Pain is a serious health problem. This book presents an intensive review of the anatomy, physiology, and pharmacology of the systems that mediate nociceptive processing. The authors cover areas that include anatomy, central and peripheral nerve processing, tissue and nerve injury states, as well as preclinical and clinical models of pain. Mechanisms of Pain also covers important clinical concepts, with specific emphasis on mechanisms of action. Written by world renowned global faculty, this book covers important areas of science required to understand pain medicine. Important topics covered include post–tissue and nerve injury pain states of primary afferents and the spinal cord. The authors also cover mechanisms of action of clinically relevant analgesics (opiates and non-opiates), psychological aspects of pain, pathophysiology of migraines, as well as the genetics of pain. This comprehensive book is to guide undergraduate, graduate, and clinicians in the field of pain medicine on important concepts related to the science and practice of pain.
