Häftad, Engelska, 2027
1 821 kr
Kommande
Solvent Interaction Analysis: Physical Chemistry and Analytical Applications of Aqueous Two-Phase Systems explores Solvent Interaction Analysis (SIA) technology, a cutting-edge approach for protein characterization and proteomics in biological fluids. The book considers a broad spectrum of topics, from fundamental principles such as phase separation, blood-tissue distribution, and posttranslational protein modifications, to advanced clinical applications for early detection of various malignancies, neurological disorders, and other diseases. The book opens with an introduction to aqueous two-phase system (ATPS), considering different types of ATPS, hydrophobic and electrostatic properties, and mechanisms of liquid-liquid phase separation, before moving on to specific properties of phases such as solute-water interaction and blood-tissue distribution, and analysis of partitioning individual proteins. It then explores solvent interaction analysis, investigating diagnostic applications and biomarker discovery. Final chapters explore fundamental consequences of ATPS-based analysis and its future opportunities. This comprehensive guide offers a detailed overview of aqueous two-phase systems from foundational knowledge to the latest developments in the field, and is an essential reference for students, researchers and practitioners across a wide range of disciplines, including biophysics, analytical and medicinal chemistry, proteomics, structural biology, pharmaceutical science, and biotechnology.Explores real-world biomedical applications of aqueous two-phase systems, focusing on biomarker discovery and disease detectionOffers an interdisciplinary approach to solvent interaction analysis, integrating biophysics and physical chemistryInvestigates mechanisms of phase separation and its applications in biological and clinical contextsBridges foundational knowledge with advanced practical insights to enhance understanding