A. Claudio Cuello works in the Department of Pharmacology and Therapeutics at McGill University in Montreal, Quebec, Canada.

• 1. The history of the CNS cholinergic transmission2. Organization of the basal forebrain cholinergic system in the human brain3. The cholinergic synapses4. Nicotinic acetylcholine receptors in the brain5. Cognition and modulation of the cholinergic system6. The involvement of the cholinergic system in Alzheimer disease7. Structural changes to the basal forebrain cholinergic system in the continuum of the Alzheimer’s pathology8. The dependence of basal forebrain cholinergic neurons on NGF: The case in Alzheimer pathology9. NGF based cholinergic therapies in Alzheimer disease10. Memory network and cognitive reserve are associated with preserved and stimulated cholinergic neurotransmission11. Cholinergic therapy in Alzheimer’s disease12. CNS muscarinic receptors agonists in Alzheimer’s disease treatment13. The Cholinergic system in down syndrome14. The Cholinergic system in Parkinson disease15. The Cholinergic system in dementia with Lewy bodies16. Epilogue. Standing on the shoulders of giants—Charting the future of cholinergic research

A. Claudio Cuello works in the Department of Pharmacology and Therapeutics at McGill University in Montreal, Quebec, Canada.

• 1. The history of the CNS cholinergic transmission2. Organization of the basal forebrain cholinergic system in the human brain3. The cholinergic synapses4. Nicotinic acetylcholine receptors in the brain5. Cognition and modulation of the cholinergic system6. The involvement of the cholinergic system in Alzheimer disease7. Structural changes to the basal forebrain cholinergic system in the continuum of the Alzheimer’s pathology8. The dependence of basal forebrain cholinergic neurons on NGF: The case in Alzheimer pathology9. NGF based cholinergic therapies in Alzheimer disease10. Memory network and cognitive reserve are associated with preserved and stimulated cholinergic neurotransmission11. Cholinergic therapy in Alzheimer’s disease12. CNS muscarinic receptors agonists in Alzheimer’s disease treatment13. The Cholinergic system in down syndrome14. The Cholinergic system in Parkinson disease15. The Cholinergic system in dementia with Lewy bodies16. Epilogue. Standing on the shoulders of giants—Charting the future of cholinergic research

A. Claudio Cuello works in the Department of Pharmacology and Therapeutics at McGill University in Montreal, Quebec, Canada.

• 1. The history of the CNS cholinergic transmission2. Organization of the basal forebrain cholinergic system in the human brain3. The cholinergic synapses4. Nicotinic acetylcholine receptors in the brain5. Cognition and modulation of the cholinergic system6. The involvement of the cholinergic system in Alzheimer disease7. Structural changes to the basal forebrain cholinergic system in the continuum of the Alzheimer’s pathology8. The dependence of basal forebrain cholinergic neurons on NGF: The case in Alzheimer pathology9. NGF based cholinergic therapies in Alzheimer disease10. Memory network and cognitive reserve are associated with preserved and stimulated cholinergic neurotransmission11. Cholinergic therapy in Alzheimer’s disease12. CNS muscarinic receptors agonists in Alzheimer’s disease treatment13. The Cholinergic system in down syndrome14. The Cholinergic system in Parkinson disease15. The Cholinergic system in dementia with Lewy bodies16. Epilogue. Standing on the shoulders of giants—Charting the future of cholinergic research