The fourth edition of the Textbook of Cancer Epidemiology offers a comprehensive overview of the global cancer burden, highlighting trends in incidence and mortality across time and regions. Foundational chapters address the history of the field, methodological approaches, and the role of biomarkers and genetics in cancer etiology. Twenty-four disease-specific chapters provide summaries of clinical characteristics, descriptive epidemiology, and established and emerging etiologic factors for individual malignancies. Authored by internationally recognized experts, the volume serves as an essential resource for scientists, clinicians, and public health professionals at all career stages.The new edition features updated global cancer burden estimates, extensively revised content reflecting ongoing advances in etiologic research, the latest findings in genetic and genomic determinants of cancer, and two new chapters on cancer screening and multiple myeloma. It also outlines promising directions for future research in cancer prevention and control.