Diagnostic Pathology: Cytopathology

Dr. Vijayalakshmi Padmanabhan is a pathologist in Houston, Texas who specializes in cytopathology and surgical pathology at Houston Methodist Hospital as well as Houston Methodist West Hospital

Review of the previous edition: "This book is from the Elsevier Diagnostic Pathology series. In this particular volume, the series' characteristic high-yield and image-rich formatting is applied to the wide array of specimen types encountered in all realms of cytopathology."-- ©Doody’s Review Service, 2023, Madelyn Lew, M.D. (University of Michigan Medical School) Doody's Score: 5 Stars!

• SECTION 1: GYNECOLOGIC CYTOPATHOLOGYOVERVIEWPap Test and Cervical Cancer Screening: History and Reporting TerminologyCytopreparation, Instrumentation, and Automated Screening in Gynecologic CytologySpecimen Adequacy in Cervicovaginal CytologyBENIGN AND INFECTIOUS CONDITIONSNormal Pap TestInfectious and Other Organisms in Pap TestsNonneoplastic Findings, Mimics, and ArtifactsSQUAMOUS CELL ABNORMALITIES AND MIMICSLow-Grade Squamous Intraepithelial Lesion and MimicsHigh-Grade Squamous Intraepithelial Lesion and MimicsAtypical Squamous Cells of Undetermined SignificanceAtypical Squamous Cells, Cannot Rule Out High-Grade Squamous Intraepithelial LesionSquamous Cell Carcinoma of CervixGLANDULAR CELL ABNORMALITIESEndocervical Adenocarcinoma In Situ, Variants and MimicsEndocervical HPV-Dependent Invasive AdenocarcinomaEndocervical HPV-Independent Gastric Type AdenocarcinomaEndometrial Cancers in Pap TestsAtypical Glandular Cells: Endocervicals, Endometrials, and Glandulars, NOSEndometrial Cells in Pap Test and Glandular Cells Status Post HysterectomyEXTRAUTERINE CARCINOMAS AND OTHER MALIGNANCIES OF FEMALE GENITAL TRACTExtrauterine Cancers in Pap TestsNeuroendocrine Carcinoma of CervixOther Uncommon Malignancies in Pap TestsMOLECULAR TESTING IN GYNECOLOGIC CYTOLOGYHPV and Other Molecular Testing in Gynecologic CytologyDIRECTLY SAMPLED ENDOMETRIAL CYTOLOGYDirectly Sampled Endometrial CytologyANAL CYTOLOGYAnal CytologySECTION 2: EXFOLIATIVE CYTOPATHOLOGYGASTROINTESTINAL TRACTSpecimen Types in Respiratory Cytology and Adequacy CriteriaParasitic InfectionsViral InfectionsEsophagitis and Barrett EsophagusEsophageal AdenocarcinomaEsophageal Squamous Cell CarcinomaGastritis and Intestinal MetaplasiaGastric AdenocarcinomaGastric LymphomaGlomus TumorAmpulla/Bile Duct/Pancreatic Duct Reactive ChangesAmpulla/Bile Duct/Pancreatic Duct AdenocarcinomaColorectal Adenoma/CarcinomaNeuroendocrine Tumor/CarcinomaSpindle Cell Neoplasms of Gastrointestinal Tract, Including Gastrointestinal Stromal TumorsCEREBROSPINAL FLUIDNormal Cerebrospinal Fluid and Contamination by Normal ElementsInfectious MeningitisAseptic and Mollaret MeningitisSubarachnoid HemorrhageNeurodegenerative DiseasesPrimary Brain TumorsLeukemia and LymphomaMetastasis in Cerebrospinal FluidPLEURAL, PERITONEAL, PERICARDIAL, AND PELVIC FLUID AND WASHINGSNormal Cellular Components, Reactive Mesothelial Proliferations, and Reporting TerminologyInfectious ConditionsAutoimmune DiseasesMesothelioma in Effusions and Fine Needle CytologyMalignant Effusion, CarcinomasMetastatic Sarcomas in Effusions and WashingsLymphoid Effusions and Secondary Involvement by Hematopoietic NeoplasmsPrimary Effusion LymphomaEndometriosis and EndosalpingiosisOvarian NeoplasmsImmunocytochemistry, Histochemistry, and Other Ancillary TechniquesURINARY CYTOLOGYNormal Urinary Cytology, Specimen Types, and Reporting TerminologyIleal Conduit SpecimensNoninfectious Benign ConditionsInfectious Benign ConditionsReactive Urothelial ChangesLow-Grade Urothelial LesionsAtypical Urothelial CellsHigh-Grade Urothelial CancerSquamous Cell Carcinoma of Urinary BladderAdenocarcinoma of Urinary BladderOther Malignancies in Urinary CytologyRenal Pelvic CytologyAncillary Testing, UroVysion, and OthersSECTION 3: FINE-NEEDLE ASPIRATION, SUPERFICIALOVERVIEWSuperficial Aspiration TechniqueTHYROID GLANDUltrasound-Guided Thyroid Fine-Needle AspirationThyroid Fine-Needle Aspiration Reporting Terminology and Specimen AdequacyThyroid Follicular Nodular DiseaseChronic Lymphocytic/Hashimoto ThyroiditisGranulomatous ThyroiditisGraves Disease/Diffuse Toxic GoiterPigmented Thyroid Lesions and CrystalsAtypia of Undetermined Significance/Follicular Lesion of Undetermined SignificanceFollicular Neoplasm/Suspicious for a Follicular NeoplasmOncocytic Follicular Neoplasm in Thyroid Fine-Needle AspirationPapillary Thyroid Carcinoma, Classic SubtypePapillary Thyroid Carcinoma SubtypesMedullary Thyroid CarcinomaPoorly Differentiated Thyroid CarcinomaAnaplastic Thyroid CarcinomaThyroid LymphomaMetastatic Carcinoma to ThyroidOther Thyroid and Perithyroidal Lesions Encountered in Fine-Needle AspirationPARATHYROID GLANDParathyroid Cyst, Adenoma, and CarcinomaLYMPH NODESOverviewLymph Node Aspiration: Indications, Techniques, and ReportingFNA Sample Prep and Triage in Evaluating Suspected LymphomaBenign, Infectious, and Reactive HyperplasiaInflammatory and Reactive Lymphoid HyperplasiaGranulomatous Lymphadenitis, Infectious and SarcoidRosai-Dorfman DiseaseMetastatic MalignanciesHPV-Mediated Carcinomas in Neck Lymph NodesMetastatic MelanomaOther Metastatic Malignancies Encountered inLymph Node Fine-Needle AspirationNodal B-Cell LymphomaSmall Lymphocytic LymphomaLymphoplasmacytic LymphomaMantle Cell LymphomaNodal Marginal Zone LymphomaFollicular LymphomaBurkitt LymphomaLarge B-Cell LymphomaExtranodal B-Cell LymphomaPlasmacytomaMediastinal Large B-Cell LymphomaPlasmablastic LymphomaT-Cell LymphomaPeripheral T-Cell LymphomaMycosis FungoidesAngioimmunoblastic LymphomaALK(+) Anaplastic Large Cell LymphomaT-Cell Lymphoblastic LymphomaHodgkin LymphomaNodular Lymphocyte-Predominant Hodgkin LymphomaClassic Hodgkin LymphomaEYEApproach to Ophthalmic CytologyInfections in Ophthalmic CytopathologyNeoplasms in Ophthalmic CytopathologySALIVARY GLANDOverviewApproach to Interpretation of Salivary GlandAspiration Biopsies and Reporting Terminology (Milan System)Benign LesionsNormal Salivary Gland and Sialadenitis on AspirationCystsPleomorphic AdenomaWarthin TumorMyoepitheliomaSalivary Gland OncocytomaMalignant NeoplasmsAdenoid Cystic CarcinomaAcinic Cell CarcinomaMucoepidermoid CarcinomaBasaloid Neoplasms, Benign and MalignantCarcinoma Ex Pleomorphic AdenomaAdenocarcinoma, NOSPolymorphous AdenocarcinomaSalivary Duct CarcinomaSalivary Gland Secretory CarcinomaMyoepithelial CarcinomaCribriform AdenocarcinomaMetastatic CarcinomaPrimary and Metastatic Nonepithelial TumorsBREASTOverviewRole of Fine-Needle Aspiration of Breast, Techniques and Triple TestBenign Breast LesionsInflammatory and Granulomatous ConditionsFat NecrosisNonproliferative and Proliferative Changes in BreastRadial Scar/Complex Sclerosing LesionGynecomastiaMucocele-Like LesionBenign NeoplasmsFibroadenomaGranular Cell Tumor of BreastPapillary NeoplasmsMyofibroblastoma, MammaryMalignant NeoplasmsDuctal Carcinoma and Variants of Invasive Mammary CarcinomaLobular CarcinomaPhyllodes TumorAngiosarcoma and Other SarcomasLymphomas and Metastatic TumorsNipple DischargeCytology Specimens for Risk Assessment of Breast CancerSKIN AND SUBCUTANEOUS CYTOLOGYCutaneous and Adnexal CytologyFat Pad Aspiration for AmyloidSECTION 4: FINE-NEEDLE ASPIRATION, DEEP ORGANS AND TISSUES OVERVIEWTechniques and Modalities of Deep Aspiration BiopsiesTechniques and Modalities of Bronchoscopic Aspiration and Small BiopsiesTechniques and Modalities of Gastrointestinal Endoscopic Aspiration and Small BiopsiesRESPIRATORY TRACT, INCLUDING LUNG FNASSpecimen Types in Respiratory Cytology and Adequacy CriteriaBenign and Reactive ChangesFungal Yeasts and Hyphal OrganismsPneumocystis PneumoniaParasitic OrganismsViral Infections (Cytomegalovirus, Herpesvirus, and Others)Mycobacteria and Other Bacterial InfectionsSarcoidosis and Other Immune-Related ConditionsPulmonary Alveolar Proteinosis and MimicsMiscellaneous Findings, Including ContaminantsAdenocarcinoma of LungSquamous Cell Carcinoma of LungSmall Cell Carcinoma of LungLarge Cell Neuroendocrine Carcinoma of LungCarcinoid and Atypical Carcinoid of LungRare Benign and Low Malignant Potential TumorsRare Malignant TumorsNUT CarcinomaSMARCA4-Deficient Undifferentiated TumorPulmonary LymphomaPulmonary MetastasisMEDIASTINUMOverviewAnatomic Compartments and Constituent TumorsNonneoplastic LesionsMediastinal Cysts and Inflammatory LesionsNeoplasmsThymomaThymic CarcinomaGerm Cell TumorsMediastinal Neurogenic TumorsMetastatic Tumors of MediastinumLIVEROverviewCytology of Normal LiverInflammatory and Infectious Conditions of LiverBenign Hepatic NeoplasmsHepatocellular AdenomaFocal Nodular HyperplasiaHemangioma and Other Vascular Tumors of LiverMalignant NeoplasmsHepatocellular CarcinomaHepatoblastomaLiver MetastasisKIDNEYOverviewCytology of Normal KidneyIndolent Neoplasms and Benign LesionsRenal CystsAngiomyolipomaRenal Oncocytoma and Other Indolent Oncocytic TumorsMetanephric AdenomaMetanephric Stromal TumorXanthogranulomatous Pyelonephritis/MalakoplakiaMalignant NeoplasmsClear Cell Renal Cell CarcinomaPapillary Renal Cell CarcinomaClear Cell Papillary Renal Cell TumorChromophobe Renal Cell CarcinomaTFE3- and TFEB-Rearranged Renal Cell CarcinomasCollecting Duct CarcinomaRenal Medullary CarcinomaMucinous Tubular and Spindle Cell Carcinoma of KidneyRenal Neuroendocrine TumorPrimary Renal Sarcomas in AdultsRenal LymphomasNephroblastoma (Wilms Tumor)Clear Cell Sarcoma of KidneyCongenital Mesoblastic NephromaRhabdoid Tumor of KidneyMetastatic Tumors to KidneyOther Rare and Recently Described Malignant Kidney TumorsTumors Of Renal PelvisUrothelial CarcinomaADRENAL GLANDOverviewCytology of Normal Adrenal GlandAdrenal Cortical LesionsAdrenal Cortical AdenomaAdrenal Cortical CarcinomaMetastatic Tumors to Adrenal GlandADRENAL MEDULLARY LESIONSPheochromocytomaPANCREASOverviewCytology of Normal PancreasPancreaticobiliary Cytology Reporting Terminology, Cyst EvaluationNonneoplastic LesionsPancreatitisLymphoepithelial Cyst of PancreasIntra- and Peripancreatic SplenulesNeoplasmsSerous Microcystic AdenomaMucinous Cystic NeoplasmIntraductal Papillary Mucinous NeoplasmSolid Pseudopapillary NeoplasmPancreatic Neuroendocrine TumorPancreatic Ductal AdenocarcinomaUnusual Variants of Ductal CarcinomaAcinar Cell CarcinomaLymphoma and Secondary Tumors of PancreasBONEOverviewApproach to Cytologic/Small Biopsy Diagnosis ofPrimary Bone TumorsNeoplasmsChondromas of Bone and Soft TissueChondroblastomaGiant Cell TumorOsteoblastomaAdamantinomaLangerhans Cell HistiocytosisChordomaOsteosarcomaChondrosarcomaEwing SarcomaBone LymphomaMetastatic Tumors of BoneSOFT TISSUEOverviewApproach to Cytologic/Small Biopsy Diagnosis of Primary Soft Tissue LesionsAdipocytic TumorsBenign Adipose Tissue TumorsLiposarcomaFibroblastic/Myofibroblastic LesionsFibrosarcomaMyofibroblastomaLow-Grade Myofibroblastic SarcomaLow-Grade Fibromyxoid SarcomaMyxofibrosarcomaTumors of Muscle OriginSmooth Muscle TumorsSkeletal Muscle TumorsVascular and Pericytic TumorsHemangioma, Soft TissueEpithelioid HemangioendotheliomaKaposi SarcomaAngiosarcomaOther TumorsUndifferentiated Pleomorphic SarcomaGiant Cell Tumor of Tendon SheathOther Reactive and Neoplastic Soft Tissue EntitiesMesenchymal ChondrosarcomaSolitary Fibrous TumorIntramuscular MyxomaSynovial SarcomaEpithelioid SarcomaAlveolar Soft Part SarcomaClear Cell Sarcoma of Soft TissueDesmoplastic Small Round Cell TumorNEUROPATHOLOGYNeuropathology Squash Preparations, InfectiousNeuropathology Squash Preparations, Glial NeoplasmsNeuropathology Squash Preparations, Nonglial NeoplasmsSECTION 5: MANAGEMENT AND ANCILLARY TESTINGCYTOPREPARATORY AND QUALITY MANAGEMENTCytopreparatory Techniques and Instrumentation inNongynecologic CytologyQuality Improvement and Laboratory Management for CytopathologyANCILLARY TESTINGImmunocytochemistryMolecular Techniques