RNA Vaccines

Methods and Protocols

AvThomas Kramps

Inbunden, Engelska, 2024

Del 2786 i serien Methods in Molecular Biology

2 540 kr

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Beskrivning

This second edition volume expands on the previous edition with discussions of the latest technology and advancements in the development of RNA vaccines and proposed solutions on how to tackle currently unmet medical needs.

Produktinformation

Utgivningsdatum:2024-05-31
Mått:178 x 254 x 28 mm
Vikt:954 g
Format:Inbunden
Språk:Engelska
Serie:Methods in Molecular Biology
Antal sidor:389
Upplaga:2
Förlag:Springer-Verlag New York Inc.
ISBN:9781071637692

Utforska kategorier

Onkologi inom Medicin
Biokemisk teknik inom Naturvetenskap och teknik
Biovetenskap inom Naturvetenskap och teknik

Innehållsförteckning

Introduction to RNA Vaccines Post COVID-19.- Self-Replicating RNA Derived from the Genomes of Positive Strand RNA Viruses.- Negative Strand RNA Virus Vectored Vaccines.- New Generation Self-Replicating RNA Vaccines Derived from Pestivirus Genome.- Trans-Amplifying RNA Vaccines Against Infectious Diseases: A Comparison with Non-Replicating and Self-Amplifying RNA.- Generation and Characterization of In Vitro Transcribed mRNA.- Production and Evaluation of Nucleoside-Modified mRNA Vaccines for Infectious Diseases.- Sequence-Optimized mRNA Vaccines Against Infectious Disease.- Design and Synthesis of Circular RNA Expression Vectors.- Electroporation of mRNA as a Universal Technology Platform to Transfect a Variety of Primary Cells with Antigens and Functional Proteins.- A Basic Method for Formulating mRNA-Lipid Nanoparticle Vaccines in the Lab.- Messenger RNA Lipid-Based Nanoparticles: Optimization of Formulations in the Lab.- Plant Expression of Trans-Encapsidated Chimeric Viral Vaccines with Animal RNA Replicons: An Update.- Producing Plasmid DNA Template for Clinical Grade RNA Vaccine Manufacture.- Regulatory Considerations for Producing mRNA Vaccines for Clinical Trials.- Quality by Digital Design for Developing Platform RNA Vaccine Manufacturing Processes.- Nonclinical Safety Testing of RNA Vaccines.