After completing studies for the A.B., A.M., and Ph.D. degrees in chemistry at Harvard University, David W. Christianson joined the faculty of the University of Pennsylvania, where he is currently the Roy and Diana Vagelos Professor in Chemistry and Chemical Biology. At Penn, Christianson’s research focuses on the structural and chemical biology of the zinc-dependent histone deacetylases as well as enzymes of terpene biosynthesis. His research accomplishments have been recognized by several awards, including the Pfizer Award in Enzyme Chemistry and the Repligen Award in Chemistry of Biological Processes from the American Chemical Society, a Guggenheim Fellowship, and the Elizabeth S. and Richard M. Cashin Fellowship from the Radcliffe Institute for Advanced Study at Harvard University. Christianson is also a dedicated classroom teacher, and his accomplishments in this regard have been recognized by the Lindback Award for Distinguished Teaching at Penn and a Rhodes Trust Inspirational Educator Award from Oxford University. Christianson has also held visiting professorships in the Department of Biochemistry at Cambridge University and the Department of Chemistry and Chemical Biology at Harvard University. Christianson has served with Prof. Anna Pyle as Co-Editor-in-Chief of Methods in Enzymology since 2015.Dr. Karen N. Allen works at the Department of Chemistry of the Boston University, the Metcalf Center for Science and Engineering Subashchandrabose Chinnathambi is Additional Professor at the Department of Neurochemistry, National Institute of Mental Health and Neurosciences Hospital Bangalore, Karnataka, India. His scientific interests include physiopathology of neurodegenerative disorders, Tau Cytoskeleton, Tau-GPCR, purinergic and chemokine receptors, Tau stem cells, animal models, neuropharmacology, therapeutic approaches targeting Tau oligomers, and biomarkers for neurodegeneration. He serves on the editorial board for various international cell biology journals and is also a regular invited speaker at a number of meetings and workshops. Dr. Chinnathambi has more than 16 years of research experience in the area of neuroscience and Tau-related research in Alzheimer’s Disease.

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• 1. Interaction of HDAC6 ZnF UBP with Tau affects its stability by NMR and Simulation studiesSubashchandrabose Chinnathambi2. Protocols for In Vitro Analysis of Liquid-Liquid Phase Separation of ProteinsTimir Tripathi and Niharika Naga3. Histone deacetylases in NSChandrima Das4. Histone Deacetylase 6 ZnF UBP domain enhances podosome formation in neuronal cells studied by high-resolution confocal microscopySubashchandrabose Chinnathambi5. Methodological approach to Investigate Peroxiredoxin 1 Deacetylation by Histone Deacetylase 6Aparna Banerjee Dixit6. Critical structural features of HDAC11 inhibitorsShovanlal Gayen, Indrasis Dasgupta and Srijoni Sinha7. Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and NeurodegenerationMarco Prinz8. Elucidation of Site-Specific Ubiquitination on Chaperones in Response to Mutant HuntingtinPrasad Kasthuri, Ayush Nigam, Prasun Kumar Bhunia and Trayambak Basak9. Protein acetylation dynamics (histone and non-histone) and role protein deacetylases in diseaseDevyani Haldar10. Epigenetic Clues: Predicting Maternal Depression Through DNA MethylationKuppan Gokulakrishnan11. A short guide on in vivo transfection of flag-HDAC4 in dentate gyrus for study of adult neurogenesis in brain traumaRajaneesh Kumar Gupta12. Decoding the Acetylation Journey from Neural Crest to MelanocyteVivek T. Natarajan13. Histone deacetylase inhibition mitigates cognitive deficits and astrocyte dysfunction induced by amyloid-β (Aβ) oligomersFlávia Carvalho Alcantara Gomes14. Simvastatin Restores HDAC1/2 Activity and Improves Behavioral Deficits in Angelman Syndrome Model MouseNihar Ranjan Jana15. Methodology and Application of ChiP in studying translational dysregulation neurological disordersSumana Chakravarty16. Insights into the epigenetic mechanisms involving histone lysine methylation and demethylation in ischemia induced damage and repair has therapeutic implicationAnant Bahadur Patel17. TBDSamir Patra18. TBDSushabhan Sadhukhan19. Methodological Frameworks to Probe Histone Acetylation–Driven Circuit Plasticity in SYNGAP1–Associated Neurodevelopmental DisordersTapas K. Kundu

After completing studies for the A.B., A.M., and Ph.D. degrees in chemistry at Harvard University, David W. Christianson joined the faculty of the University of Pennsylvania, where he is currently the Roy and Diana Vagelos Professor in Chemistry and Chemical Biology. At Penn, Christianson’s research focuses on the structural and chemical biology of the zinc-dependent histone deacetylases as well as enzymes of terpene biosynthesis. His research accomplishments have been recognized by several awards, including the Pfizer Award in Enzyme Chemistry and the Repligen Award in Chemistry of Biological Processes from the American Chemical Society, a Guggenheim Fellowship, and the Elizabeth S. and Richard M. Cashin Fellowship from the Radcliffe Institute for Advanced Study at Harvard University. Christianson is also a dedicated classroom teacher, and his accomplishments in this regard have been recognized by the Lindback Award for Distinguished Teaching at Penn and a Rhodes Trust Inspirational Educator Award from Oxford University. Christianson has also held visiting professorships in the Department of Biochemistry at Cambridge University and the Department of Chemistry and Chemical Biology at Harvard University. Christianson has served with Prof. Anna Pyle as Co-Editor-in-Chief of Methods in Enzymology since 2015.Dr. Karen N. Allen works at the Department of Chemistry of the Boston University, the Metcalf Center for Science and Engineering Subashchandrabose Chinnathambi is Additional Professor at the Department of Neurochemistry, National Institute of Mental Health and Neurosciences Hospital Bangalore, Karnataka, India. His scientific interests include physiopathology of neurodegenerative disorders, Tau Cytoskeleton, Tau-GPCR, purinergic and chemokine receptors, Tau stem cells, animal models, neuropharmacology, therapeutic approaches targeting Tau oligomers, and biomarkers for neurodegeneration. He serves on the editorial board for various international cell biology journals and is also a regular invited speaker at a number of meetings and workshops. Dr. Chinnathambi has more than 16 years of research experience in the area of neuroscience and Tau-related research in Alzheimer’s Disease.

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• 1. Interaction of HDAC6 ZnF UBP with Tau affects its stability by NMR and Simulation studiesSubashchandrabose Chinnathambi2. Protocols for In Vitro Analysis of Liquid-Liquid Phase Separation of ProteinsTimir Tripathi and Niharika Naga3. Histone deacetylases in NSChandrima Das4. Histone Deacetylase 6 ZnF UBP domain enhances podosome formation in neuronal cells studied by high-resolution confocal microscopySubashchandrabose Chinnathambi5. Methodological approach to Investigate Peroxiredoxin 1 Deacetylation by Histone Deacetylase 6Aparna Banerjee Dixit6. Critical structural features of HDAC11 inhibitorsShovanlal Gayen, Indrasis Dasgupta and Srijoni Sinha7. Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and NeurodegenerationMarco Prinz8. Elucidation of Site-Specific Ubiquitination on Chaperones in Response to Mutant HuntingtinPrasad Kasthuri, Ayush Nigam, Prasun Kumar Bhunia and Trayambak Basak9. Protein acetylation dynamics (histone and non-histone) and role protein deacetylases in diseaseDevyani Haldar10. Epigenetic Clues: Predicting Maternal Depression Through DNA MethylationKuppan Gokulakrishnan11. A short guide on in vivo transfection of flag-HDAC4 in dentate gyrus for study of adult neurogenesis in brain traumaRajaneesh Kumar Gupta12. Decoding the Acetylation Journey from Neural Crest to MelanocyteVivek T. Natarajan13. Histone deacetylase inhibition mitigates cognitive deficits and astrocyte dysfunction induced by amyloid-β (Aβ) oligomersFlávia Carvalho Alcantara Gomes14. Simvastatin Restores HDAC1/2 Activity and Improves Behavioral Deficits in Angelman Syndrome Model MouseNihar Ranjan Jana15. Methodology and Application of ChiP in studying translational dysregulation neurological disordersSumana Chakravarty16. Insights into the epigenetic mechanisms involving histone lysine methylation and demethylation in ischemia induced damage and repair has therapeutic implicationAnant Bahadur Patel17. TBDSamir Patra18. TBDSushabhan Sadhukhan19. Methodological Frameworks to Probe Histone Acetylation–Driven Circuit Plasticity in SYNGAP1–Associated Neurodevelopmental DisordersTapas K. Kundu