Solvent Interaction Analysis

Physical Chemistry and Analytical Applications of Aqueous Two-Phase Systems

AvBoris Y. Zaslavsky,Vladimir N. Uversky

Häftad, Engelska, 2027

1 826 kr

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Beskrivning

Solvent Interaction Analysis: Physical Chemistry and Analytical Applications of Aqueous Two-Phase Systems explores Solvent Interaction Analysis (SIA) technology, a cutting-edge approach for protein characterization and proteomics in biological fluids. The book considers a broad spectrum of topics, from fundamental principles such as phase separation, blood-tissue distribution, and posttranslational protein modifications, to advanced clinical applications for early detection of various malignancies, neurological disorders, and other diseases. The book opens with an introduction to aqueous two-phase system (ATPS), considering different types of ATPS, hydrophobic and electrostatic properties, and mechanisms of liquid-liquid phase separation, before moving on to specific properties of phases such as solute-water interaction and blood-tissue distribution, and analysis of partitioning individual proteins. It then explores solvent interaction analysis, investigating diagnostic applications and biomarker discovery. Final chapters explore fundamental consequences of ATPS-based analysis and its future opportunities. This comprehensive guide offers a detailed overview of aqueous two-phase systems from foundational knowledge to the latest developments in the field, and is an essential reference for students, researchers and practitioners across a wide range of disciplines, including biophysics, analytical and medicinal chemistry, proteomics, structural biology, pharmaceutical science, and biotechnology.

Produktinformation

Utgivningsdatum:2027-05-01
Mått:191 x 235 x undefined mm
Vikt:450 g
Format:Häftad
Språk:Engelska
Förlag:Elsevier Science Publishing Co Inc
ISBN:9780443456794

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Mer om författaren

Dr. Boris Y. Zaslavsky graduated from Moscow State University as a bioanalytical chemist in 1967. He worked at the USSR Academy of Sciences, received a Ph.D. degree in 1974, and Dr.Sci. degree in 1986. He left the USSR for the USA in 1991 to take up a visiting scholar position at Cornell Medical College in New York City. He worked at KV Pharmaceuticals and Argonne National Laboratory. In 1996 Dr. Zaslavsky cofounded Analiza, Inc. and Cleveland Diagnostics, Inc. in 2013. He pioneered analytical applications of extractions in aqueous two-phase systems and the development of Solvent Interaction Analysis for quality control of biopharmaceuticals, and clinical testing for early detection of various malignancies. He has authored more than 170 research papers and reviews and one book, “Aqueous Two-Phase Partitioning: Physical Chemistry and Bioanalytical Applications.Prof. Vladimir N. Uversky, PhD, DSc, FRSB, FRSC, F.A.I.M.B.E., Professor at the Department of Molecular Medicine, Morsani College of Medicine, University of South Florida (USF), is a pioneer in the field of protein intrinsic disorder. He has made a number of groundbreaking contributions in the field of protein folding, misfolding, and intrinsic disorder. He obtained his PhD from Moscow Institute of Physics and Technology and D.Sc. from the Institute of Experimental and Theoretical Biophysics, Russian Academy of Sciences. Since 2010, Professor Uversky has worked at University of South Florida, where he works on various aspects of protein intrinsic disorder phenomenon and analysis of protein folding and misfolding processes. He has authored over 1250 scientific publications and edited several books and book series on protein structure, function, folding, misfolding, and intrinsic disorder. He also servs as an editor in a number of scientific journals.

Innehållsförteckning

1. Aqueous two-phase systems2. Properties of phases3. Analysis of partitioning of individual proteins4. Solvent interaction analysis5. Fundamental consequences of the ATPS-based analysis6. Biological liquid-liquid phase separation, membrane-less organelles, and biomolecular condensate