NMDA Receptors

Methods and Protocols

AvNail Burnashev,Pierre Szepetowski

Inbunden, Engelska, 2024

Del i serien Methods in Molecular Biology

2 311 kr

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Beskrivning

This fully updated volume explores N-Methyl-D-aspartate receptors (NMDARs), and the structure-function relations, principles, and rules that govern how NMDARs operate in brain processing under normal and pathological conditions.

Produktinformation

Utgivningsdatum:2024-05-11
Mått:178 x 254 x 23 mm
Vikt:780 g
Format:Inbunden
Språk:Engelska
Serie:Methods in Molecular Biology
Antal sidor:292
Upplaga:2
Förlag:Springer-Verlag New York Inc.
ISBN:9781071638293

Utforska kategorier

Biovetenskap inom Naturvetenskap och teknik

Innehållsförteckning

Spectrum of NMDA Receptor Variants in Neurodevelopmental Disorders and Epilepsy.- Expression and Purification of Mammalian NMDA Receptor Protein for Functional Characterization.- Analysis of Surface Expression of NMDAR Subunits in Primary Hippocampal Neurons.- Transfection in Primary Cultured Neuronal Cells.- Selective Cell-Surface Expression of Triheteromeric NMDA Receptors.- Generation of Rare Human NMDA Receptor Variants in Mice.- Behavioral Analysis of NMDAR Function in Rodents: Tests of Long-Term Spatial Memory.- Functional Analysis of NMDAR Subunits Components in Post Synaptic Currents of Identified Cells and Synapses in Brain Slices.- Estimating the Ca2+ Block of NMDA Receptors with Single-Channel Electrophysiology.- Estimating the Ca2+ Permeability of NMDA Receptors with Whole-Cell Patch-Clamp Electrophysiology.- Analysis of Functional NMDA Receptors in Astrocytes.- Single-Molecule FRET Analyses of NMDA Receptors.- Behavioral Assays Dissecting NMDA Receptor Function in Zebrafish.- Characterizing Functional Contributions of Specific GluN2 Subunits to Individual Postsynaptic NMDAR Responses Using Biophysical Parameters.- Modeling and Simulation of the NMDA Receptor at Coarse-Grained and Atomistic Levels.- Application of Deep Learning for Studying NMDA Receptors.