Prof. Ashok Kumar is a chair professor of bioengineering at the Department of Biological Sciences and Bioengineering, Indian Institute of Technology (IIT), Kanpur, India. He received his Ph.D. in Biotechnology from IIT Roorkee. He conducted his postdoctoral research at Nagoya University, Japan, and Lund University, Sweden. He has published more than 230 research papers, edited five books, has many patents granted/filed, and has transferred technologies to industry. His areas of research interest include biomaterials, tissue engineering, regenerative medicine, bioprocess engineering, and environmental biotechnology. Prof. Kumar has been conducting active national and international research collaborations and has been recognized with various awards and appreciations for his outstanding research contributions.Dr. Sneha Singh is an assistant professor in the Department of Bioengineering and Biotechnology at Birla Institute of Technology, Mesra, Ranchi, India (BIT Mesra). She received her Ph.D. in the domain of nanobiotechnology from BIT. She has published many peer-reviewed research papers, book chapters, edited books, and patents to her credit. Her research interests span nanobiotechnology, biomaterials and tissue engineering, phytomedicines, antimicrobials and regenerative medicine specializing in nanomaterials, phytobioactives, and smart biomaterials for biomedical applications while conducting active research collaborations with eminent institutions nationally and internationally.Dr. Prerna Singh is currently a postdoctoral fellow in the Department of Biological Sciences and Bioengineering, IIT Kanpur, India. She received her Ph.D. in biotechnology from Banaras Hindu University, India, in 2017. Her research areas include biomaterials, tissue engineering, regenerative medicine, stem cell research, and phytomedicine. She has significant peerreviewed research articles, granted patent, book chapters and edited issues in journals among her scientific accomplishments. She is presently working in the area of biocompatible scaffolds for bone and soft tissue engineering. She has been involved in international and national collaborative research work with Aalto University, Finland; IIT Delhi; SKUAST, Kashmir; BIT Mesra, and BHU.

• I Introduction: The Synthesis and Characterization of Biomaterials for Bone Regeneration 1 Cellular and Molecular Interplay in Bone Homeostasis and Healing; 2 Choice and Selection of Biomaterials for Bone Repair; 3 Synthetic Bone Analogue Materials and Design for Skeletal Tissue Healing; 4 Integrating 3D Printing and Electrospinning to Fabricate Scaffolds for Bone Regeneration; 5 The 3D/4D Printing of Polymeric Scaffolds for Bone Tissue Engineering; 6 Recent Advances in Biodegradable Implants in Bone Tissue Engineering; 7 Recent Advances in Characterization Techniques for Bone Substitutes; II Application of Nanotechnology and Phytomedicines for Bone Repair and Regeneration 8 Spatially Controlled Delivery of Bioactive Cues for Bone Tissue Engineering: From Nano to Macro Scale; 9 Nanotechnology Advancements for Improved Bone Metabolism, Regeneration and Treatment of Bone Diseases; 10 Osteoblast and Osteoclast Crosstalk during Osteo-Homeostasis and Biotherapeutic Interventions; 11 Modulatory Effects of Phytobioactives in Bone Metabolism and Regeneration; III Advancement and Application of Tissue Engineering toward Orthopedic Concerns 12 Unraveling Translational Research on Ultra-High Molecular Weight Polyethylene in Total Hip Joint Arthroplasty: A Lab-to-Industry-Scale Pilot Study; 13 The Physiology of Bone Homeostasis to Aid Experimental Therapeutics in Disease Conditions; 14 Biomimetic Bone Models in Advancing Bone Regeneration and Repair; 15 Biomaterials and Their Carriers for Managing Bone Disorders; 16 Next-Generation Theranostic Tools for Bone Repair and Skeletal Metabolism with Exosomes; 17 Clinically Relevant Bone Diseases and Bone Fracture Animal Models; 18 Advanced Biomaterial-Based Strategies for Intervertebral Disc Repair and Regeneration; 19 Osteoarthritis Pain and Current Therapeutic Strategies

Prof. Ashok Kumar is a chair professor of bioengineering at the Department of Biological Sciences and Bioengineering, Indian Institute of Technology (IIT), Kanpur, India. He received his Ph.D. in Biotechnology from IIT Roorkee. He conducted his postdoctoral research at Nagoya University, Japan, and Lund University, Sweden. He has published more than 230 research papers, edited five books, has many patents granted/filed, and has transferred technologies to industry. His areas of research interest include biomaterials, tissue engineering, regenerative medicine, bioprocess engineering, and environmental biotechnology. Prof. Kumar has been conducting active national and international research collaborations and has been recognized with various awards and appreciations for his outstanding research contributions.Dr. Sneha Singh is an assistant professor in the Department of Bioengineering and Biotechnology at Birla Institute of Technology, Mesra, Ranchi, India (BIT Mesra). She received her Ph.D. in the domain of nanobiotechnology from BIT. She has published many peer-reviewed research papers, book chapters, edited books, and patents to her credit. Her research interests span nanobiotechnology, biomaterials and tissue engineering, phytomedicines, antimicrobials and regenerative medicine specializing in nanomaterials, phytobioactives, and smart biomaterials for biomedical applications while conducting active research collaborations with eminent institutions nationally and internationally.Dr. Prerna Singh is currently a postdoctoral fellow in the Department of Biological Sciences and Bioengineering, IIT Kanpur, India. She received her Ph.D. in biotechnology from Banaras Hindu University, India, in 2017. Her research areas include biomaterials, tissue engineering, regenerative medicine, stem cell research, and phytomedicine. She has significant peerreviewed research articles, granted patent, book chapters and edited issues in journals among her scientific accomplishments. She is presently working in the area of biocompatible scaffolds for bone and soft tissue engineering. She has been involved in international and national collaborative research work with Aalto University, Finland; IIT Delhi; SKUAST, Kashmir; BIT Mesra, and BHU.

• I Introduction: The Synthesis and Characterization of Biomaterials for Bone Regeneration 1 Cellular and Molecular Interplay in Bone Homeostasis and Healing; 2 Choice and Selection of Biomaterials for Bone Repair; 3 Synthetic Bone Analogue Materials and Design for Skeletal Tissue Healing; 4 Integrating 3D Printing and Electrospinning to Fabricate Scaffolds for Bone Regeneration; 5 The 3D/4D Printing of Polymeric Scaffolds for Bone Tissue Engineering; 6 Recent Advances in Biodegradable Implants in Bone Tissue Engineering; 7 Recent Advances in Characterization Techniques for Bone Substitutes; II Application of Nanotechnology and Phytomedicines for Bone Repair and Regeneration 8 Spatially Controlled Delivery of Bioactive Cues for Bone Tissue Engineering: From Nano to Macro Scale; 9 Nanotechnology Advancements for Improved Bone Metabolism, Regeneration and Treatment of Bone Diseases; 10 Osteoblast and Osteoclast Crosstalk during Osteo-Homeostasis and Biotherapeutic Interventions; 11 Modulatory Effects of Phytobioactives in Bone Metabolism and Regeneration; III Advancement and Application of Tissue Engineering toward Orthopedic Concerns 12 Unraveling Translational Research on Ultra-High Molecular Weight Polyethylene in Total Hip Joint Arthroplasty: A Lab-to-Industry-Scale Pilot Study; 13 The Physiology of Bone Homeostasis to Aid Experimental Therapeutics in Disease Conditions; 14 Biomimetic Bone Models in Advancing Bone Regeneration and Repair; 15 Biomaterials and Their Carriers for Managing Bone Disorders; 16 Next-Generation Theranostic Tools for Bone Repair and Skeletal Metabolism with Exosomes; 17 Clinically Relevant Bone Diseases and Bone Fracture Animal Models; 18 Advanced Biomaterial-Based Strategies for Intervertebral Disc Repair and Regeneration; 19 Osteoarthritis Pain and Current Therapeutic Strategies

Prof. Ashok Kumar is a chair professor of bioengineering at the Department of Biological Sciences and Bioengineering, Indian Institute of Technology (IIT), Kanpur, India. He received his Ph.D. in Biotechnology from IIT Roorkee. He conducted his postdoctoral research at Nagoya University, Japan, and Lund University, Sweden. He has published more than 230 research papers, edited five books, has many patents granted/filed, and has transferred technologies to industry. His areas of research interest include biomaterials, tissue engineering, regenerative medicine, bioprocess engineering, and environmental biotechnology. Prof. Kumar has been conducting active national and international research collaborations and has been recognized with various awards and appreciations for his outstanding research contributions.Dr. Sneha Singh is an assistant professor in the Department of Bioengineering and Biotechnology at Birla Institute of Technology, Mesra, Ranchi, India (BIT Mesra). She received her Ph.D. in the domain of nanobiotechnology from BIT. She has published many peer-reviewed research papers, book chapters, edited books, and patents to her credit. Her research interests span nanobiotechnology, biomaterials and tissue engineering, phytomedicines, antimicrobials and regenerative medicine specializing in nanomaterials, phytobioactives, and smart biomaterials for biomedical applications while conducting active research collaborations with eminent institutions nationally and internationally.Dr. Prerna Singh is currently a postdoctoral fellow in the Department of Biological Sciences and Bioengineering, IIT Kanpur, India. She received her Ph.D. in biotechnology from Banaras Hindu University, India, in 2017. Her research areas include biomaterials, tissue engineering, regenerative medicine, stem cell research, and phytomedicine. She has significant peerreviewed research articles, granted patent, book chapters and edited issues in journals among her scientific accomplishments. She is presently working in the area of biocompatible scaffolds for bone and soft tissue engineering. She has been involved in international and national collaborative research work with Aalto University, Finland; IIT Delhi; SKUAST, Kashmir; BIT Mesra, and BHU.

• I Introduction: The Synthesis and Characterization of Biomaterials for Bone Regeneration 1 Cellular and Molecular Interplay in Bone Homeostasis and Healing; 2 Choice and Selection of Biomaterials for Bone Repair; 3 Synthetic Bone Analogue Materials and Design for Skeletal Tissue Healing; 4 Integrating 3D Printing and Electrospinning to Fabricate Scaffolds for Bone Regeneration; 5 The 3D/4D Printing of Polymeric Scaffolds for Bone Tissue Engineering; 6 Recent Advances in Biodegradable Implants in Bone Tissue Engineering; 7 Recent Advances in Characterization Techniques for Bone Substitutes; II Application of Nanotechnology and Phytomedicines for Bone Repair and Regeneration 8 Spatially Controlled Delivery of Bioactive Cues for Bone Tissue Engineering: From Nano to Macro Scale; 9 Nanotechnology Advancements for Improved Bone Metabolism, Regeneration and Treatment of Bone Diseases; 10 Osteoblast and Osteoclast Crosstalk during Osteo-Homeostasis and Biotherapeutic Interventions; 11 Modulatory Effects of Phytobioactives in Bone Metabolism and Regeneration; III Advancement and Application of Tissue Engineering toward Orthopedic Concerns 12 Unraveling Translational Research on Ultra-High Molecular Weight Polyethylene in Total Hip Joint Arthroplasty: A Lab-to-Industry-Scale Pilot Study; 13 The Physiology of Bone Homeostasis to Aid Experimental Therapeutics in Disease Conditions; 14 Biomimetic Bone Models in Advancing Bone Regeneration and Repair; 15 Biomaterials and Their Carriers for Managing Bone Disorders; 16 Next-Generation Theranostic Tools for Bone Repair and Skeletal Metabolism with Exosomes; 17 Clinically Relevant Bone Diseases and Bone Fracture Animal Models; 18 Advanced Biomaterial-Based Strategies for Intervertebral Disc Repair and Regeneration; 19 Osteoarthritis Pain and Current Therapeutic Strategies