Krishnan Anand - Böcker

This detailed volume navigates the journey from a promising chemical entity to a potential therapeutic agent in cancer research through systematic and rigorous protocols across a spectrum of increasingly sophisticated models. Beginning with foundational in vitro assays for assessing cytotoxicity and antiproliferative effects, the book continues by covering mechanisms of action studies, advanced 2D and 3D culture models for the tumor microenvironment and cellular architecture involved in modulating drug response and resistance, in vivo antitumor and efficacy models, as well as immunology and inflammation-related assays and forward-looking clinical studies for cancer research. Written for the Springer Protocols Handbooks series, chapters include the kind of precise implementation advice and methodological clarity that leads to success in advancing the current state of the research.Comprehensive and practical, Advanced Protocols in Cancer Research: Translational Models for Antitumor and Anticancer Drug Discovery serves as a valuable resource for fostering methodological precision and accelerating the translation of scientific discovery into effective cancer therapies.

BIOINFORMATICS TOOLS FOR Pharmaceutical DRUG PRODUCT DLEVELOPMENT A timely book that details bioinformatics tools, artificial intelligence, machine learning, computational methods, protein interactions, peptide-based drug design, and omics technologies, for drug development in the pharmaceutical and medical sciences industries. The book contains 17 chapters categorized into 3 sections. The first section presents the latest information on bioinformatics tools, artificial intelligence, machine learning, computational methods, protein interactions, peptide-based drug design, and omics technologies. The following 2 sections include bioinformatics tools for the pharmaceutical sector and the healthcare sector. Bioinformatics brings a new era in research to accelerate drug target and vaccine design development, improving validation approaches as well as facilitating and identifying side effects and predicting drug resistance. As such, this will aid in more successful drug candidates from discovery to clinical trials to the market, and most importantly make it a more cost-effective process overall. Readers will find in this book: Applications of bioinformatics tools for pharmaceutical drug product development like process development, pre-clinical development, clinical development, commercialization of the product, etc.; The ever-expanding application of this novel technology and discusses some of the unique challenges associated with such an approach;The broad and deep background, as well as updates, on recent advances in both medicine and AI/ML that enable the application of these cutting-edge bioinformatics tools.Audience The book will be used by researchers and scientists in academia and industry including drug developers, computational biochemists, bioinformaticians, immunologists, pharmaceutical and medical sciences, as well as those in artificial intelligence and machine learning.

This book presents the Proceedings of ICON–2019, an international meeting exclusively dedicated to nanostructured materials in medicinal applications. The conference emphasized the recent advances in multidisciplinary research on processing, morphol¬ogy, structure and properties of nanostructured materials and their applications in vari¬ous medicinal fields. The papers encompass basic studies and applications and address topics of novel issues, difficulties, and breakthroughs in the field of nanomedicine in cancer, tuberculosis, tissue engineering, regenerative medicine etc.

This book presents the Proceedings of ICON–2019, an international meeting exclusively dedicated to nanostructured materials in medicinal applications.

These products may be used as alternatives to animal-derived and synthetic chemical products to develop new therapeutic and diagnostic approaches with greater eco-friendliness and sustainability, according to new research.

Biomaterials play a vital role in medicine today, including restoring function and facilitating diagnosis and disease prevention. Biomaterial-based products consist of either natural or synthetic materials. Biomaterials derived from natural products can consist of materials such as proteins, polysaccharides, lipids, glycoproteins, lipoproteins, cellular matrix, and its components. These products may be used as alternatives to animal-derived and synthetic chemical products to develop new therapeutic and diagnostic approaches with greater eco-friendliness and sustainability, according to new research. They are also biocompatible, biodegradable, renewable, non-toxic, and capable of remodelling.Recently, scientists have been exploring the potential use of plant-based cellular matrix-based biomaterials for the treatment of various communicable and noncommunicable diseases, a trend that has attracted the attention of global biomedical research. Globally, there has been an increase in the need for more effective treatment and diagnostics as a result of the overwhelming disease burden in society. Current Applications of Nanobiomaterials, Volume 1 and Volume 2 together, outline the most widely used biomaterials derived from non-animal natural resources, such as plants, fungi, algae, and microbes, with a focus on novel therapeutic and diagnostic applications.

This book provides a comprehensive overview of the role of exosomes in brain diseases, including stroke, multiple sclerosis, Parkinson's disease, Alzheimer's disease, epilepsy, and depression. It covers the basics of exosome biogenesis, composition, and synthesis, as well as the therapeutic potential of exosomes in brain disorders. The correlation between exosomes and neuroinflammation, the challenges of using exosomes as a novel carrier, and engineered exosomes to deliver therapeutic protein are covered well in this book. Use of radiolabelled exosomes as a diagnostic tool and the toxicity studies of exosomes with potential overcome approaches. It is an essential resource for researchers, clinicians, and healthcare professionals working in the field of exosome research, especially on its applications in brain disorders.

This book provides a comprehensive overview of the role of exosomes in brain diseases, including stroke, multiple sclerosis, Parkinson's disease, Alzheimer's disease, epilepsy, and depression.