Biomechanics and Mechanobiology of Bone: From Model to Patient provides readers with a comprehensive overview of the modelling and assessment of bone biomechanics. It addresses topics such as biosubstitutes and bone implants from the point of view of design, properties, computational modeling, and choice of biomaterials. It concentrates on the biomechanics and mechanobiology modeling approaches of bone, including biological models, multiphysical approaches, surface and volumetric growth models, and bone fluid flow models. This is augmented by case studies and examples of models for computer-aided diagnosis, treatment, and monitoring of bone diseases. Readers are introduced to bone physiology, adaptation, and disease, including cellular aspects at the root of bone mechanotransduction and leading to bone growth and remodeling, and management of diseases. Chapters also cover the mechanical, multiphysical multiscale properties of bone and constitutive laws including bone viscoelasticity, poroelasticity, bone damage, fatigue and fracture, as well as measurement techniques of bone properties. - Offers a comprehensive reference for a multidisciplinary audience of researchers, engineers, computer scientists, and clinicians, focusing on the imaging and modeling of bone biomechanics- Presents all the components necessary to build realistic models for patient-centered assessments of bone fractures, damage and fatigue, biosubstitutes, and implants, as well as for broader clinical research- Explores computer-aided diagnosis, treatment and monitoring of bone diseases and conditions
