Synthetic DNA Delivery Systems

Inbunden, Engelska, 2003

Del i serien Biotechnology Intelligence Unit

1 608 kr

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Beskrivning

DNA delivery into cells is a rapidly developing area in gene therapy and biotechnology. Moreover, it is a powerful research tool to determine gene structure, regulation, and function.Viral methods of DNA delivery are well-characterized and efficient, but little is known about the toxicity and immunogenecity of viral vectors. As a result, non-viral, transfection methods of DNA delivery are of increasing interest. Synthetic DNA Delivery Systems is a comprehensive and current resource on DNA transfection. The use of histidine-rich peptides and polypeptides as DNA delivery systems and self-assembled delivery systems based on cationic lipids and polymers are discussed. Targeted delivery to organelles, tumor cells and dendritic cells comprise an important topic.

Produktinformation

Utgivningsdatum:2003-09-30
Mått:155 x 235 x 13 mm
Vikt:401 g
Format:Inbunden
Språk:Engelska
Serie:Biotechnology Intelligence Unit
Antal sidor:135
Upplaga:2003
Förlag:Springer Science+Business Media
ISBN:9780306477010

Utforska kategorier

Biokemi inom Naturvetenskap och teknik
Biokemisk teknik inom Naturvetenskap och teknik

Innehållsförteckning

I: Introduction; D. Luo, W.M. Saltzman. II: Overcoming Cellular Barriers along the DNA Delivery Pathway. Outside of the cell: Supramolar assemblies of DNA delivery systems; Pitard. At the cell surface: Engineering the surface properties of synthetic gene delivery systems; Schaffer. Inside of the cell: Histidine containing peptides and polypeptides as nucleic acid vectors; Midoux. Intracellular targets for DNA delivery: nuclei and mitochondria; Torchilin. III: Targeted DNA Delivery. Immune cells: Mannose receptor-mediated gene delivery into antigen presenting dendritic cells; Zenke. Muscle: Electro-gene-transfer: a new approach for muscle gene delivery; Toniatti. Tumor: Tumor-targeted gene transfer with DNA polyplexes; Wagner. IV: Novel DNA Delivery Systems. Light: Photochemical transfection: a technology for efficient light directed gene delivery; Hogset. Ultrasound: Sonoportation: mechanical DNA delivery by ultrasonic cavitation; Miller, Greenleaf.