Clinical and Preclinical Models for Maximizing Healthspan

Methods and Protocols

AvPaul C. Guest

Häftad, Engelska, 2021

Del i serien Methods in Molecular Biology

1 202 kr

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Beskrivning

This book presents a series of protocols in multiple disease areas affected by the aging process along with several methods which have shown progress in nutrient- or intervention-based approaches to maximize the healthspan.

Produktinformation

Utgivningsdatum:2021-03-27
Mått:178 x 254 x 26 mm
Vikt:873 g
Format:Häftad
Språk:Engelska
Serie:Methods in Molecular Biology
Antal sidor:451
Förlag:Springer-Verlag New York Inc.
ISBN:9781071604731

Utforska kategorier

Innehållsförteckning

The Impact of New Biomarkers and Drug Targets on Age-Related Disorders.- Vitamin D and Muscle Sarcopenia in Aging.- Quantitative Assays of Plasma Apolipoproteins.- Protocol for the Use of the Ketogenic Diet in Preclinical and Clinical Practice.- An In Vivo/Ex Vivo Study Design to Investigate Effects of Chronic Conditions and Therapeutic Compounds on Adipose Stem Cells in Animal Models.- Model for Studying the Effects of Chronic Metabolic Disease on Endogenous Bone Marrow Stem Cell Populations.- Investigating Alcohol Behavior and Physiology Using Drosophila Melanogaster.- Using Genome-Editing Tools to Develop a Novel In Situ Coincidence Reporter Assay for Screening ATAD3A Transcript Inhibitors.- Visualizing and Evaluating Cancer Cell Growth and Invasion by a Novel 3D Culture System.- Exploiting Plug-and-Play Electrochemical Biosensors to Determine the Role of FGF19 in Sorafenib-Mediated Superoxide and Nitric Oxide Production in Hepatocellular Carcinoma Cells.- Proteomic Analysis of the Anoikis-Resistant Human Breast Cancer Cell Lines.- Real-Time PCR Analysis of Metabolism-Related Genes in a Long-Lived Model of C. Elegans.- Clinical Assessment of the NADome as Biomarkers for Healthy Aging.- 2D Gel Electrophoresis Combined with Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Analysis of Eye Lens to Identify Biomarkers of Age-Related Cataract.- Testing the Effects of Dietary Seafood Consumption on Depressive Symptoms.- Assays for Monitoring the Effects of Nicotinamide Supplementation on Mitochondrial Activity in Saccharomyces Cerevisiae.- Measurement of a Surrogate Biomarker for Arginine Vasopressin Secretion is Association with Physiometric and Molecular Biomarkers of Aging.- Liquid Chromatography Tandem Mass Spectrometry Analysis of Proteins Associated with Age-Related Disorders in Human Pituitary Tissue.- Coenzyme Q10 Assessment and the Establishment of a Neuronal Cell Model of CoQ10 Deficiency.- Analyzing Mitochondrial Function in Brown Adipocytes with a Bioenergetic Analyzer.- Quantitative Analysis of DNA Methylation by Bisulfite Sequencing.- Histomorphometric Analysis of Anti-Aging Properties on Rat Skin.- Integration of qRT-PCR and Immunohistochemical Techniques for mRNA Expression and Localization of m1AChR in the Brain of Aging Rat.- Randomized Study Design to Test Effects of Vitamin D and Omega-3 Fatty Acid Supplementation as Adjuvant Therapy in Colorectal Cancer Patients.- Effect of Vitamin D Supplementation on Muscle Strength, Muscle Function, and Body Composition in Vitamin D-Deficient Middle-Aged Women.- The Association of Food Intake and Physical Activity with Body Composition, Muscle Strength, and Muscle Function in Postmenopausal Women.- Absolute Quantification of Plasma Apolipoproteins for Cardiovascular Disease Risk Prediction.- Multiplex Analysis of Circulating Hormone Levels in Rat Models of Age-Related Diseases.- Proteomic Analysis of Brain Tissue from a Chronic Model of Stress Using a Combined 2D Gel Electrophoresis and Mass Spectrometry Approach.- Proteomic Analysis of Rat Hippocampus for Studies of Cognition and Memory Loss with Aging.- Brain Proteomic Analysis on the Effects of the Antidepressant Fluoxetine.- MK-801 Treatment of Oligodendrocytes as a Cellular Model of Aging.