Multifunctional Nano pharmaceuticals for Biomedical Applications

Dr. Sushil K. Kashaw is an Associate Professor in the Department of Pharmaceutical Sciences and his Integrated Drug Discovery Research Laboratory is focused to develop new molecules for the treatment of cancer, tuberculosis, malaria and other life threatening diseases. He has completed his Raman Postdoctoral Research from Wayne State University, Detroit, USA in 2016. To his credit he has 110 high impact research publications, six books, six book chapters, one granted and two filed patent. Dr. Kashaw has completed five research projects sponsored by SERB, UGC, MPCST. His total citations are 3919, h-index 28 and i10 of 49. He has been conferred with many prestigious awards/fellowships like Raman Postdoctoral Fellowship, Outstanding Oral Presentat ion Award from APP, Young Scientist Award by APP, Best Teacher Award in Pharm. Chemistry by APTI, M.P. branch, Research Excellence Award by Institute of Scholars, Best Researcher and Pharma recognition award by Nirali Publication in association with APTI and thirty five awards as co-author at various scientific platforms. He has delivered 42 invited lectures, chaired 28 scientific sessions, presented 40 papers in the conferences and developed 10 e-contents for CEC-MHRD. Apart from his academic credentials Dr. Kashaw is actively contributing in the holistic development of the university. Currently he is the Member of the Executive Council and former Member of Academic Council of the university. He has organized several conferences and training programmes for students and teachers. Dr. Kashaw has supervised five PhD and forty nine M. Pharm students. His area of research is molecular modeling, medicinal chemistry and nanotechnology. Dr. Iyer is the Director of Use-inspired Biomaterials and Integrated Nano Delivery (U-BiND) Systems Laboratory and an Associate Professor with Tenure in the Department of Pharmaceutical Sciences at Wayne State University in Detroit, Michigan, USA. He also serves as a Scientific Member of the Molecular Imaging Program (MIP) at the Barbara Ann Karmanos Cancer Institute in Detroit, Michigan, USA. Dr. Iyer received his PhD in 2008, in Polymer Engineering, under the mentorship of world-renowned scientist and 2016 Nobel Prize in Chemistry Nominee, Prof. Hiroshi Maeda at Sojo University in Kumamoto, Japan. Dr. Iyer was the recipient of the Controlled Release Society’s (CRS) T. Nagai Research Achievement Award in 2012. Dr. Iyer completed his postdoctoral training in Cancer Radiology at the University of California, San Francisco (UCSF) in California, USA. In 2018 Dr. Iyer received an Early Career Investigator Award from the US Department of Defense (DoD). Dr. Iyer has authored more than 100 publications in peer reviewed International Journals (H-index:45), and books of high repute. He has more than 200 scientific presentations and invited talks at International Conferences and Workshops. He has five patents issued/pending. His areas of research are broadly focused on designing use-inspired bio- and nano-medical technologies aimed towards clinical translation using biocompatible delivery systems that have enhanced disease targeting with reduced toxicity burden to patients. He has wide expertise in biomaterials and nanomedicine, polymer chemistry and formulation development, drug and gene delivery systems, molecular and functional imaging, micro and nanoparticles for treating diseases such as infection,cancerand age-related dementia. His laboratory is funded by agencies such as National Institutes of Health and the US Department of Defense. Dr Rakesh K Tekade, Assistant Professor of the Department of Pharmaceutics, investigates the design, development and characterization of targeted nanotechnology based formulations for the site specific delivery of therapeutic drugs, siRNA, microRNA, plasmids, proteins and peptide for the treatment of cancer. His current research encompasses development of novel polymeric nanomaterial for effective cytosolic delivery of anticancer bioactives. Dr Tekade’s research is focused on designing a new generation of nanoparticles, which could identify the cancer cells and selectively deliver anticancer drugs and genes to inhibit the growth of cancer while sparing healthy tissues. His research work involves the applications of polymer chemistry, nanotechnology, molecular biology, pharmacokinetics/pharmacodynamics and imaging techniques. Dr Tekade has over 70 publications, 01 patent, 7 book chapters, and 3 editorial articles. He has delivered several invited research talks and presented research finding in more than 30 scientific conferences. Ms. Sakshi, an accomplished M. Pharma graduate and a current Ph.D. scholar at Dr. Harisingh Gour Vishwavidyalaya, Sagar, Madhya Pradesh. Her academic journey has honed her skills in drug development and nanotechnology. With a focus on nano pharmaceuticals for Various Cancer and neurological disorders, she enriches the book's content with emerging insights and contemporary research.

• Part I: Foundations and Platforms1. Nanotechnology and Drug Delivery: Fundamentals and Applications2. Nanocarriers for Nucleic Acid Delivery3. Nanomaterials for Imaging and Diagnostics4. Multitargeted Polymeric Nanoparticles for Drug Delivery5. Supramolecular Dendrimers-Based Nanoplatform for Drug Delivery: Synthetic Strategy6. Bioresponsive Nanogel-Based Drug Delivery: Concept, Methods and Biological Applications7. Bifunctional Nanoemulsions: Concepts, Formulation and Their Biological ApplicationsPart II: Advanced Platforms and Emerging Technologies8. Multifunctional Carbon-Based Nanomaterials for Drug Delivery: Concept and Mechanism9. Biomimetic Nanomicelles for Drug Delivery: Concept, Methods and Their Biomedical applications10. Nanorobots as Intelligent Drug Delivery: Concepts, Applications, and ChallengesPart III: Clinical Considerations and Future Perspectives11. Translating Nanopharmaceuticals to the Clinic12. Generic Nanopharmaceuticals: Challenges and Opportunities13. Nanofibers and Nanotubes for Biomedical Applications14. PEGylated Synthetic Surfactant Vesicles (Niosomes):Overcoming the Challenges of Drug Delivery15. The Future of Smart Nano Sponges in Controlled Drug Delivery16. Applications of Virus-Like Particles (VLPs) in therapeutics17. Regulatory and Safety Aspects of Nanomedicine: Current Perspective in Managing Nanotoxicity