Karuppusamy Arunachalam – författare

This detailed book explores protocols for a wide array of preclinical pharmacology and toxicology evaluations to be applied to chemical drugs and their development through in vitro, involving tissues and cell lines, and in vivo models, using animals as experimental systems, utilized to conduct pharmacological research.

This detailed book explores protocols for a wide array of preclinical pharmacology and toxicology evaluations to be applied to chemical drugs and their development through in vitro, involving tissues and cell lines, and in vivo models, using animals as experimental systems, utilized to conduct pharmacological research.

This detailed volume explores a wide range of evidence-based complementary medicine and various bio-analytical techniques used to define botanical products. Collecting recent work and current developments in the field of contemporary phytomedicine as well as their future possibilities in human health care, the book includes unique contributions in the form of chapters on phytomedicine and screening biological activities explained with diverse hyphenated techniques, as well as issues related to herbal medications, such as efficacy, adulteration, safety, toxicity, regulations, and drug delivery. Written for the Springer Protocols Handbooks series, chapters feature advice from experts on how to best conduct future experiments. Extensive and practical, Natural Product Experiments in Drug Discovery serves as an ideal reference for students, professors, and researchers in universities, R&D institutes, pharmaceutical and herbal enterprises, andhealth organizations.

This detailed volume explores a wide range of evidence-based complementary medicine and various bio-analytical techniques used to define botanical products. Collecting recent work and current developments in the field of contemporary phytomedicine as well as their future possibilities in human health care, the book includes unique contributions in the form of chapters on phytomedicine and screening biological activities explained with diverse hyphenated techniques, as well as issues related to herbal medications, such as efficacy, adulteration, safety, toxicity, regulations, and drug delivery. Written for the Springer Protocols Handbooks series, chapters feature advice from experts on how to best conduct future experiments. Extensive and practical, Natural Product Experiments in Drug Discovery serves as an ideal reference for students, professors, and researchers in universities, R&D institutes, pharmaceutical and herbal enterprises, andhealth organizations.

mso-bidi-language: AR-SA;">Authoritative and practical, Advanced Cell and Molecular Techniques: Protocols for In Vitro and In Vivo Studies serves as both a hands-on guide and a source of inspiration for future research as the fields of molecular biology and toxicology continue to evolve.

This detailed volume navigates the journey from a promising chemical entity to a potential therapeutic agent in cancer research through systematic and rigorous protocols across a spectrum of increasingly sophisticated models. Beginning with foundational in vitro assays for assessing cytotoxicity and antiproliferative effects, the book continues by covering mechanisms of action studies, advanced 2D and 3D culture models for the tumor microenvironment and cellular architecture involved in modulating drug response and resistance, in vivo antitumor and efficacy models, as well as immunology and inflammation-related assays and forward-looking clinical studies for cancer research. Written for the Springer Protocols Handbooks series, chapters include the kind of precise implementation advice and methodological clarity that leads to success in advancing the current state of the research.Comprehensive and practical, Advanced Protocols in Cancer Research: Translational Models for Antitumor and Anticancer Drug Discovery serves as a valuable resource for fostering methodological precision and accelerating the translation of scientific discovery into effective cancer therapies.

This book focuses on natural products, in particular medicinal plants and their derived products, as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery .

This book focuses on natural products, in particular medicinal plants and their derived products, as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery .

Ethnobiology and Development in Asia: The Belt and Road Initiative offers a groundbreaking perspective on the interplay between traditional knowledge, cultural practices, and biological resources along historical and contemporary trade routes across Asia. Against the backdrop of an interlinked climate, biodiversity, and land degradation crisis, generating robust knowledge that includes local and indigenous perspectives is crucial. This book explores how communities across diverse ecological zones interact with their environment, how species and cultures have moved along the Belt and Road, and how grassroots initiatives are driving sustainable development.Structured into three key sections - Common species and cultures along the Belt and Road, Flows of species and cultures, and Community-based initiatives - this volume presents a novel interpretation of the Belt and Road Initiative through an ethnobiological lens. From the Arctic tundra to tropical rainforests, from ancient silk routes to maritime trading paths, from rural places to urban settings, 49 in-depth chapters document how people have developed sophisticated relationships with local species and ecosystems, creating a rich traditional knowledge of biological and cultural diversity. The book also emphasizes how local communities together with various stakeholders explore vibrant and innovative ways of living in harmony with nature.Aimed at researchers, policymakers, and the wider public, this book underscores the value of traditional knowledge in global discussions on climate change and biodiversity conservation. It calls for urgent action to respect and protect indigenous knowledge systems and contributes to the implementation of the Convention on Biological Diversity (CBD) and the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES)' integrated approach to biodiversity and ecosystem services. Through its detailed ethnobiological analysis, this book offers a practical guide for integrating traditional knowledge into mainstream conservation and development strategies, thereby supporting sustainable community development along the Belt and Road.

These products may be used as alternatives to animal-derived and synthetic chemical products to develop new therapeutic and diagnostic approaches with greater eco-friendliness and sustainability, according to new research.

Biomaterials play a vital role in medicine today, including restoring function and facilitating diagnosis and disease prevention. Biomaterial-based products consist of either natural or synthetic materials. Biomaterials derived from natural products can consist of materials such as proteins, polysaccharides, lipids, glycoproteins, lipoproteins, cellular matrix, and its components. These products may be used as alternatives to animal-derived and synthetic chemical products to develop new therapeutic and diagnostic approaches with greater eco-friendliness and sustainability, according to new research. They are also biocompatible, biodegradable, renewable, non-toxic, and capable of remodelling.Recently, scientists have been exploring the potential use of plant-based cellular matrix-based biomaterials for the treatment of various communicable and noncommunicable diseases, a trend that has attracted the attention of global biomedical research. Globally, there has been an increase in the need for more effective treatment and diagnostics as a result of the overwhelming disease burden in society. Current Applications of Nanobiomaterials, Volume 1 and Volume 2 together, outline the most widely used biomaterials derived from non-animal natural resources, such as plants, fungi, algae, and microbes, with a focus on novel therapeutic and diagnostic applications.

Ethnobiology and Development in Asia: The Belt and Road Initiative offers a groundbreaking perspective on the interplay between traditional knowledge, cultural practices, and biological resources along historical and contemporary trade routes across Asia. Against the backdrop of an interlinked climate, biodiversity, and land degradation crisis, generating robust knowledge that includes local and indigenous perspectives is crucial. This book explores how communities across diverse ecological zones interact with their environment, how species and cultures have moved along the Belt and Road, and how grassroots initiatives are driving sustainable development.Structured into three key sections - Common species and cultures along the Belt and Road, Flows of species and cultures, and Community-based initiatives - this volume presents a novel interpretation of the Belt and Road Initiative through an ethnobiological lens. From the Arctic tundra to tropical rainforests, from ancient silk routes to maritime trading paths, from rural places to urban settings, 49 in-depth chapters document how people have developed sophisticated relationships with local species and ecosystems, creating a rich traditional knowledge of biological and cultural diversity. The book also emphasizes how local communities together with various stakeholders explore vibrant and innovative ways of living in harmony with nature.Aimed at researchers, policymakers, and the wider public, this book underscores the value of traditional knowledge in global discussions on climate change and biodiversity conservation. It calls for urgent action to respect and protect indigenous knowledge systems and contributes to the implementation of the Convention on Biological Diversity (CBD) and the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES)' integrated approach to biodiversity and ecosystem services. Through its detailed ethnobiological analysis, this book offers a practical guide for integrating traditional knowledge into mainstream conservation and development strategies, thereby supporting sustainable community development along the Belt and Road.