Neuroinflammation and Biomarker Discovery

From Mechanisms to Clinical Application

Häftad, Engelska, 2027

1 970 kr

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Beskrivning

Neuroinflammation and Biomarker Discovery: From Mechanisms to Clinical Application offers a detailed exploration of the molecular and cellular processes underlying neuroinflammatory conditions. This essential reference addresses the urgent need for advanced biomarkers that can facilitate early diagnosis, monitor disease progression, and guide personalized treatments in neurodegenerative and autoimmune disorders such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. The book synthesizes current knowledge on neuroimmune interactions, glial cell activation, blood-brain barrier integrity, and innate immune signaling pathways, providing a comprehensive framework for understanding neuroinflammatory mechanisms. It also covers state-of-the-art platforms for biomarker discovery, including transcriptomics, proteomics, lipidomics, epigenomics, extracellular vesicles, and neuroimaging techniques, emphasizing their translational potential. The inclusion of disease-specific biomarker landscapes enhances its relevance for clinicians and researchers working in diagnostics and drug development. The final sections focus on translational applications, such as clinical trial design, biomarker validation, and the integration of AI-driven multi-omics data for personalized neuroimmunology. This volume is an indispensable resource for neuroscientists, clinicians, graduate students, biotech professionals, and data scientists seeking to advance understanding and innovation in neuroinflammatory research and clinical practice. By bridging basic science and clinical application, it aims to accelerate the development of targeted therapies and diagnostic tools, ultimately improving patient outcomes in neuroinflammatory diseases

Explains neuroinflammatory mechanisms at molecular and cellular levels
Connects research findings to clinical diagnostics and therapeutic strategies
Provides disease-specific biomarker profiles for neurodegenerative and autoimmune disorders
Highlights cutting-edge imaging platforms for biomarker discovery

Produktinformation

Utgivningsdatum:2027-03-01
Mått:152 x 229 x undefined mm
Format:Häftad
Språk:Engelska
Antal sidor:350
Förlag:Elsevier Science
ISBN:9780443485299

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Mer om författaren

Arun Kumar Singh is an Assistant Professor in the Department of Pharmacy at University School of Pharmaceutical Sciences, Rayat Bahra University V.P.O. Sahauran, India. He completed his M.Pharm in Pharmaceutics from Galgotias University, Greater Noida. His research interests include nano-formulation, blockchain, IoT, machine learning, artificial intelligence, big data analytics, cancer biology, and neuroscience. He has contributed to academic books and book chapters and has published review articles in the areas of pharmaceutical sciences and healthcare technology. His work focuses on interdisciplinary approaches integrating pharmaceutical research with emerging digital and computational technologies. Dr. Meenakshi Dhanawat is an Associate Professor at the Amity Institute of Pharmacy, Amity University Haryana, with many years of experience in Pharmaceutical Sciences and Medicinal Chemistry. She completed her Master's degree at NIPER, Mohali, focusing on glycosylamino acids, and earned her Ph.D. from IIT-BHU, Varanasi, investigating CNS drug delivery targeting 5HT1A/2A receptors. Her research encompasses synthetic and heterocyclic chemistry, nanotechnology, drug delivery systems, prodrug design, complexation, polymer chemistry, and herbal drug extraction. Dr. Dhanawat has received notable international recognition, including a travel grant from the AAPS Drug Delivery and Development section for the 2010 National Biotechnology Conference in California, and international travel grants from DBT and DST, Government of India, for conferences in California and Munich. Her distinguished honors include the Rajiv Gandhi National Fellowship, affirming her sustained contributions to pharmaceutical research and academic excellence.

Innehållsförteckning

SECTION I: MOLECULAR AND CELLULAR FRAMEWORK OF NEUROINFLAMMATION1. The Neuroimmune Axis: Cellular Interfaces and Bidirectional Signaling2. Microglial Activation States: From Homeostasis to Neurotoxicity3. Astrocyte and Oligodendrocyte Contribution to Neuroinflammation4. Pattern Recognition Receptors and CNS Innate Immunity5. Molecular Triggers: DAMPs, PAMPs, and the Inflammasome Complex6. Blood-Brain Barrier Breakdown and Immune Cell TraffickingSECTION II: SIGNALING NETWORKS IN NEUROINFLAMMATORY PATHWAYS7. NF-κB and MAPK Pathways: Master Regulators of Inflammatory Transcription8. JAK/STAT Signaling and Interferon Regulatory Networks in the CNS9. Redox Signaling, ROS Generation, and Mitochondrial Dysfunction10. Autophagy, Ubiquitin-Proteasome System, and Immune RegulationSECTION III: ADVANCED PLATFORMS FOR BIOMARKER DISCOVERY11. Transcriptomic Approaches: Bulk RNA-Seq and Single-Cell Resolution12. Proteomics and Phosphoproteomics in Neuroinflammation13. Lipidomics and Metabolomics of Inflammatory Brain States14. Epigenomic Biomarkers: DNA Methylation, Histone Modifications, and miRNAs15. Extracellular Vesicles and Exosomal Biomarkers in Neuroinflammatory Diseases16. Imaging Biomarkers: PET, MRI, and Molecular NeuroimagingSECTION IV: DISEASE-SPECIFIC BIOMARKER LANDSCAPES17. Neuroinflammation in Alzheimer's Disease: Aβ, Tau, and Microglial Dysfunction18. Biomarkers of Neuroinflammation in Parkinson’s Disease and Lewy Body Disorders19. Multiple Sclerosis and Autoimmune Neuroinflammation20. Stroke, Traumatic Brain Injury, and Post-Injury Neuroinflammation21. Vascular Ageing and its Impact on Brain Health22. Epstein–Barr Virus (EBV) and Multiple Sclerosis23. Herpes Simplex Virus (HSV) and Alzheimer's DiseaseSECTION V: TRANSLATIONAL APPLICATIONS AND FUTURE DIRECTIONS24. Biomarkers in Clinical Trials: Stratification, Monitoring, and Endpoints25. Toward Personalized Neuroimmunology: AI-Driven Integration of Multi-Omics Data