Brian K. Nunnally and Ira S. Krull

• Foreword, Preface, Contributors, 1. Taking Aim at the Transmissible Spongiform Encephalopathies Infectious Agents, 2. Prions, the Protein Hypothesis, and Scientific Revolutions, 3. A Simulation Model for Evaluating the Potential for Spread of Bovine Spongiform Encephalopathy in Animals or to People, 4. Actions to Prevent Bovine Spongiform Encephalopathy from Entering the United States, 5. Overview of Transmissible Spongiform Encephalopathy in Cervids in the United States, 6. Bioassays for Prions, 7. Cyclic Amplification of Scrapie Prion Protein: Implications for Diagnosis, 8. The Enfer Transmissible Spongiform Encephalopathies Assay: Chemiluminescent ELISA of Prion Proteins, 9. Sensitive Detection of Prion Proteins by Immunoassay: CEA/Bio-Rad Test, 10. The Diagnosis of Transmissible Spongiform Encephalopathies Using Differential Extraction and DELFIA, 11. In Vivo Diagnosis of Prion Diseases, 12. Diagnosis of Prion Diseases by Multispectral Techniques, 13. Detection of the Prion Protein in Blood Using a Fluorescence Immunoassay, 14. Prion Detection and Application to the Safety of Biological Products, Index