Use of Restricted Significance Tests in Clinical Trials

AvDavid S. Salsburg

Inbunden, Engelska, 1992

Del i serien Statistics for Biology and Health

550 kr

Beställningsvara. Skickas inom 10-15 vardagar. Fri frakt över 249 kr.

Fler format och utgåvor

Häftad

534 kr

Beskrivning

This thought-provoking book discusses the use of statistics in randomized clinical trials. Its aim is two-fold: firstly, it presents a clear account of the design and analysis of experiments in this setting which stresses the foundational issues involved. Secondly, the book seeks to develop the specific tools of analysis which can be derived from Neyman's model of restricted tests. The book is based on the author's many years of experience of clinical trials. Throughout, examples are used from a variety of types of study. As a result, all statisticians and research scientists who work on clinical trials will find this presentation clear and accessible, and very relevant to their own research interests.

Produktinformation

Utgivningsdatum:1992-08-06
Mått:155 x 235 x 15 mm
Vikt:453 g
Format:Inbunden
Språk:Engelska
Serie:Statistics for Biology and Health
Antal sidor:174
Upplaga:1992
Förlag:Springer-Verlag New York Inc.
ISBN:9780387977980

Utforska kategorier

Medicinsk utrustning och medicinska tekniker inom Medicin

Recensioner i media

"...A broad range of statistical methodologies is surveyed including restricted chi-square tests, normal theory tests, nonparametric tests, permutation and resampling methods and Bayesian estimation...For anyone who wants to think deeply about the basic issues involving the design and analysis of clinical trials, this book is a must read.."(Zentralblatt fur Mathematik)

Innehållsförteckning

One Philosophical and Scientific Problems when Applying Statistical Methods to Clinical Data.- 1 The Randomized Controlled Clinical Trial.- 2 Probability Models and Clinical Medicine.- 3 Significance Tests Versus Hypothesis Tests.- 4 Neyman’s Insights.- 5 Reconciling Fisher and Neyman.- Two Techniques for Applying Restricted Tests to Data from Randomized Controlled Clinical Trials.- 6 Continuous Measures Taken over Time.- 7 Combining Data Across Measures.- 8 Counts of Events.- 9 Permutation Tests and Resampling Techniques.- 10 Neyman’s Restricted Chi Square Tests.- 11 Miscellaneous Methods for Increasing Power.- 12 Bayesian Estimation.- 13 An Example of the Type of Analysis Suggested in This Book.- References.