Helen Irving is a Professor in Biomedical Sciences and is a member of the La Trobe Institute for Molecular Sciences (LIMS) in Melbourne, Australia. Helen's current research centers on understanding inflammatory signals at the molecular level to develop new and improved approaches to managing inflammatory conditions. Helen obtained her PhD in Biochemistry from The University of Melbourne and conducted post-doctoral work at Vanderbilt University (USA) and The University of Kentucky (USA) before returning to Australia to take up an ARC Post-Doctoral Fellowship at La Trobe University. For most of her career, she has been a teaching and research academic based at the Faculty of Pharmacy and Pharmaceutical Sciences at Monash University. Helen moved to the La Trobe Institute for Molecular Sciences (LIMS) at La Trobe University in 2017. Dr. Chris Gehring is based at the Università degli Studi di Perugia UNIPG, in the Department of Chemistry, Biology & Biotechnology. His research focuses on plant signalling peptides, with a focus on various peptide signalling molecules in development, defense, and homeostasis. He has published widely in such peer reviewed journals as Nature, Molecular Plant, Trends in Genetics, and the Journal of Biological Chemistry. Dr. Aloysius Wong earned a PhD in Bioscience from King Abdullah University of Science and Technology (KAUST), Saudi Arabia, as well as a MA in Biotechnology from the University of Cambridge, UK. In past positions, he has served as a post-doctoral researcher at the French National Centre for Scientific Research. Dr. Wong seeks to understand, from a molecular perspective, how plants, despite being sessile and immobile, can efficiently perceive environmental (biotic and abiotic) signals and launch short- and long-term biological responses that enable them to survive in environments considered hostile to plants. Dr. Wong has published widely in peer reviewed journals.

• 1. Introduction and overview of moonlighting enzymes in signal cascadesConstance Jeffery2. Extracellular vesicles enabling moonlighting proteinsPamali Fonseka, Sriram Gummadi, Akbar Lulu Marzan, Sai Vara Prasad Chitti, Suresh Mathivanan3. Eukaryotic moonlighting proteins that assist microbial infectionsMohd Akif4. Moonlighting proteins in neurobiology signaling mediated by G protein coupled receptors (GPCRs).Adrián Martínez Cortés, Mariana Mirchandani-Duque, Aracelis Hernández-García, Dasiel Oscar Borroto Escuela, Adam Danielson, Esther Berrocoso, Malak Choucri, Jose Laffita, Kjell Fuxe5. Metabolic enzymes co-opted in oncogenic signalingBailey Nance, Brian Keith, Marie Simon6. Metabolic enzymes moonlighting as RNA binding and regulatory proteinsConstance Jeffery7. Cryptic enzymes as fine tuners of signaling cascadesAloysius Wong, Helen Irving, Christoph Gehring8. Dual function plant cryptic nucleotide cyclasesMarcella Bracale, Maria Concetta de Pinto, Cecilia Lasorella, Eleonora David, Stefania Fortunato, Candida Vannini, Guido Domingo9. Crypto adenylate cyclases coming of ageAdriana Szmidt-Jaworska, Brygida Świeżawska10. Crypto adenylate cyclases moonlighting with phosphodiesterases in complex proteinsMateusz Kwiatkowski, Krzysztof Jaworski11. Gas sensing H-NOX hemo proteins in plants and beyondChuyun Bi, Christoph Gehring, Aloysius Wong12. Modulating the immune response via cryptic enzymesTrang Nguyen, Helen Irving, Cassandra Cianciarulo, Joseph Tucci, Ilona Turek13. Cryptic moonlighting enzymes enable crosstalk with other signaling moleculesJulia Davies14. Identifying hidden moonlighting proteins and protein regionsDaisuke Kihara15. Computational approaches and bioinformatic tools for the identification of cryptic enzymesShiyu Jiang, Aloysius Wong, Chuyun Bi16. Establishing cryptic enzyme interactomesIlona Turek, Santosh Ramabhadra Rao Tata, Helen Irving17. Assessing contributions of moonlighting proteins to signal cascadesJiri Friml, Linlin Qi18. Uncovering moonlighting proteins in cell organellesAnushka Date, Helen Irving, Santosh Ramabhadra Rao Tata

Helen Irving is a Professor in Biomedical Sciences and is a member of the La Trobe Institute for Molecular Sciences (LIMS) in Melbourne, Australia. Helen's current research centers on understanding inflammatory signals at the molecular level to develop new and improved approaches to managing inflammatory conditions. Helen obtained her PhD in Biochemistry from The University of Melbourne and conducted post-doctoral work at Vanderbilt University (USA) and The University of Kentucky (USA) before returning to Australia to take up an ARC Post-Doctoral Fellowship at La Trobe University. For most of her career, she has been a teaching and research academic based at the Faculty of Pharmacy and Pharmaceutical Sciences at Monash University. Helen moved to the La Trobe Institute for Molecular Sciences (LIMS) at La Trobe University in 2017. Dr. Chris Gehring is based at the Università degli Studi di Perugia UNIPG, in the Department of Chemistry, Biology & Biotechnology. His research focuses on plant signalling peptides, with a focus on various peptide signalling molecules in development, defense, and homeostasis. He has published widely in such peer reviewed journals as Nature, Molecular Plant, Trends in Genetics, and the Journal of Biological Chemistry. Dr. Aloysius Wong earned a PhD in Bioscience from King Abdullah University of Science and Technology (KAUST), Saudi Arabia, as well as a MA in Biotechnology from the University of Cambridge, UK. In past positions, he has served as a post-doctoral researcher at the French National Centre for Scientific Research. Dr. Wong seeks to understand, from a molecular perspective, how plants, despite being sessile and immobile, can efficiently perceive environmental (biotic and abiotic) signals and launch short- and long-term biological responses that enable them to survive in environments considered hostile to plants. Dr. Wong has published widely in peer reviewed journals.

• 1. Introduction and overview of moonlighting enzymes in signal cascadesConstance Jeffery2. Extracellular vesicles enabling moonlighting proteinsPamali Fonseka, Sriram Gummadi, Akbar Lulu Marzan, Sai Vara Prasad Chitti, Suresh Mathivanan3. Eukaryotic moonlighting proteins that assist microbial infectionsMohd Akif4. Moonlighting proteins in neurobiology signaling mediated by G protein coupled receptors (GPCRs).Adrián Martínez Cortés, Mariana Mirchandani-Duque, Aracelis Hernández-García, Dasiel Oscar Borroto Escuela, Adam Danielson, Esther Berrocoso, Malak Choucri, Jose Laffita, Kjell Fuxe5. Metabolic enzymes co-opted in oncogenic signalingBailey Nance, Brian Keith, Marie Simon6. Metabolic enzymes moonlighting as RNA binding and regulatory proteinsConstance Jeffery7. Cryptic enzymes as fine tuners of signaling cascadesAloysius Wong, Helen Irving, Christoph Gehring8. Dual function plant cryptic nucleotide cyclasesMarcella Bracale, Maria Concetta de Pinto, Cecilia Lasorella, Eleonora David, Stefania Fortunato, Candida Vannini, Guido Domingo9. Crypto adenylate cyclases coming of ageAdriana Szmidt-Jaworska, Brygida Świeżawska10. Crypto adenylate cyclases moonlighting with phosphodiesterases in complex proteinsMateusz Kwiatkowski, Krzysztof Jaworski11. Gas sensing H-NOX hemo proteins in plants and beyondChuyun Bi, Christoph Gehring, Aloysius Wong12. Modulating the immune response via cryptic enzymesTrang Nguyen, Helen Irving, Cassandra Cianciarulo, Joseph Tucci, Ilona Turek13. Cryptic moonlighting enzymes enable crosstalk with other signaling moleculesJulia Davies14. Identifying hidden moonlighting proteins and protein regionsDaisuke Kihara15. Computational approaches and bioinformatic tools for the identification of cryptic enzymesShiyu Jiang, Aloysius Wong, Chuyun Bi16. Establishing cryptic enzyme interactomesIlona Turek, Santosh Ramabhadra Rao Tata, Helen Irving17. Assessing contributions of moonlighting proteins to signal cascadesJiri Friml, Linlin Qi18. Uncovering moonlighting proteins in cell organellesAnushka Date, Helen Irving, Santosh Ramabhadra Rao Tata

Helen Irving is a Professor in Biomedical Sciences and is a member of the La Trobe Institute for Molecular Sciences (LIMS) in Melbourne, Australia. Helen's current research centers on understanding inflammatory signals at the molecular level to develop new and improved approaches to managing inflammatory conditions. Helen obtained her PhD in Biochemistry from The University of Melbourne and conducted post-doctoral work at Vanderbilt University (USA) and The University of Kentucky (USA) before returning to Australia to take up an ARC Post-Doctoral Fellowship at La Trobe University. For most of her career, she has been a teaching and research academic based at the Faculty of Pharmacy and Pharmaceutical Sciences at Monash University. Helen moved to the La Trobe Institute for Molecular Sciences (LIMS) at La Trobe University in 2017. Dr. Chris Gehring is based at the Università degli Studi di Perugia UNIPG, in the Department of Chemistry, Biology & Biotechnology. His research focuses on plant signalling peptides, with a focus on various peptide signalling molecules in development, defense, and homeostasis. He has published widely in such peer reviewed journals as Nature, Molecular Plant, Trends in Genetics, and the Journal of Biological Chemistry. Dr. Aloysius Wong earned a PhD in Bioscience from King Abdullah University of Science and Technology (KAUST), Saudi Arabia, as well as a MA in Biotechnology from the University of Cambridge, UK. In past positions, he has served as a post-doctoral researcher at the French National Centre for Scientific Research. Dr. Wong seeks to understand, from a molecular perspective, how plants, despite being sessile and immobile, can efficiently perceive environmental (biotic and abiotic) signals and launch short- and long-term biological responses that enable them to survive in environments considered hostile to plants. Dr. Wong has published widely in peer reviewed journals.

• 1. Introduction and overview of moonlighting enzymes in signal cascadesConstance Jeffery2. Extracellular vesicles enabling moonlighting proteinsPamali Fonseka, Sriram Gummadi, Akbar Lulu Marzan, Sai Vara Prasad Chitti, Suresh Mathivanan3. Eukaryotic moonlighting proteins that assist microbial infectionsMohd Akif4. Moonlighting proteins in neurobiology signaling mediated by G protein coupled receptors (GPCRs).Adrián Martínez Cortés, Mariana Mirchandani-Duque, Aracelis Hernández-García, Dasiel Oscar Borroto Escuela, Adam Danielson, Esther Berrocoso, Malak Choucri, Jose Laffita, Kjell Fuxe5. Metabolic enzymes co-opted in oncogenic signalingBailey Nance, Brian Keith, Marie Simon6. Metabolic enzymes moonlighting as RNA binding and regulatory proteinsConstance Jeffery7. Cryptic enzymes as fine tuners of signaling cascadesAloysius Wong, Helen Irving, Christoph Gehring8. Dual function plant cryptic nucleotide cyclasesMarcella Bracale, Maria Concetta de Pinto, Cecilia Lasorella, Eleonora David, Stefania Fortunato, Candida Vannini, Guido Domingo9. Crypto adenylate cyclases coming of ageAdriana Szmidt-Jaworska, Brygida Świeżawska10. Crypto adenylate cyclases moonlighting with phosphodiesterases in complex proteinsMateusz Kwiatkowski, Krzysztof Jaworski11. Gas sensing H-NOX hemo proteins in plants and beyondChuyun Bi, Christoph Gehring, Aloysius Wong12. Modulating the immune response via cryptic enzymesTrang Nguyen, Helen Irving, Cassandra Cianciarulo, Joseph Tucci, Ilona Turek13. Cryptic moonlighting enzymes enable crosstalk with other signaling moleculesJulia Davies14. Identifying hidden moonlighting proteins and protein regionsDaisuke Kihara15. Computational approaches and bioinformatic tools for the identification of cryptic enzymesShiyu Jiang, Aloysius Wong, Chuyun Bi16. Establishing cryptic enzyme interactomesIlona Turek, Santosh Ramabhadra Rao Tata, Helen Irving17. Assessing contributions of moonlighting proteins to signal cascadesJiri Friml, Linlin Qi18. Uncovering moonlighting proteins in cell organellesAnushka Date, Helen Irving, Santosh Ramabhadra Rao Tata