Modeling Inhibitors of Matrix Metalloproteinases

Matrix metalloproteinases (MMPs) have been established as promising biomolecular targets for novel drug design and discovery against numerous major disease conditions including various cancers, cardiovascular, neurodegenerative, inflammatory diseases, and more. This book covers various modern molecular modeling methodologies particularly related to MMP inhibitors. Included in the text are descriptions of ligand-based drug designing and structure-based drug designing modeling strategies for designing potential and target specific or selective MMPIs. This book will benefit those who are looking for an in-depth text on the design and discovery processes of novel and selective MMPIs.FeaturesDescribes modeling strategies applied to MMPsElaborates on the designing strategies of MMPs specificallyIncludes in-depth analyses of related case studiesActs as a guide for medicinal chemists, not only from pharmaceutical industries, but also from academiaCovers various modern molecular modeling methodologies, particularly related to MMPIs