine's Role in Drug Abuse and Addiction Nora D. Volkow, Joanna S. Fowler, Gene-Jack Wang, Frank Telang, and Ruben Baler Chapter 9: Parkinson's disease 9.1. Exploring the Myths about Parkinson's disease Yves Agid and Andreas Hartmann 9.2. Pathophysiology of L-DOPA-induced Dyskinesia in Parkinson's disease M. Angela Cenci 9.3. Progression of Parkinson's disease Revealed by Imaging Studies David J. Brooks 9.4. Transplantation of Dopamine Neurons: Extent and Mechanisms of Functional Recovery in Rodent Models of Parkinson's disease Stephen B. Dunnett and Anders Björklund 9.5. Clinical Experiences with Dopamine Neuron Replacement in Parkinson's disease. What is the Future? Olle Lindvall 9.6. Novel Gene-based Therapeutics Targeting the Dopaminergic System in Parkinson's disease Deniz Kirik, Jeffrey H. Kordower, Shilpa Ramaswamy, and Tomas Björklund 9.7. Neuroprotective Strategies in Parkinson's Disease C. Warren Olanow Chapter 10: Schizophrenia and Other Psychiatric Illnesses 10.1. Dopamine Dysfunction in Schizophrenia Anissa Abi-Dargham, Mark Slifstein, Larry Kegeles, and Marc Laruelle 10.2. Neuropharmacological Profiles of Antipsychotic Drugs Bryan L. Roth and Sarah C. Rogan 10.3. How Antipsychotics Work-Linking Receptors to Response Shitij Kapur and Nathalie Ginovart 10.4. Dopamine Dysfunction in Schizophrenia: From Genetic Susceptibility to Cognitive Impairment Andreas Meyer-Lindenberg, Heike Tost, and Shabnam Hakimi 10.5. The Role of Dopamine in the Pathophysiology and Treatment of Major Depressive Disorder Charles B. Nemeroff and Boadie W. Dunlop 10.6. DA Modulation of Forebrain Pathways and the Pathophysiology of Psychiatric Disorders Anthony A. Grace Index