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Helen Irving, Chris Gehring, Aloysius Wong - Cryptic Enzymes and Moonlighting Proteins, Häftad

Häftad, Engelska, 2025

Cryptic Enzymes and Moonlighting Proteins

Av Helen Irving, Chris Gehring, Aloysius Wong

Del i serien Foundations and Frontiers in Enzymology

1715 kr

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Beskrivning
Cryptic Enzymes and Moonlighting Proteins, a new volume in the Foundations and Frontiers in Enzymology series, offers a thorough overview of cryptic enzymes and moonlighting proteins in signaling cascades. In early chapters, leading international contributors discuss evolutionary considerations for moonlighting proteins, moonlighting interactions in the extracellular matrix, eukaryotic moonlighting proteins, modulating, moonlighting kinases, moonlighting proteins in neurobiology signaling, metabolic enzymes moonlighting as RNA binding and regulatory proteins. Later, methods-driven chapters discuss practical aspects of identifying hidden moonlighting domains in proteins, computational approaches and bioinformatic tools for the identification of cryptic enzymes, establishing cryptic enzyme interactomes, and assessing contributions of moonlighting proteins to signal cascades.

The book also explores recent advances in research and brings together an array of information across different fields to enable better targeting of these exciting proteins and their interactomes. With a clear focus on the role of moonlighting and cryptic enzymes in signal transduction, users will find examples of cryptic enzymes across species, as well as those in human healthy biology and pathogenesis.

  • Covers recent advances in our understanding of cryptic moonlighting proteins in signal cascades, highlighting and examining key themes across disciplines
  • Empowers researchers to better target cryptic enzymes and moonlighting proteins and their interactomes.
  • Features chapter contributions from international leaders in the field
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Helen Irving is a Professor in Biomedical Sciences and is a member of the La Trobe Institute for Molecular Sciences (LIMS) in Melbourne, Australia. Helen's current research centers on understanding inflammatory signals at the molecular level to develop new and improved approaches to managing inflammatory conditions. Helen obtained her PhD in Biochemistry from The University of Melbourne and conducted post-doctoral work at Vanderbilt University (USA) and The University of Kentucky (USA) before returning to Australia to take up an ARC Post-Doctoral Fellowship at La Trobe University. For most of her career, she has been a teaching and research academic based at the Faculty of Pharmacy and Pharmaceutical Sciences at Monash University. Helen moved to the La Trobe Institute for Molecular Sciences (LIMS) at La Trobe University in 2017. Dr. Chris Gehring is based at the Università degli Studi di Perugia UNIPG, in the Department of Chemistry, Biology & Biotechnology. His research focuses on plant signalling peptides, with a focus on various peptide signalling molecules in development, defense, and homeostasis. He has published widely in such peer reviewed journals as Nature, Molecular Plant, Trends in Genetics, and the Journal of Biological Chemistry. Dr. Aloysius Wong earned a PhD in Bioscience from King Abdullah University of Science and Technology (KAUST), Saudi Arabia, as well as a MA in Biotechnology from the University of Cambridge, UK. In past positions, he has served as a post-doctoral researcher at the French National Centre for Scientific Research. Dr. Wong seeks to understand, from a molecular perspective, how plants, despite being sessile and immobile, can efficiently perceive environmental (biotic and abiotic) signals and launch short- and long-term biological responses that enable them to survive in environments considered hostile to plants. Dr. Wong has published widely in peer reviewed journals.

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