Karuppusamy Arunachalam – författare

This detailed book explores protocols for a wide array of preclinical pharmacology and toxicology evaluations to be applied to chemical drugs and their development through in vitro, involving tissues and cell lines, and in vivo models, using animals as experimental systems, utilized to conduct pharmacological research. Written for the Springer Protocols Handbooks series, the methodologies included in this collection have been standardized by the authors through extensive use in the lab so that they are ready to be applied in the labs of readers around the world. Authoritative and practical, Bioassays in Experimental and Preclinical Pharmacology aims to assist undergraduate and postgraduate students, research scholars, scientists, and other academicians performing research in the vital field of drug discovery.

This detailed book explores protocols for a wide array of preclinical pharmacology and toxicology evaluations to be applied to chemical drugs and their development through in vitro, involving tissues and cell lines, and in vivo models, using animals as experimental systems, utilized to conduct pharmacological research. Written for the Springer Protocols Handbooks series, the methodologies included in this collection have been standardized by the authors through extensive use in the lab so that they are ready to be applied in the labs of readers around the world. Authoritative and practical, Bioassays in Experimental and Preclinical Pharmacology aims to assist undergraduate and postgraduate students, research scholars, scientists, and other academicians performing research in the vital field of drug discovery.

This detailed book explores protocols for a wide array of preclinical pharmacology and toxicology evaluations to be applied to chemical drugs and their development through in vitro, involving tissues and cell lines, and in vivo models, using animals as experimental systems, utilized to conduct pharmacological research. Written for the Springer Protocols Handbooks series, the methodologies included in this collection have been standardized by the authors through extensive use in the lab so that they are ready to be applied in the labs of readers around the world. Authoritative and practical, Bioassays in Experimental and Preclinical Pharmacology aims to assist undergraduate and postgraduate students, research scholars, scientists, and other academicians performing research in the vital field of drug discovery.

This detailed volume explores a wide range of evidence-based complementary medicine and various bio-analytical techniques used to define botanical products. Collecting recent work and current developments in the field of contemporary phytomedicine as well as their future possibilities in human health care, the book includes unique contributions in the form of chapters on phytomedicine and screening biological activities explained with diverse hyphenated techniques, as well as issues related to herbal medications, such as efficacy, adulteration, safety, toxicity, regulations, and drug delivery. Written for the Springer Protocols Handbooks series, chapters feature advice from experts on how to best conduct future experiments. Extensive and practical, Natural Product Experiments in Drug Discovery serves as an ideal reference for students, professors, and researchers in universities, R&D institutes, pharmaceutical and herbal enterprises, andhealth organizations.

This detailed volume explores a wide range of evidence-based complementary medicine and various bio-analytical techniques used to define botanical products. Collecting recent work and current developments in the field of contemporary phytomedicine as well as their future possibilities in human health care, the book includes unique contributions in the form of chapters on phytomedicine and screening biological activities explained with diverse hyphenated techniques, as well as issues related to herbal medications, such as efficacy, adulteration, safety, toxicity, regulations, and drug delivery. Written for the Springer Protocols Handbooks series, chapters feature advice from experts on how to best conduct future experiments. Extensive and practical, Natural Product Experiments in Drug Discovery serves as an ideal reference for students, professors, and researchers in universities, R&D institutes, pharmaceutical and herbal enterprises, andhealth organizations.

This detailed volume explores a wide range of evidence-based complementary medicine and various bio-analytical techniques used to define botanical products. Collecting recent work and current developments in the field of contemporary phytomedicine as well as their future possibilities in human health care, the book includes unique contributions in the form of chapters on phytomedicine and screening biological activities explained with diverse hyphenated techniques, as well as issues related to herbal medications, such as efficacy, adulteration, safety, toxicity, regulations, and drug delivery. Written for the Springer Protocols Handbooks series, chapters feature advice from experts on how to best conduct future experiments. Extensive and practical, Natural Product Experiments in Drug Discovery serves as an ideal reference for students, professors, and researchers in universities, R&D institutes, pharmaceutical and herbal enterprises, andhealth organizations.

This detailed volume explores laboratory protocols and methodologies for studying cell cultures, genetic analysis, and various biochemical assays. The chapters within this book cover a wide range of techniques, from basic cell culture methods to more specialized assays used in the study of genotoxicity, apoptosis, and gene expression, not only relevant to academic researchers but also to professionals in the pharmaceutical, biotechnological, and clinical fields. Written for the Springer Protocols Handbooks series, each protocol has been carefully compiled to provide step-by-step instructions, ensuring clarity and reproducibility.  Authoritative and practical, Advanced Cell and Molecular Techniques: Protocols for In Vitro and In Vivo Studies serves as both a hands-on guide and a source of inspiration for future research as the fields of molecular biology and toxicology continue to evolve.

This detailed volume navigates the journey from a promising chemical entity to a potential therapeutic agent in cancer research through systematic and rigorous protocols across a spectrum of increasingly sophisticated models. Beginning with foundational in vitro assays for assessing cytotoxicity and antiproliferative effects, the book continues by covering mechanisms of action studies, advanced 2D and 3D culture models for the tumor microenvironment and cellular architecture involved in modulating drug response and resistance, in vivo antitumor and efficacy models, as well as immunology and inflammation-related assays and forward-looking clinical studies for cancer research. Written for the Springer Protocols Handbooks series, chapters include the kind of precise implementation advice and methodological clarity that leads to success in advancing the current state of the research.Comprehensive and practical, Advanced Protocols in Cancer Research: Translational Models for Antitumor and Anticancer Drug Discovery serves as a valuable resource for fostering methodological precision and accelerating the translation of scientific discovery into effective cancer therapies.

This book focuses on natural products, in particular medicinal plants and their derived products, as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery . There are several advantages for plant-derived therapeutics, including wide availability, diverse pharmacological actions, and a generally good profile of safety and tolerability. Over the recent years, there have been numerous reports from clinical studies testifying the efficacy and safety of medicinal plants and phytochemicals in treating human diseases. A plethora of basic studies has also unraveled molecular mechanisms underlying the health benefits of herbal medicines. Nevertheless, issues such as identification of bioactive ingredients, standardization of the products, and drug interactions remain to be systematically documented. Bioprospecting of Tropical Medicinal Plants represents a comprehensive analysis of natural products, mainly medicinal plants and phytochemicals. It includes detailed medicinal properties and pharmacological action from in vitro models to clinical trials. The goal is to present the readers a carefully curated collection of plant-derived natural products and their underlying molecular mechanisms.

This book focuses on natural products, in particular medicinal plants and their derived products, as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery . There are several advantages for plant-derived therapeutics, including wide availability, diverse pharmacological actions, and a generally good profile of safety and tolerability. Over the recent years, there have been numerous reports from clinical studies testifying the efficacy and safety of medicinal plants and phytochemicals in treating human diseases. A plethora of basic studies has also unraveled molecular mechanisms underlying the health benefits of herbal medicines. Nevertheless, issues such as identification of bioactive ingredients, standardization of the products, and drug interactions remain to be systematically documented. Bioprospecting of Tropical Medicinal Plants represents a comprehensive analysis of natural products, mainly medicinal plants and phytochemicals. It includes detailed medicinal properties and pharmacological action from in vitro models to clinical trials. The goal is to present the readers a carefully curated collection of plant-derived natural products and their underlying molecular mechanisms.

This book focuses on natural products, in particular medicinal plants and their derived products, as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery . There are several advantages for plant-derived therapeutics, including wide availability, diverse pharmacological actions, and a generally good profile of safety and tolerability. Over the recent years, there have been numerous reports from clinical studies testifying the efficacy and safety of medicinal plants and phytochemicals in treating human diseases. A plethora of basic studies has also unraveled molecular mechanisms underlying the health benefits of herbal medicines. Nevertheless, issues such as identification of bioactive ingredients, standardization of the products, and drug interactions remain to be systematically documented. Bioprospecting of Tropical Medicinal Plants represents a comprehensive analysis of natural products, mainly medicinal plants and phytochemicals. It includes detailed medicinal properties and pharmacological action from in vitro models to clinical trials. The goal is to present the readers a carefully curated collection of plant-derived natural products and their underlying molecular mechanisms.

Ethnobiology and Development in Asia: The Belt and Road Initiative offers a groundbreaking perspective on the interplay between traditional knowledge, cultural practices, and biological resources along historical and contemporary trade routes across Asia. Against the backdrop of an interlinked climate, biodiversity, and land degradation crisis, generating robust knowledge that includes local and indigenous perspectives is crucial. This book explores how communities across diverse ecological zones interact with their environment, how species and cultures have moved along the Belt and Road, and how grassroots initiatives are driving sustainable development.Structured into three key sections - Common species and cultures along the Belt and Road, Flows of species and cultures, and Community-based initiatives - this volume presents a novel interpretation of the Belt and Road Initiative through an ethnobiological lens. From the Arctic tundra to tropical rainforests, from ancient silk routes to maritime trading paths, from rural places to urban settings, 49 in-depth chapters document how people have developed sophisticated relationships with local species and ecosystems, creating a rich traditional knowledge of biological and cultural diversity. The book also emphasizes how local communities together with various stakeholders explore vibrant and innovative ways of living in harmony with nature.Aimed at researchers, policymakers, and the wider public, this book underscores the value of traditional knowledge in global discussions on climate change and biodiversity conservation. It calls for urgent action to respect and protect indigenous knowledge systems and contributes to the implementation of the Convention on Biological Diversity (CBD) and the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES)' integrated approach to biodiversity and ecosystem services. Through its detailed ethnobiological analysis, this book offers a practical guide for integrating traditional knowledge into mainstream conservation and development strategies, thereby supporting sustainable community development along the Belt and Road.

Ethnobiology and Development in Asia: The Belt and Road Initiative offers a groundbreaking perspective on the interplay between traditional knowledge, cultural practices, and biological resources along historical and contemporary trade routes across Asia. Against the backdrop of an interlinked climate, biodiversity, and land degradation crisis, generating robust knowledge that includes local and indigenous perspectives is crucial. This book explores how communities across diverse ecological zones interact with their environment, how species and cultures have moved along the Belt and Road, and how grassroots initiatives are driving sustainable development.Structured into three key sections - Common species and cultures along the Belt and Road, Flows of species and cultures, and Community-based initiatives - this volume presents a novel interpretation of the Belt and Road Initiative through an ethnobiological lens. From the Arctic tundra to tropical rainforests, from ancient silk routes to maritime trading paths, from rural places to urban settings, 49 in-depth chapters document how people have developed sophisticated relationships with local species and ecosystems, creating a rich traditional knowledge of biological and cultural diversity. The book also emphasizes how local communities together with various stakeholders explore vibrant and innovative ways of living in harmony with nature.Aimed at researchers, policymakers, and the wider public, this book underscores the value of traditional knowledge in global discussions on climate change and biodiversity conservation. It calls for urgent action to respect and protect indigenous knowledge systems and contributes to the implementation of the Convention on Biological Diversity (CBD) and the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES)' integrated approach to biodiversity and ecosystem services. Through its detailed ethnobiological analysis, this book offers a practical guide for integrating traditional knowledge into mainstream conservation and development strategies, thereby supporting sustainable community development along the Belt and Road.

Biomaterials play a vital role in medicine today, including restoring function and facilitating diagnosis and disease prevention. Biomaterial-based products consist of either natural or synthetic materials. Biomaterials derived from natural products can consist of materials such as proteins, polysaccharides, lipids, glycoproteins, lipoproteins, cellular matrix, and its components. These products may be used as alternatives to animal-derived and synthetic chemical products to develop new therapeutic and diagnostic approaches with greater eco-friendliness and sustainability, according to new research. They are also biocompatible, biodegradable, renewable, non-toxic, and capable of remodelling.Recently, scientists have been exploring the potential use of plant-based cellular matrix-based biomaterials for the treatment of various communicable and noncommunicable diseases, a trend that has attracted the attention of global biomedical research. Globally, there has been an increase in the need for more effective treatment and diagnostics as a result of the overwhelming disease burden in society. Current Applications of Nanobiomaterials, Volume 1 and Volume 2 together, outline the most widely used biomaterials derived from non-animal natural resources, such as plants, fungi, algae, and microbes, with a focus on novel therapeutic and diagnostic applications.

Biomaterials play a vital role in medicine today, including restoring function and facilitating diagnosis and disease prevention. Biomaterial-based products consist of either natural or synthetic materials. Biomaterials derived from natural products can consist of materials such as proteins, polysaccharides, lipids, glycoproteins, lipoproteins, cellular matrix, and its components. These products may be used as alternatives to animal-derived and synthetic chemical products to develop new therapeutic and diagnostic approaches with greater eco-friendliness and sustainability, according to new research. They are also biocompatible, biodegradable, renewable, non-toxic, and capable of remodelling.Recently, scientists have been exploring the potential use of plant-based cellular matrix-based biomaterials for the treatment of various communicable and noncommunicable diseases, a trend that has attracted the attention of global biomedical research. Globally, there has been an increase in the need for more effective treatment and diagnostics as a result of the overwhelming disease burden in society. Current Applications of Nanobiomaterials, Volume 1 and Volume 2 together, outline the most widely used biomaterials derived from non-animal natural resources, such as plants, fungi, algae, and microbes, with a focus on novel therapeutic and diagnostic applications.

Biomaterials play a vital role in medicine today, including restoring function and facilitating diagnosis and disease prevention. Biomaterial-based products consist of either natural or synthetic materials. Biomaterials derived from natural products can consist of materials such as proteins, polysaccharides, lipids, glycoproteins, lipoproteins, cellular matrix, and its components. These products may be used as alternatives to animal-derived and synthetic chemical products to develop new therapeutic and diagnostic approaches with greater eco-friendliness and sustainability, according to new research. They are also biocompatible, biodegradable, renewable, non-toxic, and capable of remodelling.Recently, scientists have been exploring the potential use of plant-based cellular matrix-based biomaterials for the treatment of various communicable and noncommunicable diseases, a trend that has attracted the attention of global biomedical research. Globally, there has been an increase in the need for more effective treatment and diagnostics as a result of the overwhelming disease burden in society. Current Applications of Nanobiomaterials, Volume 1 and Volume 2 together, outline the most widely used biomaterials derived from non-animal natural resources, such as plants, fungi, algae, and microbes, with a focus on novel therapeutic and diagnostic applications.

Biomaterials play a vital role in medicine today, including restoring function and facilitating diagnosis and disease prevention. Biomaterial-based products consist of either natural or synthetic materials. Biomaterials derived from natural products can consist of materials such as proteins, polysaccharides, lipids, glycoproteins, lipoproteins, cellular matrix, and its components. These products may be used as alternatives to animal-derived and synthetic chemical products to develop new therapeutic and diagnostic approaches with greater eco-friendliness and sustainability, according to new research. They are also biocompatible, biodegradable, renewable, non-toxic, and capable of remodelling.Recently, scientists have been exploring the potential use of plant-based cellular matrix-based biomaterials for the treatment of various communicable and noncommunicable diseases, a trend that has attracted the attention of global biomedical research. Globally, there has been an increase in the need for more effective treatment and diagnostics as a result of the overwhelming disease burden in society. Current Applications of Nanobiomaterials, Volume 1 and Volume 2 together, outline the most widely used biomaterials derived from non-animal natural resources, such as plants, fungi, algae, and microbes, with a focus on novel therapeutic and diagnostic applications.

Ethnobiology and Development in Asia: The Belt and Road Initiative offers a groundbreaking perspective on the interplay between traditional knowledge, cultural practices, and biological resources along historical and contemporary trade routes across Asia. Against the backdrop of an interlinked climate, biodiversity, and land degradation crisis, generating robust knowledge that includes local and indigenous perspectives is crucial. This book explores how communities across diverse ecological zones interact with their environment, how species and cultures have moved along the Belt and Road, and how grassroots initiatives are driving sustainable development.Structured into three key sections - Common species and cultures along the Belt and Road, Flow of species and cultures along the Belt and Road, and Community-based initiatives along the Belt and Road - this volume presents a novel interpretation of the Belt and Road Initiative through an ethnobiological lens. From the Arctic tundra to tropical rainforests, from ancient silk routes to maritime trading paths, from rural places to urban settings, 49 in-depth chapters document how people have developed sophisticated relationships with local species and ecosystems, creating a rich traditional knowledge of biological and cultural diversity. The book also emphasizes how local communities together with various stakeholders explore vibrant and innovative ways of living in harmony with nature.Aimed at researchers, policymakers, and the wider public, this book underscores the value of traditional knowledge in global discussions on climate change and biodiversity conservation. It calls for urgent action to respect and protect indigenous knowledge systems and contributes to the implementation of the Convention on Biological Diversity (CBD) and the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES)' integrated approach to biodiversity and ecosystem services. Through its detailed ethnobiological analysis, this book offers a practical guide for integrating traditional knowledge into mainstream conservation and development strategies, thereby supporting sustainable community development along the Belt and Road.

Ethnobiology and Development in Asia: The Belt and Road Initiative offers a groundbreaking perspective on the interplay between traditional knowledge, cultural practices, and biological resources along historical and contemporary trade routes across Asia. Against the backdrop of an interlinked climate, biodiversity, and land degradation crisis, generating robust knowledge that includes local and indigenous perspectives is crucial. This book explores how communities across diverse ecological zones interact with their environment, how species and cultures have moved along the Belt and Road, and how grassroots initiatives are driving sustainable development.Structured into three key sections - Common species and cultures along the Belt and Road, Flow of species and cultures along the Belt and Road, and Community-based initiatives along the Belt and Road - this volume presents a novel interpretation of the Belt and Road Initiative through an ethnobiological lens. From the Arctic tundra to tropical rainforests, from ancient silk routes to maritime trading paths, from rural places to urban settings, 49 in-depth chapters document how people have developed sophisticated relationships with local species and ecosystems, creating a rich traditional knowledge of biological and cultural diversity. The book also emphasizes how local communities together with various stakeholders explore vibrant and innovative ways of living in harmony with nature.Aimed at researchers, policymakers, and the wider public, this book underscores the value of traditional knowledge in global discussions on climate change and biodiversity conservation. It calls for urgent action to respect and protect indigenous knowledge systems and contributes to the implementation of the Convention on Biological Diversity (CBD) and the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES)' integrated approach to biodiversity and ecosystem services. Through its detailed ethnobiological analysis, this book offers a practical guide for integrating traditional knowledge into mainstream conservation and development strategies, thereby supporting sustainable community development along the Belt and Road.

Green Nanotechnology: Innovations and Applications in Biofuels, Environmental Management, and Healthcare is a comprehensive exploration of the cutting-edge research and developments in the field of green nanotechnology. This book delves into the integration of sustainable nanomaterials in diverse industries, focusing on their transformative potential in biofuel production, wastewater management, and therapeutic applications. With the global push for sustainability and eco-friendly solutions, green nanotechnology presents a unique avenue for addressing environmental and health-related challenges, while contributing to the development of cleaner, more efficient technologies. This book presents a collection of chapters from leading experts in the field, covering various facets of green nanotechnology, from biofuels to environmental remediation, and biomedical advancements. It provides a rich blend of theoretical insights and practical applications, making it an essential resource for researchers, engineers, healthcare professionals, and students alike.