Ulf Dieckmann is Project Coordinator of the Adaptive Dynamics Network at the International Institute for Applied Systems Analysis (IIASA) in Laxenburg, Austria. He is coeditor of The Geometry of Ecological Interactions. J. (Hans) A. J. Metz is Professor of Mathematical Biology at the Institute of Evolutionary and Ecological Sciences at the University of Leiden, and Project Leader of the Adaptive Dynamics Network at IIASA. He is coeditor of The Geometry of Ecological Interactions. Maurice W. Sabelis is at the Institute for Biodiversity and Ecosystem Dynamics at the University of Amsterdam. Karl Sigmund is Professor at the Institute for Mathematics at the University of Vienna and also a Research Associate with the Adaptive Dynamics Network at IIASA. He is coauthor of Evolutionary Games and Population Dynamics.

'… anyone with an interest in evolutionary dynamics will find several chapters that they wish to read (or ought to read).' TRENDS in Ecology and Evolution

• 1. Introduction Karl Sigmund, Maurice W. Sabelis, Ulf Dieckmann and J. A. J. Metz; Part I. Setting the Stage: 2. Alternative transmission modes and the evolution of virulence Paul W. Ewald and Guilio De Leo; 3. Wildlife perspectives on the evolution of virulence Guilio De Leo, Andy Dobson and Andy Goodman; 4. Adaptive dynamics of pathogen-host interactions Ulf Dieckmann; 5. Dilemmas in virulence management Minus van Baalen; Part II. Host Population Structure: 6. Variation in susceptibility: lessons from an insect virus Greg Dwyer, Jonathan Dushoff, Joseph S. Elkinton, John P. Burand and Simon A. Levin; 7. Contact networks and the evolution of virulence Minus van Baalen; 8. Virulence on the edge: a source-sink perspective Robert D. Holt and Michael E. Hochberg; Part III. Within-Host Interactions: 9. Super- and coinfection: the two extremes Martin Nowak and Karl Sigmund; 10. Super- and coinfection: filling the range Frederick Adler and Julio Mosquero Losada; 11. Multiple infection and its consequences for virulence management Sylvain Gandon and Yannis Michalakis; 12. Kin selection models as evolutionary explanations of malaria Andrew F. Read, Margaret J. Mackinnon, M. Ali Anwar and Louise H. Taylor; Part IV. Pathogen-Host Coevolution: 13. Coevolution of virus and host cell death signals David C. Krakauer; 14. Biogeographical perspectives on arms races Michael E. Hochberg and Robert D. Holt; 15. Major histocompatability complex: polymorphism from coevolution Joost B. Beltman, José A. M. Borghans and Rob J. de Boer; 16. Virulence management and disease resistance in diploid hosts Viggo Andreasen; 17. Coevolution in gene-for-gene systems Akira Sasaki; 18. Implications of sexual selection for virulence management Claus Wedekind; 19. Molecular phylogenies and virulence evolution Bruce Rannala; Part V. Multilevel Selection: 20. Weakened from within: intragenomic conflict and virulence Rolf F. Hoekstra and Alfons J. M. Debets; 21. Ecology and evolution of chestnut blight fungus Douglas R. Taylor; 22. Evolution of exploitation and defense in tritrophic interactions Maurice W. Sabelis, Minus van Baalen, Bas Pels, Martijn Egas and Arne Janssen; Part VI. Vaccines and Drugs: 23. Managing antibiotic resistance Sebastian Bonhoeffer; 24. Evolution of vaccine-resistant strains of infectious agents Angela McLean; 25. Pathogen evolution: the case of malaria Sunetra Gupta; 26. Vaccination and serotype replacement Marc Lipsitch; Part VII. Perspectives for Virulence Management: 27. Taking stock: relating theory to experiment Maurice W. Sabelis and Johan A. J. Metz; 28. Virulence management in humans Paul W. Ewald; 29. Virulence management in wildlife populations Guilio De Leo and Andy Dobson; 30. Virulence management in veterinary epidemiology Mart C. M. de Jong and Luc L. G. Janss; 31. Virulence management in plant-pathogen interactions Andrew M. Jarosz; 32. Management of virulence in biocontrol agents Sam L. Elliot, Maurice W. Sabelis and Frederick R. Adler; 33. Epilogue Ulf Dieckmann, Karl Sigmund, Maurice W. Sabelis and Johan A. J. Metz.

Ulf Dieckmann is Project Coordinator of the Adaptive Dynamics Network at the International Institute for Applied Systems Analysis (IIASA) in Laxenburg, Austria. He is coeditor of The Geometry of Ecological Interactions. J. (Hans) A. J. Metz is Professor of Mathematical Biology at the Institute of Evolutionary and Ecological Sciences at the University of Leiden, and Project Leader of the Adaptive Dynamics Network at IIASA. He is coeditor of The Geometry of Ecological Interactions. Maurice W. Sabelis is at the Institute for Biodiversity and Ecosystem Dynamics at the University of Amsterdam. Karl Sigmund is Professor at the Institute for Mathematics at the University of Vienna and also a Research Associate with the Adaptive Dynamics Network at IIASA. He is coauthor of Evolutionary Games and Population Dynamics.

'… anyone with an interest in evolutionary dynamics will find several chapters that they wish to read (or ought to read).' TRENDS in Ecology and Evolution

• 1. Introduction Karl Sigmund, Maurice W. Sabelis, Ulf Dieckmann and J. A. J. Metz; Part I. Setting the Stage: 2. Alternative transmission modes and the evolution of virulence Paul W. Ewald and Guilio De Leo; 3. Wildlife perspectives on the evolution of virulence Guilio De Leo, Andy Dobson and Andy Goodman; 4. Adaptive dynamics of pathogen-host interactions Ulf Dieckmann; 5. Dilemmas in virulence management Minus van Baalen; Part II. Host Population Structure: 6. Variation in susceptibility: lessons from an insect virus Greg Dwyer, Jonathan Dushoff, Joseph S. Elkinton, John P. Burand and Simon A. Levin; 7. Contact networks and the evolution of virulence Minus van Baalen; 8. Virulence on the edge: a source-sink perspective Robert D. Holt and Michael E. Hochberg; Part III. Within-Host Interactions: 9. Super- and coinfection: the two extremes Martin Nowak and Karl Sigmund; 10. Super- and coinfection: filling the range Frederick Adler and Julio Mosquero Losada; 11. Multiple infection and its consequences for virulence management Sylvain Gandon and Yannis Michalakis; 12. Kin selection models as evolutionary explanations of malaria Andrew F. Read, Margaret J. Mackinnon, M. Ali Anwar and Louise H. Taylor; Part IV. Pathogen-Host Coevolution: 13. Coevolution of virus and host cell death signals David C. Krakauer; 14. Biogeographical perspectives on arms races Michael E. Hochberg and Robert D. Holt; 15. Major histocompatability complex: polymorphism from coevolution Joost B. Beltman, José A. M. Borghans and Rob J. de Boer; 16. Virulence management and disease resistance in diploid hosts Viggo Andreasen; 17. Coevolution in gene-for-gene systems Akira Sasaki; 18. Implications of sexual selection for virulence management Claus Wedekind; 19. Molecular phylogenies and virulence evolution Bruce Rannala; Part V. Multilevel Selection: 20. Weakened from within: intragenomic conflict and virulence Rolf F. Hoekstra and Alfons J. M. Debets; 21. Ecology and evolution of chestnut blight fungus Douglas R. Taylor; 22. Evolution of exploitation and defense in tritrophic interactions Maurice W. Sabelis, Minus van Baalen, Bas Pels, Martijn Egas and Arne Janssen; Part VI. Vaccines and Drugs: 23. Managing antibiotic resistance Sebastian Bonhoeffer; 24. Evolution of vaccine-resistant strains of infectious agents Angela McLean; 25. Pathogen evolution: the case of malaria Sunetra Gupta; 26. Vaccination and serotype replacement Marc Lipsitch; Part VII. Perspectives for Virulence Management: 27. Taking stock: relating theory to experiment Maurice W. Sabelis and Johan A. J. Metz; 28. Virulence management in humans Paul W. Ewald; 29. Virulence management in wildlife populations Guilio De Leo and Andy Dobson; 30. Virulence management in veterinary epidemiology Mart C. M. de Jong and Luc L. G. Janss; 31. Virulence management in plant-pathogen interactions Andrew M. Jarosz; 32. Management of virulence in biocontrol agents Sam L. Elliot, Maurice W. Sabelis and Frederick R. Adler; 33. Epilogue Ulf Dieckmann, Karl Sigmund, Maurice W. Sabelis and Johan A. J. Metz.

Ulf Dieckmann is Project Coordinator of the Adaptive Dynamics Network at the International Institute for Applied Systems Analysis (IIASA) in Laxenburg, Austria. He is coeditor of The Geometry of Ecological Interactions. J. (Hans) A. J. Metz is Professor of Mathematical Biology at the Institute of Evolutionary and Ecological Sciences at the University of Leiden, and Project Leader of the Adaptive Dynamics Network at IIASA. He is coeditor of The Geometry of Ecological Interactions. Maurice W. Sabelis is at the Institute for Biodiversity and Ecosystem Dynamics at the University of Amsterdam. Karl Sigmund is Professor at the Institute for Mathematics at the University of Vienna and also a Research Associate with the Adaptive Dynamics Network at IIASA. He is coauthor of Evolutionary Games and Population Dynamics.

'… anyone with an interest in evolutionary dynamics will find several chapters that they wish to read (or ought to read).' TRENDS in Ecology and Evolution

• 1. Introduction Karl Sigmund, Maurice W. Sabelis, Ulf Dieckmann and J. A. J. Metz; Part I. Setting the Stage: 2. Alternative transmission modes and the evolution of virulence Paul W. Ewald and Guilio De Leo; 3. Wildlife perspectives on the evolution of virulence Guilio De Leo, Andy Dobson and Andy Goodman; 4. Adaptive dynamics of pathogen-host interactions Ulf Dieckmann; 5. Dilemmas in virulence management Minus van Baalen; Part II. Host Population Structure: 6. Variation in susceptibility: lessons from an insect virus Greg Dwyer, Jonathan Dushoff, Joseph S. Elkinton, John P. Burand and Simon A. Levin; 7. Contact networks and the evolution of virulence Minus van Baalen; 8. Virulence on the edge: a source-sink perspective Robert D. Holt and Michael E. Hochberg; Part III. Within-Host Interactions: 9. Super- and coinfection: the two extremes Martin Nowak and Karl Sigmund; 10. Super- and coinfection: filling the range Frederick Adler and Julio Mosquero Losada; 11. Multiple infection and its consequences for virulence management Sylvain Gandon and Yannis Michalakis; 12. Kin selection models as evolutionary explanations of malaria Andrew F. Read, Margaret J. Mackinnon, M. Ali Anwar and Louise H. Taylor; Part IV. Pathogen-Host Coevolution: 13. Coevolution of virus and host cell death signals David C. Krakauer; 14. Biogeographical perspectives on arms races Michael E. Hochberg and Robert D. Holt; 15. Major histocompatability complex: polymorphism from coevolution Joost B. Beltman, José A. M. Borghans and Rob J. de Boer; 16. Virulence management and disease resistance in diploid hosts Viggo Andreasen; 17. Coevolution in gene-for-gene systems Akira Sasaki; 18. Implications of sexual selection for virulence management Claus Wedekind; 19. Molecular phylogenies and virulence evolution Bruce Rannala; Part V. Multilevel Selection: 20. Weakened from within: intragenomic conflict and virulence Rolf F. Hoekstra and Alfons J. M. Debets; 21. Ecology and evolution of chestnut blight fungus Douglas R. Taylor; 22. Evolution of exploitation and defense in tritrophic interactions Maurice W. Sabelis, Minus van Baalen, Bas Pels, Martijn Egas and Arne Janssen; Part VI. Vaccines and Drugs: 23. Managing antibiotic resistance Sebastian Bonhoeffer; 24. Evolution of vaccine-resistant strains of infectious agents Angela McLean; 25. Pathogen evolution: the case of malaria Sunetra Gupta; 26. Vaccination and serotype replacement Marc Lipsitch; Part VII. Perspectives for Virulence Management: 27. Taking stock: relating theory to experiment Maurice W. Sabelis and Johan A. J. Metz; 28. Virulence management in humans Paul W. Ewald; 29. Virulence management in wildlife populations Guilio De Leo and Andy Dobson; 30. Virulence management in veterinary epidemiology Mart C. M. de Jong and Luc L. G. Janss; 31. Virulence management in plant-pathogen interactions Andrew M. Jarosz; 32. Management of virulence in biocontrol agents Sam L. Elliot, Maurice W. Sabelis and Frederick R. Adler; 33. Epilogue Ulf Dieckmann, Karl Sigmund, Maurice W. Sabelis and Johan A. J. Metz.