Vladimir N Uversky - Böcker
1 690 kr
Skickas inom 7-10 vardagar
Bio-Nanoimaging: Protein Misfolding & Aggregation provides a unique introduction to both novel and established nanoimaging techniques for visualization and characterization of misfolded and aggregated protein species. The book is divided into three sections covering:- Nanotechnology and nanoimaging technology, including cryoelectron microscopy of beta(2)-microglobulin, studying amyloidogensis by FRET; and scanning tunneling microscopy of protein deposits - Polymorphisms of protein misfolded and aggregated species, including fibrillar polymorphism, amyloid-like protofibrils, and insulin oligomers- Polymorphisms of misfolding and aggregation processes, including multiple pathways of lysozyme aggregation, misfolded intermediate of a PDZ domain, and micelle formation by human islet amyloid polypeptide
Protein misfolding and aggregation is a fast-growing frontier in molecular medicine and protein chemistry. Related disorders include cataracts, arthritis, cystic fibrosis, late-onset diabetes mellitus, and numerous neurodegenerative diseases like Alzheimer's and Parkinson's. Nanoimaging technology has proved crucial in understanding protein-misfolding pathologies and in potential drug design aimed at the inhibition or reversal of protein aggregation. Using these technologies, researchers can monitor the aggregation process, visualize protein aggregates and analyze their properties.
Provides practical examples of nanoimaging research from leading molecular biology, cell biology, protein chemistry, biotechnology, genetics, and pharmaceutical labs Includes over 200 color images to illustrate the power of various nanoimaging technologies Focuses on nanoimaging techniques applied to protein misfolding and aggregation in molecular medicineDancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B
1 943 kr
Skickas inom 7-10 vardagar
Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.
Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided Includes contributions from recognized experts in the fieldDroplets of Life
Membrane-Less Organelles, Biomolecular Condensates, and Biological Liquid-Liquid Phase Separation
1 898 kr
Skickas inom 7-10 vardagar
Droplets of Life: Membrane-Less Organelles, Biomolecular Condensates, and Biological Liquid-Liquid Phase Separation provides foundational information on the biophysics, biogenesis, structure, functions, and roles of membrane-less organelles. The study of liquid-liquid phase separation has attracted a lot of attention from disciplines such as cell biology, biophysics, biochemistry, and others trying to understand how, why, and what roles these condensates play in homeostasis and disease states in living organisms. This book's editor recruited a group of international experts to provide a current and authoritative overview of all aspects associated with this exciting area.Sections introduce membrane-less organelles (MLOs) and biomolecular condensates; MLOs in different sizes, shapes, and composition; and the formation of MLOs due to phase separation and how it can tune reactions, organize the intracellular environment, and provide a role in cellular fitness.
. Presents the first book to establish the foundations of this exciting research area Combines biophysics, structural and cell biology, and biochemistry perspectives into a single volume Edited and authored by world-leading scientists Covers basic physical and biological principles and health and disease implicationsDancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C
2 083 kr
Skickas inom 7-10 vardagar
Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C, Volume 183 represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this volume include discussions on the evolution of disorder, consideration of the peculiarities of phase separation of the prion protein, a general discussion of the relationships between intrinsic disorder and protein functions, coverage of the structural and functional characterization of several important intrinsically disordered proteins, such as transcription factors, outer membrane porins, trans-membrane and membrane associated proteins with ID regions, discussion of molecular simulations of IDPs, and much more.
Provides recent studies on the intrinsically disordered proteins and their functions, along with the involvement of intrinsically disordered proteins in the pathogenesis of various diseases Contains numerous illustrative materials (color figures, diagrams and tables) to help readers delve into the information provided Includes contributions from recognized experts in the field1 739 kr
Skickas inom 7-10 vardagar
Structure and Intrinsic Disorder in Enzymology offers a direct, yet comprehensive presentation of the fundamental concepts, characteristics and functions of intrinsically disordered enzymes, along with valuable notes and technical insights powering new research in this emerging field. Here, more than twenty international experts examine protein flexibility and cryo-enzymology, hierarchies of intrinsic disorder, methods for measurement of disorder in proteins, bioinformatics tools for predictions of structure, disorder and function, protein promiscuity, protein moonlighting, globular enzymes, intrinsic disorder and allosteric regulation, protein crowding, intrinsic disorder in post-translational, and much more.
Chapters also review methods for study, as well as evolving technology to support new research across academic, industrial and pharmaceutical labs.
Unifies the roles of intrinsic disorder and structure in the functioning of enzymes and proteins Examines a range of enzyme and protein characteristics, their relationship to intrinsic disorder, and methods for study Features chapter contributions from international leaders in the fieldProtein Misfolding, Aggregation and Conformational Diseases
Part A: Protein Aggregation and Conformational Diseases
2 100 kr
Skickas inom 10-15 vardagar
Protein Misfolding, Aggregation and Conformational Diseases
Part B: Molecular Mechanisms of Conformational Diseases
2 100 kr
Skickas inom 10-15 vardagar
The Three Functional States of Proteins
Structured, Intrinsically Disordered, and Phase Separated
1 727 kr
Skickas inom 7-10 vardagar
The Three Functional States of Proteins explores how structured proteins, intrinsically disordered proteins, and phase separated proteins contribute to the complexity of cellular life, and offers insights into their roles in both health and disease. It discusses the latest research findings and highlight groundbreaking discoveries and innovative methodologies used to study these protein states.Traditionally, the different states of proteins have been defined based on their structures and functions. However, it is becoming increasingly clear that these criteria alone may not be sufficient to capture the complex and multifaceted properties of these molecules. Definitions based on thermodynamics and kinetics are now recognized as potentially more appropriate for comprehensively understanding protein states. Emerging evidence indicates that under physiological conditions, a majority of proteins possess the capability to exist in and transition between the native, droplet, and amyloid states. These distinct states play crucial roles in various cellular functions, influenced significantly by their physicochemical and structural properties. The book also considers the interactions among these states and discusses how their internal organization as individual molecules, as well as their collective organization as molecular assemblies are stabilized. Furthermore, it examines the processes by which these states are formed and the cellular functions associated with each specific state.
The book serves as an introduction to a unique volume that provides comprehensive coverage of these three functional states of proteinsThe chapters are written by leading global scientists who are actively engaged in research on these specific protein statesIt presents a broad picture of the current, emerging, and evolving research on these protein statesGiven that this book comprehensively addresses both foundational concepts and recent advancements in the field, it will appeal a broad spectrum of readers from various academic disciplines1 686 kr
Skickas inom 10-15 vardagar
Protein Misfolding, Aggregation and Conformational Diseases
Part A: Protein Aggregation and Conformational Diseases
2 163 kr
Skickas inom 10-15 vardagar
Protein Misfolding, Aggregation and Conformational Diseases
Part B: Molecular Mechanisms of Conformational Diseases
2 163 kr
Skickas inom 10-15 vardagar
6 120 kr
Skickas inom 10-15 vardagar
Intrinsically Disordered Protein Analysis
Volume 2, Methods and Experimental Tools
1 064 kr
Skickas inom 10-15 vardagar
Intrinsically Disordered Protein Analysis
Volume 2, Methods and Experimental Tools
1 525 kr
Skickas inom 10-15 vardagar
Intrinsically Disordered Protein Analysis
Volume 1, Methods and Experimental Tools
2 183 kr
Skickas inom 5-8 vardagar
Intrinsically Disordered Protein Analysis
Volume 1, Methods and Experimental Tools
2 100 kr
Skickas inom 10-15 vardagar
SARS-CoV-2 Variants and Global Population Vulnerability
Diagnostic Strategies, Vaccine Development, and Therapeutic Management
2 773 kr
Skickas inom 10-15 vardagar
2 496 kr
Skickas inom 10-15 vardagar
1 786 kr
Skickas inom 7-10 vardagar
551 kr
Skickas inom 10-15 vardagar