Thalamocortical Assemblies

Sleep spindles, slow waves and epileptic discharges

AvAlain Destexhe,Terrence Sejknowski

Häftad, Engelska, 2023

Del i serien Monographs of the Physiological Society

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Beskrivning

During sleep, the mammalian brain generates an orderly progression of low frequency oscillations as the brain moves from sleep onset into deep sleep. This book explores the underlying neural mechanisms involved in generating these oscillations through interacting neural assemblies in the thalamus and the cortex. Sleep spindles are involved in the consolidation of experiences in long-term memory during sleep.Written by two leading experts in the field, this book integrates the properties of ion channels, synaptic interactions, and intrinsic cellular mechanisms into biophysical models of neural oscillations in local circuits and distributed networks. In particular, the book focuses on sleep spindles and how they are highjacked by epileptic seizuresReissued in paperback after being unavailable for many years, this revised edition of Thalamocortical Assemblies includes updates to each chapter, highlighting developments since its first publication. The book will be valuable to neuroscientists, neurobiologists, physiologists and computational researchers interested in sleep and memory processes.

Produktinformation

Utgivningsdatum:2023-12-13
Mått:170 x 240 x 23 mm
Vikt:952 g
Format:Häftad
Språk:Engelska
Serie:Monographs of the Physiological Society
Antal sidor:512
Förlag:OUP OXFORD
ISBN:9780198864998

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Mer om författaren

Alain Destexhe is a Professor and Research Director at the CNRS (French National Center for Scientfic Research). He is Vice Director of the Paris-Saclay Institute of Neuroscience (NeuroPSI), one of the largest Neuroscience research institutes in France, and he is also the founder and director of the European Institute of Theoretical Neuroscience (EITN). He is a specialist of electrophysiology and computational neuroscience, and his research team studies brain states in general, such as the wake-sleep cycle, anesthesia, epilepsy and states of minimal consciousness. These subjects are investigated using a mix of experimental data and computational approaches, from mice to humans.Terrence Sejnowski is a pioneer in Computational Neuroscience and recipient of the 2022 International Gruber Prize in Neuroscience. He is the Francis Crick Chair at The Salk Institute for Biological Studies and a Distinguished Professor at the University of California, San Diego, where he a co-director of the Institute for Neural Computation. He is also the President of the Neural Information Processing Systems (NeurIPS) Foundation, which organizes the largest annual conference on artificial intelligence. He is a member of the National Academy of Sciences, the National Academy of Engineering, the National Academy of Medicine, and the National Academy of Inventors.

Recensioner i media

This handsome book is an elegant presentation of two decades of modeling of the electrical activity of the thalamocortical circuits of higher vertebrates. The subject is of great relevance to basic and clinical neuroscience. An excellent source for those wishing to understand and/or model the electrophysiology of thalamic neurons.

Innehållsförteckning

1: Introduction 2: Biophysical models of the membrane potential and ionic currents 3: Electrophysiological properties of thalamic relay neurons 4: Electrophysiological properties of thalamic reticular neurons 5: Biophysical models of synaptic interactions 6: Spindle oscillations in thalamic circuits 7: Spindle oscillations in the thalamocortical system 8: Thalamocortical mechanisms for spike-and-wave epileptic seizures 9: A physiological role for sleep oscillations