The Lung

Kent Pinkerton, MD, is professor of pediatrics, School of Medicine, and director of the Center for Health and the Environment at the University of California, Davis. His research focuses on the health effects of inhaled environmental air pollutants to alter respiratory, cardiovascular, and neurological structure and function. Special areas of interest include the interaction of gases and airborne particles to produce cellular and structural changes within site-specific regions and cells of the respiratory tract in both acute and chronic timeframes of exposure. Recent studies have focused on environmental and biological impacts of synthesized nanomaterials as well as the effects of environmental tobacco smoke and combustion particles on lung growth and development. He is associate director for the San Joaquin Aerosol Health Effects Research Center (SAHERC) to study airborne particles of the San Joaquin Valley. He is also the associate director for the Western Center for Agricultural Health and Safety (WCAHS) to study the health effects of airborne particles in an agricultural setting. Richard Harding is a NHMRC Senior Principal Research Fellow and an Emeritus Professor with the Department of Anatomy and Developmental Biology at Monash University, Australia. His research focuses on Respiratory Development and Programming. He is now semi-retired.

• Part I: Critical Events in Normal Development and Aging 1. Lung Progenitor Cell Specification and Morphogenesis2. Alveolar Development3. Development of the Innervation of the Lower Airways: Structure and Function4. Pulmonary Vascular Development5. Developmental Physiology of the Pulmonary Circulation6. Physical, Endocrine, and Growth Factors in Lung Development7. The Development and FUnction of the Pulmonary Surfactant System in Health, Prematurity, and Genetic Disease8. Ontogeny of the Pulmonary Immune System9. Macrophages and the Lung 10. Adaptation to Mechanical Signals in the Lung: Recruitment of Reserves, Remodeling, and Regrowth 11. Pulmonary Transition at Birth12. Normal Aging of the LungPart II: Environmental and Disease Influences on Lung Development and Aging 13. Epigenetics and the Developmental Origins of Lung Disease14. Pulmonary Consequences of Preterm Birth15. Preterm Birth and the Developing Lung: Programming Effects on Lung Structure and Function16. The Effects of Neonatal Hyperoxia on Lung Development17. Restricted Growth During Early Development: Effects on Lung Structure and Lung Function18. Cell-Based Strategies for the Treatment of Injury to the Developing Lung19. Effects of Environmental Tobacco Smoke during Early Life Stages20. Nicotine Exposure during Early Development: Effects on the Lung21. Implications of Early Life Exposures to Electronic Nicotine Delivery System (ENDS) Aerosols22. In Utero Exposure to Allergens and Development of the Allergic Phenotype in the Neonate23. Effect of Environment on the Developing and Adult Pulmonary Surfactant System and in the Aging Lung24. Environmental Determinants of Lung Aging25. The Role of Epigenetics in Lung Diseases and Environmental Exposures26. The Dynamic Microbiotal Changes in the Human: Impact on the Developing Lung27. Viral Respiratory Pathogens and Lung Injury in Pregnancy, with Focus on Epidemiology and Pathophysiology of ARDS amidst the COVID-19 Pandemic28. The Lung Exposome: Accelerating Precision Respiratory Health