Vivek P. Chavda - Böcker

Advanced Vaccination Technologies for Infectious and Chronic Diseases is a comprehensive guide that delves into the intricate details of vaccine design, development across various platforms, and the path to commercialization. This book provides an introductory overview of vaccines, covering various types, developmental methodologies, delivery systems, adjuvants, immunization, and measurement of vaccine efficacy. It also showcases examples of vaccine research efforts targeting infectious diseases, autoimmune disorders, and cancer. The book concludes by exploring cutting-edge advances in proteogenomics, immunopeptidomics, and future vaccine technologies.The primary objective of this book is to inform a broad scientific audience about the fundamental concepts underlying vaccine and immunology. Further, it serves as an invaluable reference for understanding the critical steps in the journey from discovery to regulatory processes for human clinical trials, addressing common misconceptions and presenting factual information about vaccinations. Advanced Vaccination Technologies for Infectious and Chronic Diseases is a requisite reference for occupational health professionals whose roles involve supervision of immunization programs such as those working within the National Health Service, some sectors of higher education, or the pharmaceutical industry. It also caters to those researchers engaged in vaccine development and all who want to learn the processes involved from laboratory research to final product.

Offers comprehensive coverage of different vaccine platforms and their developmentIncludes information on the regulatory perspective of vaccine developmentDescribes different delivery approaches for vaccinologyExplains the clinical development of vaccines along with novel platformsCovers all recent developments of vaccine production technologies, new types of vaccines, and ongoing research that could prevent future pandemics

BIOINFORMATICS TOOLS FOR Pharmaceutical DRUG PRODUCT DLEVELOPMENT A timely book that details bioinformatics tools, artificial intelligence, machine learning, computational methods, protein interactions, peptide-based drug design, and omics technologies, for drug development in the pharmaceutical and medical sciences industries. The book contains 17 chapters categorized into 3 sections. The first section presents the latest information on bioinformatics tools, artificial intelligence, machine learning, computational methods, protein interactions, peptide-based drug design, and omics technologies. The following 2 sections include bioinformatics tools for the pharmaceutical sector and the healthcare sector. Bioinformatics brings a new era in research to accelerate drug target and vaccine design development, improving validation approaches as well as facilitating and identifying side effects and predicting drug resistance. As such, this will aid in more successful drug candidates from discovery to clinical trials to the market, and most importantly make it a more cost-effective process overall. Readers will find in this book: Applications of bioinformatics tools for pharmaceutical drug product development like process development, pre-clinical development, clinical development, commercialization of the product, etc.; The ever-expanding application of this novel technology and discusses some of the unique challenges associated with such an approach;The broad and deep background, as well as updates, on recent advances in both medicine and AI/ML that enable the application of these cutting-edge bioinformatics tools.Audience The book will be used by researchers and scientists in academia and industry including drug developers, computational biochemists, bioinformaticians, immunologists, pharmaceutical and medical sciences, as well as those in artificial intelligence and machine learning.

NANOCARRIER VACCINES This book details the benefits, restrictions, and types of nanoparticles used in the creation of vaccines for the treatment and prevention of illnesses. In nanomedicine and nano-delivery systems, materials in the nanoscale range are used as diagnostic instruments or to administer therapeutic compounds to particular targeted regions in a controlled manner. By delivering precise medications to specified locations and targets, nanotechnology provides several advantages in treating chronic human illnesses. The use of nanomedicine (including chemotherapeutic medicines, biological agents, immunotherapeutic agents, etc.) in the treatment of various diseases has recently seen many notable applications. This book aims to be a single source material for understanding all the current and novel advancements in the field of nanotechnology. In this groundbreaking book the reader will find: biodegradable and non-biodegradable formulations and properties such as size, shape, charge, inertness, efficacy, morphology, and more;show how different nanoparticles, such as lipid-based, viral vector-based, and metal, uphold very significant properties individually, suggesting applicability in various management tactics;examines how genetic information-carrying entities are becoming the norm for eradicating some diseases; gathers an exhaustive amount of information on routes of administration such as the oral route, mucosal immunity, intramuscular, subcutaneous, and intradermal; explores the legal regulations for nanotechnology-based approaches.Audience Researchers and pharmacy students in biomedical engineering and chemical engineering, biotechnology, as well as pharmaceutical and biopharmaceutical industry engineers working in drug discovery, chemical biology, computational chemistry, medicinal chemistry, and bioinformatics.

The book presents invaluable insights into the latest advancements, challenges, and research on vaccine adjuvants, which are key to developing more effective and safer vaccines essential for tackling pressing global health challenges. Emerging Pathways of Vaccine Adjuvants: A Nonspecific Stimulant of the Immune System aims to drive progress in vaccine research, paving the way for the development of more potent and safer vaccines to address global health threats. This volume provides a comprehensive overview of the evolving landscape of vaccine adjuvants, encompassing a wide range of topics critical to their design, development, and application. Adjuvants play a crucial role in vaccine formulations by boosting the immunogenicity of antigens, thereby enhancing vaccine efficacy. While antigens can initiate immune responses independently, adjuvants amplify these responses. Extensive research efforts are focused on the formulation of adjuvants to establish accurate, efficient, and safe manufacturing techniques. This book provides a clear explanation of the strict regulatory issues, making it an essential resource for students, businesspeople, and academics across the globe. Readers will find the book: Encompasses current adjuvant usage and possible tactics to ensure effective production and delivery of the active constituent;Presents challenges and innovations with implications to provide cheaper, more efficient solutions in the industry;Prepares students for work in the industry, refining their skills for the production of critical medications.Audience Researchers and pharmacy students in biomedical engineering and chemical engineering, biotechnology, as well as pharmaceutical and biopharmaceutical industry engineers working in drug discovery, chemical biology, computational chemistry, medicinal chemistry, and bioinformatics.

The book is essential for anyone interested in vaccine development, as it highlights the unique advantages of viral vector vaccines in triggering robust, long-lasting immunity and provides an in-depth exploration of the technology and advancements shaping the future of healthcare. Viral vector vaccines have several unique advantages when compared to other vaccine platforms. These powerful vaccines are capable of triggering long-lasting cellular responses, such as cytotoxic T-lymphocytes, that eradicate virus-infected cells. Viral vector-based vaccines use a harmless virus to smuggle the instructions for making antigens from the disease-causing virus into cells, triggering protective immunity against them. In contrast to conventional antigen-containing vaccines, these vaccines use the body’s natural defense system to produce antigens by using a modified virus to deliver genetic code for an antigen. Viral Vectors for Vaccine Delivery provides a comprehensive overview of viral vectors and their applications in vaccine delivery. Its chapters explore various aspects of viral vector technology, from the basic principles of viral vector construction to the latest advancements in gene editing and manufacturing. Readers will find that the book Offers a deep dive into the world of viral vectors, covering their principles, applications, and potential impact on healthcare;Explores how viral vectors are revolutionizing vaccine development, providing a more effective and targeted approach to disease prevention;Discusses the potential of viral vectors to address emerging health challenges and contribute to a healthier world.Audience Research scholars, pharma-process engineers, research scientists, pharmacy students and professionals from the pharmaceutical and biopharmaceutical industry interested in drug discovery, chemical biology, computational chemistry, medicinal chemistry, and bioinformatics

This book is an indispensable guide for anyone looking to understand how AI, machine learning, and data science are revolutionizing drug discovery, development, and delivery, offering practical insights and addressing crucial real-world applications and considerations. Data Science in Pharmaceutical Development offers a comprehensive and forward-looking exploration of how artificial intelligence, machine learning, and data science are reshaping the pharmaceutical landscape. From the earliest stages of drug discovery to advanced delivery systems and post-market surveillance, this volume bridges the gap between innovation and real-world application. Practical examples and case studies bring to life the transformative potential of AI-powered tools in accelerating research, enhancing patient outcomes, and improving efficiency throughout the pharmaceutical product lifecycle. Designed for researchers, industry professionals, and students alike, this book not only showcases cutting-edge technologies but also addresses the ethical, legal, and regulatory considerations critical to their implementation. Whether you’re navigating the complexities of clinical trials, optimizing supply chains, or seeking to understand the implications of smart drug delivery systems, this book is an indispensable guide to the future of medicine and healthcare innovation. Readers will find the book: Explores the role of AI, machine learning, and data science across the entire pharmaceutical pipeline—from drug discovery and clinical trials to smart drug delivery systems;Rich with real-world case studies and practical examples, connecting theory to implementation in modern pharmaceutical research and development;Introduces advanced topics like predictive modeling, personalized medicine, IoT, pharmacovigilance, and nanotechnology-enabled drug delivery;Highlights emerging trends, ethical considerations, and the regulatory framework surrounding AI in healthcare.Audience Research scholars, pharmacy students, pharmaceutical process engineers, and pharmacy professionals in the pharmaceutical and biopharmaceutical industry who are working in drug discovery, chemical biology, computational chemistry, medicinal chemistry, and bioinformatics.

Parenteral delivery of hydrophobic drugs is a challenging task. Research on exploiting newer approachesto make the delivery of pharmaceuticals by nondigestive tracts effective yet safe and cost effective showsthat microemulsion is one such approach for parenteral delivery. This new book provides systematicinformation regarding the preformulation of drugs, formulation using quality by design (QbD) principles,and characterization of parenteral microemulsions for drug delivery. The book explores specific aspectsof microemulsions such as the role of surfactants and cosurfactants in formulation, clinical aspects ofparenteral microemulsion, regulatory perspectives and patents, as well as future challenges in this fieldof research.

SARS-CoV-2, the coronavirus responsible for COVID-19, wreaked havoc on the world; it could both spread easily and mutate rapidly, leading to the decrease in the effectiveness of newly developed vaccines over time. The detection of these mutated variants and the development of more efficient vaccines requires significant effort and increased knowledge in this field. This new book, SARS-CoV-2 Variants and Global Population Vulnerability: Diagnostic Strategies, Vaccine Development, and Therapeutic Management, provides detailed and systemic information regarding the biology and immunophysiology of SARS-CoV-2 and highlights the global vulnerability of the world population to SARS-CoV-2 infection and COVID-19.The book covers different aspects pertaining to the SARS-CoV-2 variants and their relation to global vulnerability. Chapters discuss the diagnostics, vaccine development, and therapeutic management starting from the zoonotic origin, organization, and transmission of SARS-CoV-2, lifestyle and immunophysiology of the virus, detection and diagnosis techniques, and analytical techniques. The book also observes the global impact of Delta and Omicron SARS-CoV-2 variants. It looks at the drug repurposing and new drug discovery routines for the emerging variants. It presents strategies for fast-track vaccine development, the roles of nasal vaccines and nucleic acid vaccines for COVID-19 management, monoclonal antibody therapy for the diseases management, along with the use of dietary supplements and nutraceuticals, herbal drugs, and other alternative remedies for COVID-19 management. The book also considers the social and environmental impacts of SARS-CoV-2 variants and the current challenges, outlining aspects that can help in developing more efficacious means for controlling SARS-CoV-2 in the future.Key highlights:Discusses SARS-CoV-2 variants, diagnosis strategies, vaccine development, and the therapeutic management of the diseaseProvides comprehensive coverage of SARS-CoV-2 virus and variantsWith its unique and thorough take on the subject, this book is an important resource of know-how for investigators working in this area. Professionals from the pharmaceutical industry as well as students, research scholars, doctors, and other healthcare professionals will find this book of particular value.

New innovative treatment methods in pharmaceutical technology have the potential to revolutionize healthcare, offering newfound hope to patients with conditions that were once thought to be incurable. This comprehensive new two-volume reference provides detailed explanations of the procedures involved in the development and manufacture of biopharmaceuticals as well as the uses and applications in healthcare and medicine.The books cover the uses of novel technologies for production, formulation, and synthesis of biological substances from the living organisms, which act as drug molecules for the treatment and/or prevention of various diseases and/or syndromes. Expanding beyond the scope of manufacturing, the books also explore the practical uses of biopharmaceuticals, demonstrating their effectiveness in the treatment of various illnesses, such as cancer, autoimmune disorders, and infectious diseases. The books also delve into the difficulties and possibilities linked to the advancement of biopharmaceuticals, offering valuable perspectives on the future of this swiftly changing domain.Volume 1: Exploring Cutting-Edge Innovations and Applications first offers an introduction and overview of pharmaceutical technology, covering the principals and science of biotechnology. It then goes on to discuss specific pharmaceutical biotechnologies, including:genetic engineering, a process that uses laboratory-based technologies to alter the DNA makeup of an organism;protein engineering, to develop valuable proteins through the design and production of unnatural polypeptides;recombinant DNA technology, which involves using enzymes and various laboratory techniques to manipulate and isolate DNA segments of interest; andmicrobial biotransformation, which is vital to human survival because it transforms absorbed nutrients (food, oxygen, etc.) into substances required for normal body functions.Volume 2: Current Developments in Biopharmaceuticals delves further into pharmaceutical technology, covering a broad range of specialized areas, includingbiotherapeutics, or drug therapy products where the active substance is extracted or produced from a biological source;the principals and science of vaccinology, for the prevention of many known diseases and for the development of vaccines for new diseases;bioprocess and fermentation technology, which utilizes microorganisms and enzymes to produce compounds that can be used in pharmaceutical development;analytical techniques for biologics characterization, to help provide an understanding of the physical and chemical properties of biopharmaceutical materials;regulatory approvals and patent challenges, such as, for example, balancing an interest for safety and efficacy with an interest for timely access;blood and blood-derived products, such as whole blood and other blood components for transfusion, and plasma-derived medicinal products (PDMPs);advanced enzyme technology, for the production, isolation, purification, and use of enzymes either in the soluble or immobilized form for medical purposes;advanced gene therapy in clinical management, which involves replacing or inactivating disease-causing genes or to introduce new genes to treat a specific disease;advanced cell therapies in clinical management, which involves transplantation of human cells to replace or repair damaged tissue and/or cells.With the comprehensive coverage presented here, the two-volume Advances in Pharmaceutical Biotechnology will be an invaluable reference book for the students of pharmacy and biotechnology as well as an excellent resource for pharmacy industry professionals and others.

This comprehensive new two-volume work provides detailed explanations of the procedures involvedin the development and manufacture of biopharmaceuticals as well as the uses and applications in healthcare and medicine.Volume 1 offers an introduction and overview of pharmaceutical technology, covering the principals and science of biotechnology. It explains genetic engineering that involves laboratory-based technologies to alter the DNA makeup of an organism; protein engineering to develop valuable proteins through the design and production of unnatural polypeptides; recombinant DNA technology to manipulate and isolate DNA segments of interest; and microbial biotransformation, which transforms absorbed nutrients (food, oxygen, etc.) into substances required for normal body functions

This comprehensive new two-volume work provides detailed explanations of the procedures involved in the development and manufacture of biopharmaceuticals as well as the uses and applications in healthcare and medicine.Volume 1 offers an introduction and overview of pharmaceutical technology, covering the principals and science of biotechnology. It explains genetic engineering that involves laboratory-based technologies to alter the DNA makeup of an organism; protein engineering to develop valuable proteins through the design and production of unnatural polypeptides; recombinant DNA technology to manipulate and isolate DNA segments of interest; and microbial biotransformation, which transforms absorbed nutrients (food, oxygen, etc.) into substances required for normal body functions.

One of the most significant discoveries in the field of immunology and medicine in recent times is the enigmatic realm of exosomes. Exosomes, which range in size from 30 to 150 nm, are specific types of extracellular vesicles that are released by nearly all cells. Over the past decade, there has been a significant increase in the detection and understanding of exosomes and how they can be incorporated into the development of innovative therapeutic applications and their role in diagnostic assessments and pathophysiological mechanisms.Covering a wide realm of topics on extracellular vesicles, this book provides an in-depth understanding of the multifunctionality of exosomes that has created novel opportunities for precision medicine, providing individualized strategies for the detection, therapy, and surveillance of many medical conditions. It explores the diverse roles and features exhibited by cells based on their origin, delving into the intricate mechanisms that govern exosome biogenesis and cargo loading while also shedding light on their roles as molecular couriers. The significant and diverse potential of exosomes and extracellular vesicles in the context of managing and combatting various diseases and health are discussed, such as for site-specific drug delivery and vaccine delivery; for cancer management; for the treatment of cardiovascular diseases, neurodegenerative diseases, infectious diseases, dermal ailments, and ophthalmic ailments; in reproductive medicines; and in regenerative medicines; as well as in gene therapy and personalized care. A chapter also addresses the regulatory aspects and concerns regarding exosome-based drug delivery.

This new book, Advanced Drug Delivery Strategies via Microbial Cargos and Their Derivatives, dives into the fascinating field of microbial entities serving as carriers for therapeutic payloads, revealing a wide range of options for revolutionizing drug delivery.In this volume, experts from around the world provide a comprehensive overview of the many important aspects of microbial drug delivery systems as well as insights on strategies for the development of innovative microbial cargos using the beneficial properties of microorganisms and their derivatives. The chapters present a wide variety of carrier systems obtained using microorganisms or their derivatives. It explores how advanced carrier models like synthetic microbes are being developed as drug delivery systems. Pre-clinical and clinical studies as well as regulatory perspectives are also emphasized in the book, which will aid in the development of more successful drug delivery carriers, which will also result in a more cost-effective process overall.The volume first provides an introduction to advanced drug delivery systems using microbial cargo and derivatives and then delves into specifics, such as bacterial cellulose-based drug delivery systems, biotic components for oral drug delivery and oral vaccination, virus-based drug delivery systems, synthetic microbes as drug delivery systems, the safety and regulatory aspects of these drug delivery systems, and more.This volume provides a plethora of information for researchers to investigate the intricacies of microbial drug delivery systems, such as varied cargo types and individual variations. This book will be an invaluable resource for students, giving them a concise grasp of fundamental concepts and most recent developments in these rapidly expanding rules and regulations.

Tuberculosis is a major global health threat even today, claiming the lives of millions each year, despite the availability of effective treatments for the disease. The emergence of drug resistance and limitations of existing therapies demand the continuous development of new and improved drugs. This new book provides a comprehensive overview of the latest progress in this field, covering state-of-the-art approaches to untangle the complexities of drug resistance.The book explores diagnosis methods, drug resistance mechanisms, and limitations in existing drugs and proposes strategies such as structural modifications, efflux pathway targeting, and host-directed therapies to overcome resistance. It also looks at artificial intelligence for TB management. Recent advancements in tuberculosis control, vaccine development, and biomarkers are also covered along with visions for the future of TB drug discovery, offering a glimpse into the evolving landscape of combating tuberculosis.