This handbook provides comprehensive coverage of the role of proteases and the associated biochemical pathways in cancer development and metastasis. Proteases make up about 2% of the human genome and play a critical role in the tumor microenvironment. Handbook of Proteases in Cancer: Cellular and Molecular Aspects introduces the major classes of proteases and the signal transduction mechanisms associated with cancer initiation and progression. It discusses the role of inflammation and immune responses in proteases-induced cancer. The book covers cancer-induced gene expression and apoptotic and necrotic pathways in cancer. This is useful for researchers and professionals in cancer research, biochemistry, and physiology. Key Features• Provides insights on the roles of proteases and anti-proteases in the tumor microenvironment.• Covers various cancer-induced apoptotic and necrotic pathways.• Discusses the mechanisms by which proteases induce an increase in inflammation, immuneresponse, and gene expression.• Covers the function of protease-activated receptors in cancer.• Reviews the different gene expression pathways and the ways they become erratic duringprotease-induced cancer.
