Dr. Dibyajit Lahiri is an Associate Professor in the Department of Biotechnology at the University of Engineering & Management, Kolkata, India, where he conducts advanced interdisciplinary research in microbiology, biofilms, antimicrobial resistance, and microbial biotechnology. His scholarly work emphasizes understanding the mechanisms of microbial biofilm formation and inhibition, particularly on medically relevant surfaces and environmental substrates, and exploring innovative strategies for combating biofilm-associated antimicrobial resistance. Dr. Lahiri has authored and co-authored a substantial body of scholarly work, with over 100 publications including high-impact journal articles, book chapters, and reviews. His research portfolio covers topics such as biofilm-mediated degradation of environmental pollutants, novel antibiofilm agents (including nanoscale and natural compounds), and biotechnological applications of microbial systems, with an h-index around 38 reflecting significant citation impact and academic influence.He has contributed to major scientific discussions on microbial biofilms in diverse contexts, including their roles in chronic infections, environmental microplastic degradation, and biofuel production, demonstrating both fundamental and applied research orientations. His collaborative research outputs also include contributions to antimicrobial peptide studies and microbial electrochemical systems. Dr. Lahiri serves as editor and contributor to scholarly publications in his field, and he participates actively in international research networks and editorial activities. His work is regularly presented at scientific forums and continually contributes to advancing microbial biotechnology and strategies to mitigate biofilm-associated challenges in health, industry, and the environment. Moupriya Nag is presently working as Associate Professor in the Department of Biotechnology, University of Engineering & Management, Kolkata. Her research interests includes single molecule Biophysics of protein unfolding/refolding and protein aggregation kinetics and its mechanism of action especially the amyloid proteins in neurodegenerative disorders. Recently, her research focuses on functional amyloids in bacteria and their relation in forming biofilms. Her work deals with developing novel antimicrobial and anti-biofilm compounds from natural sources including plants, microbes and green synthesized nanoparticles. She has about seven years of teaching experience in Biophysics, Bioinformatics, Bioprocess and Biotechnology, Enzyme Technology, Computing, Molecular Modelling and Drug Design. She has also published many research articles in the peer-reviewed international journals and authored/edited or co-authored/edited numerous books/book chapters. She is also a member of many scientific societies like Indian Biophysical Society and Indian Science Congress Association.Dr. Gargi Bhattacharya is a Microbiologist with over nine years of post-MD professional experience in clinical microbiology, serology, molecular biology, and infection control. She completed her MBBS from North Bengal Medical College and MD in Microbiology from the Calcutta School of Tropical Medicine, where she was a Gold Medalist, followed by DNB in Microbiology. She is currently associated with Ruby General Hospital and has previously worked with Ashok Laboratory and Nursing Home and Medinova Diagnostic Services. Her expertise includes NABL-accredited laboratory quality systems and infection control, with specialized training from JIPMER, Puducherry. Her research interests include antimicrobial resistance, bacterial persistence, biofilm-associated infections, and antimicrobial stewardship. She has published research and case reports on multidrug resistance, Staphylococcus aureus, Staphylococcus cohnii, anthrax, and urinary tract infections. She is a member of IAMM and the Antimicrobial Stewardship Society, India.Leonard Ionuț Atanase, PhD, is Full Professor at the Faculty of Medicine, Apollonia University of Iași, Romania, and Member of the Academy of Romanian Scientists. His research focuses on polymer chemistry, biomaterials, and nanomedicine, with particular emphasis on polymeric drug delivery systems, electrospun nanofibers, hydrogels, and stimuli-responsive biomaterials for biomedical applications. He coordinates national and international research projects, including Horizon Europe, M-ERA.NET, and Erasmus+ initiatives, and supervises doctoral and postgraduate research. His current work is dedicated to developing advanced polymer-based nanocarriers for targeted drug delivery, cancer therapy, and regenerative medicine.

• Section 1: Fundamentals of Biofilms and Immunity1. Introduction to Biofilms: Definition, Formation, and Characteristics2. Biofilms in Nature and Medicine: From Environmental to Clinical Settings3. Host-Pathogen Interactions: Immune Evasion by Biofilms4. The Role of Innate Immunity in Biofilm Recognition and Response5. Adaptive Immune Responses to Biofilm-Associated Infections6. Inflammation and Chronicity: How Biofilms Drive Persistent Infections7. Microbiome and Biofilms: Friend or Foe?8. Quorum Sensing and Biofilm Development: Implications for Disease9. Genetic and Epigenetic Regulation of Biofilm-Associated Pathogens10. Biofilms in the Context of Antimicrobial Resistance (AMR)Section 2: Biofilms in Chronic Diseases11. Biofilms and Periodontal Disease: Mechanisms and Clinical Impact12. Chronic Wound Infections: Biofilm Formation and Healing Impairment13. Respiratory Infections: The Role of Biofilms in Cystic Fibrosis and COPD14. Biofilms in Otitis Media: Chronic Ear Infections and Treatment Challenges15. Urinary Tract Infections: Biofilm-Mediated Persistence and Recurrent Infections16. Gastrointestinal Biofilms: Role in Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD)17. Biofilms in Endocarditis: A Persistent Cardiac Threat18. Implant-Associated Biofilm Infections: Orthopedic and Dental Perspectives19. Biofilms in Chronic Sinusitis: Implications for Therapeutic Strategies20. Catheter-related blood stream infections21. Sexually Transmitted Infections and Biofilms: A Hidden Factor in ChronicitySection 3: Immunological Perspectives and Biofilms in Cancer Development22. Biofilms and Cancer: A New Frontier in Tumor Biology23. The Role of Bacterial Biofilms in Gastrointestinal Cancers24. Oral Biofilms and Head & Neck Cancers: Immunological Implications25. Urinary and Reproductive Biofilms in the Development of Bladder and Cervical Cancer26. Microbial Dysbiosis, Biofilms, and Colorectal Carcinogenesis27. Immunosuppressive Mechanisms of Biofilms in Cancer Progression28. Biofilms, Immune Evasion, and Chemoresistance in Cancer Therapy29. Potential Immunotherapies Targeting Biofilm-Mediated Tumor GrowthSection 4: Immunological Response of Biofilms in Neural Disorders30. Neuroinflammation and Biofilms: Bridging the Gap31. The Gut-Brain Axis: Role of Biofilms in Neurological Disorders32. Biofilm-Associated Infections in Alzheimer’s Disease: A Hidden Contributor?33. Parkinson’s Disease and the Influence of Chronic Biofilm Infections34. Multiple Sclerosis and Bacterial Biofilms: A New Perspective on Autoimmunity35. Neuropsychiatric Disorders and Biofilm-Driven Dysregulation of Immunity36. Meningitis, Encephalitis, and Biofilm-Associated Pathogens in the CNS37. Biofilms, Blood-Brain Barrier Integrity, and Neuroimmune Dysfunction38. Chronic Lyme Disease and Biofilm-Mediated Neurological Complications39. Targeting Biofilms in Neurological Disorders: Immunotherapy and Emerging StrategiesSection 5: Therapeutic Challenges and Emerging Strategies40. Vaccine Development Against Biofilm-Forming Pathogens41. The Role of Probiotics and Prebiotics in Modulating Biofilm Formation42. Nanotechnology and Biofilm Disruption: Advances in Antimicrobial Strategies43. Phage Therapy and Enzymatic Degradation of Biofilms44. Immunomodulatory Therapies: Enhancing Host Defense Against Biofilms45. Biomaterials and Coatings to Prevent Biofilm Formation in Medical Devices46. Combination Therapy: Antibiotics, Immunotherapy, and Novel Antibiofilm Agents47. Emerging Anti-Biofilm Strategies: Future Research Directions48. Conclusion: Translating Research into Clinical and Therapeutic StrategiesSection 6: AI and Machine Learning in Understanding Biofilm-Associated Immune Responses49. The Role of AI in Immunological Research: Transforming Biofilm Studies50. Machine Learning Models for Predicting Biofilm Formation and Immune Interactions51. AI-Driven Analysis of Host-Pathogen Interactions in Biofilm Infections52. Big Data and Computational Immunology: Unlocking Biofilm-Immune Dynamics53. Neural Networks for Identifying Biofilm-Associated Biomarkers in Chronic Disease54. AI-Guided Drug Discovery and Immunotherapy Targeting Biofilms55. Personalized Medicine: AI-Driven Approaches to Treating Biofilm-Related Diseases