Chemistry of Solid-Phase Extraction for Use in Forensic Toxicology

Inbunden, Engelska, 2026

2 013 kr

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Beskrivning

Modern solid-phase extraction (SPE) chemistry dates back to 1986 when three researchers began developing applications for high-performance liquid chromatography (HPLC) analysis. It was found that when C18 was added directly to urine, steroids could be extracted. From this start, SPE was further developed when various bonded silica gels were packed into syringe barrels, expanding the number of drugs that could be extracted by this technique. Since then, significant advancements have been made in the field. This book provides detailed background information on the chemistry and biological action of various drugs, the chemistry of silica-gel sorbents along with newer polymer sorbents and how their properties affect extraction. Here clinical methods are outlined that have been developed for forensic analysis of drugs of abuse performed in the laboratories of United Chemical Technologies, Inc. Step-by-step drug extraction procedures and analysis methods from a variety of matrices such as blood, urine, hair, and other substrates are shown. Instrument analysis conditions for HPLC and gas chromatography (GC), and laboratory equipment employed are described. Drugs covered in this complete how-to-do book cover a wide range of compounds ranging from hypnotics, antidepressants, opiates, analgesics, psychedelics, and steroids. Extensive references are provided.

Produktinformation

Utgivningsdatum:2026-07-01
Mått:148 x 212 x undefined mm
Format:Inbunden
Språk:Engelska
Antal sidor:695
Förlag:Cambridge Scholars Publishing
ISBN:9781036471828

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Mike Telepchak is the CEO/Founder of United Chemical Technologies (UCT), Inc. – an ISO 9001:2015 certified manufacturer of solid phase extraction sorbents, specialty chemicals, chromatographic media, and sample preparation products. Mike earned a BS in Chemistry from Ursinus College in Collegeville, Pennsylvania, USA, and an MBA from the University of Connecticut in Storrs, Connecticut, USA. Since UCT began in 1974, Mike, along with associates, has introduced solid-phase extraction chemistry for use in forensic drug analysis. Now detection and analysis of drugs of abuse is a routine procedure in laboratories. Since then, hundreds of articles have been published in scientific literature. UCT products are sold world-wide.Craig A. Perman holds a Master's degree in Chemistry, and most recently, was a research chemist for 3M Company in St Paul, Minnesota, USA for 25 years before retiring in Colorado. While at 3M, he authored 17 patents in a diversity of areas including supercritical fluid processing for extraction and for preparation of very high strength, low density polymeric foams. Additionally, he was awarded patents for new molecule synthesis for graphic imaging, and devices and methods for solid-phase extraction of drugs and environmental pollutants. Prior to his work at 3M, he received two patents on water purification compositions, and one for silver recovery.