Protein-Solvent Interactions

". . .a broad and much-needed survey of biophysical aspects of the interplay between proteins and their solvent. . . . . .uniformly well-written. . .of value to anyone with an active interest in the physical chemistry of proteins. "---FEBS Letters

• The new paradigm for protein research; solvent interactions with proteins as revealed by X-ray crystallographic studies; protein hydration and glass transition behavior; dielectric studies of protein hydration; protein dynamics - hydration, temperature and solvent viscosity effects as revealed by Rayleigh Scattering of Mossbauer Radiation (RSMR); proteins in essentially non-aqueous environments; solvent viscosity effects on protein dynamics - updating the concepts; effect of solvent on protein internal dynamics - the kinetics of ligand binding to myoglobin; solvent effects on protein stability and protein association; thermodynamic mechanisms for enthalpy-entropy compensation; preferential interactions of water and cosolvents with proteins; thermodynamic nonideality and protein solvation; molecular basis for protein separations.