Nina Berova is a Research Professor in the Department of Chemistry at Columbia University. She has been a coeditor of the journal Chirality (Wiley) since 1998.Prasad L. Polavarapu is currently a Professor of Chemistry at Vanderbilt University.Koji Nakanishi is one of the world's leading natural products chemists and was editor of the journal, The Chemical Record (Wiley). He retired from Columbia University in 2007, but continues to conduct research.Robert W. Woody is an Emeritus Professor at Colorado State University.

• Preface xiContributors xiiiPart I a Historical Overview 11 the First Decades After the Discovery of Cd and Ord by Aimé Cotton in 1895 3Peter LaurPart II Organic Stereochemistry 372 Some Inherently Chiral Chromophores—empirical Rules and Quantum Chemical Calculations 39Marcin Kwit, Pawel Skowronek, Jacek Gawronski, Jadwiga Frelek, Magdalena Woznica, and Aleksandra Butkiewicz3 Electronic Cd of Benzene and other Aromatic Chromophores for Determination of Absolute Configuration 73Tibor Kurtán, Sándor Antus, and Gennaro Pescitelli4 Electronic Cd Exciton Chirality Method: Principles and Applications 115Nobuyuki Harada, Koji Nakanishi, and Nina Berova Copyrighted Material5 CD SPECTRA OF CHIRAL EXTENDED π-ELECTRON COMPOUNDS: Theoretical Determination of the Absolute Stereochemistry and Experimental Verification 167Nobuyuki Harada and Shunsuke Kuwahara6 Assignment of the Absolute Configurations of Natural Products by Means of Solid-state Electronic Circular Dichroism and Quantum Mechanical Calculations 217Gennaro Pescitelli, Tibor Kurtán, and Karsten Krohn7 Dynamic Stereochemistry and Chiroptical Spectroscopy of Metallo-organic Compounds 251James W. Canary and Zhaohua Dai8 Circular Dichroism of Dynamic Systems: Switching Molecular and Supramolecular Chirality 289Angela Mammana, Gregory T. Carroll, and Ben L. Feringa9 Electronic Circular Dichroism of Supramolecular Systems 317Cheng Yang and Yoshihisa Inoue10 the Online Stereochemical Analysis of Chiral Compounds by Hplc-ecd Coupling in Combination with Quantum-chemical Calculations 355Gerhard Bringmann, Daniel Götz, and Torsten Bruhn11 Determination of the Structures of Chiral Natural Products Using Vibrational Circular Dichroism 387Prasad L. Polavarapu12 Determination of Molecular Absolute Configuration: Guidelines for Selecting a Suitable Chiroptical Approach 421Stefano Superchi, Carlo Rosini, Giuseppe Mazzeo, and Egidio GiorgioPart III Inorganic Stereochemistry 44913 Applications of Electronic Circular Dichroism to Inorganic Stereochemistry 451Sumio KaizakiPart IV Biomolecules 47314 Electronic Circular Dichroism of Proteins 475Robert W. Woody15 Electronic Circular Dichroism of Peptides 499Claudio Toniolo, Fernando Formaggio, and Robert W. Woody16 Electronic Circular Dichroism of Peptidomimetics 545Claudio Toniolo and Fernando Formaggio17 Circular Dichroism Spectroscopy of Nucleic Acids 575Jaroslav Kypr, Iva Kejnovská, Klára Bednářová, and Michaela Vorlíčková18 Electronic Circular Dichroism of Peptide Nucleic Acids And Their Analogues 587Roberto Corradini, Tullia Tedeschi, Stefano Sforza, and Rosangela Marchelli19 Circular Dichroism of Protein–nucleic Acid Interactions 615Donald M. Gray20 Drug and Natural Product Binding to Nucleic Acids Analyzed by Electronic Circular Dichroism 635George A. Ellestad21 Probing Hsa and Agp Drug-binding Sites by Electronic Circular Dichroism 665Miklós Simonyi22 Conformational Studies of Biopolymers, Peptides, Proteins, and Nucleic Acids. a Role for Vibrational Circular Dichroism 707Timothy A. Keiderling and Ahmed Lakhani23 Structure and Behavior of Biomolecules From Raman Optical Activity 759Laurence D. Barron and Lutz Hecht24 Optical Rotation, Electronic Circular Dichroism, and Vibrational Circular Dichroism of Carbohydrates and Glycoconjugates 795Tohru Taniguchi and Kenji Monde25 Electronic Circular Dichroism in Drug Discovery 819Carlo Bertucci and Marco PistolozziIndex 843

Nina Berova is a Research Professor in the Department of Chemistry at Columbia University. She has been a coeditor of the journal Chirality (Wiley) since 1998.Prasad L. Polavarapu is currently a Professor of Chemistry at Vanderbilt University.Koji Nakanishi is one of the world's leading natural products chemists and was editor of the journal, The Chemical Record (Wiley). He retired from Columbia University in 2007, but continues to conduct research.Robert W. Woody is an Emeritus Professor at Colorado State University.

• Preface xiContributors xiiiPart I a Historical Overview 11 the First Decades After the Discovery of Cd and Ord by Aimé Cotton in 1895 3Peter LaurPart II Organic Stereochemistry 372 Some Inherently Chiral Chromophores—empirical Rules and Quantum Chemical Calculations 39Marcin Kwit, Pawel Skowronek, Jacek Gawronski, Jadwiga Frelek, Magdalena Woznica, and Aleksandra Butkiewicz3 Electronic Cd of Benzene and other Aromatic Chromophores for Determination of Absolute Configuration 73Tibor Kurtán, Sándor Antus, and Gennaro Pescitelli4 Electronic Cd Exciton Chirality Method: Principles and Applications 115Nobuyuki Harada, Koji Nakanishi, and Nina Berova Copyrighted Material5 CD SPECTRA OF CHIRAL EXTENDED π-ELECTRON COMPOUNDS: Theoretical Determination of the Absolute Stereochemistry and Experimental Verification 167Nobuyuki Harada and Shunsuke Kuwahara6 Assignment of the Absolute Configurations of Natural Products by Means of Solid-state Electronic Circular Dichroism and Quantum Mechanical Calculations 217Gennaro Pescitelli, Tibor Kurtán, and Karsten Krohn7 Dynamic Stereochemistry and Chiroptical Spectroscopy of Metallo-organic Compounds 251James W. Canary and Zhaohua Dai8 Circular Dichroism of Dynamic Systems: Switching Molecular and Supramolecular Chirality 289Angela Mammana, Gregory T. Carroll, and Ben L. Feringa9 Electronic Circular Dichroism of Supramolecular Systems 317Cheng Yang and Yoshihisa Inoue10 the Online Stereochemical Analysis of Chiral Compounds by Hplc-ecd Coupling in Combination with Quantum-chemical Calculations 355Gerhard Bringmann, Daniel Götz, and Torsten Bruhn11 Determination of the Structures of Chiral Natural Products Using Vibrational Circular Dichroism 387Prasad L. Polavarapu12 Determination of Molecular Absolute Configuration: Guidelines for Selecting a Suitable Chiroptical Approach 421Stefano Superchi, Carlo Rosini, Giuseppe Mazzeo, and Egidio GiorgioPart III Inorganic Stereochemistry 44913 Applications of Electronic Circular Dichroism to Inorganic Stereochemistry 451Sumio KaizakiPart IV Biomolecules 47314 Electronic Circular Dichroism of Proteins 475Robert W. Woody15 Electronic Circular Dichroism of Peptides 499Claudio Toniolo, Fernando Formaggio, and Robert W. Woody16 Electronic Circular Dichroism of Peptidomimetics 545Claudio Toniolo and Fernando Formaggio17 Circular Dichroism Spectroscopy of Nucleic Acids 575Jaroslav Kypr, Iva Kejnovská, Klára Bednářová, and Michaela Vorlíčková18 Electronic Circular Dichroism of Peptide Nucleic Acids And Their Analogues 587Roberto Corradini, Tullia Tedeschi, Stefano Sforza, and Rosangela Marchelli19 Circular Dichroism of Protein–nucleic Acid Interactions 615Donald M. Gray20 Drug and Natural Product Binding to Nucleic Acids Analyzed by Electronic Circular Dichroism 635George A. Ellestad21 Probing Hsa and Agp Drug-binding Sites by Electronic Circular Dichroism 665Miklós Simonyi22 Conformational Studies of Biopolymers, Peptides, Proteins, and Nucleic Acids. a Role for Vibrational Circular Dichroism 707Timothy A. Keiderling and Ahmed Lakhani23 Structure and Behavior of Biomolecules From Raman Optical Activity 759Laurence D. Barron and Lutz Hecht24 Optical Rotation, Electronic Circular Dichroism, and Vibrational Circular Dichroism of Carbohydrates and Glycoconjugates 795Tohru Taniguchi and Kenji Monde25 Electronic Circular Dichroism in Drug Discovery 819Carlo Bertucci and Marco PistolozziIndex 843

Nina Berova is a Research Professor in the Department of Chemistry at Columbia University. She has been a coeditor of the journal Chirality (Wiley) since 1998.Prasad L. Polavarapu is currently a Professor of Chemistry at Vanderbilt University.Koji Nakanishi is one of the world's leading natural products chemists and was editor of the journal, The Chemical Record (Wiley). He retired from Columbia University in 2007, but continues to conduct research.Robert W. Woody is an Emeritus Professor at Colorado State University.

• Preface xiContributors xiiiPart I a Historical Overview 11 the First Decades After the Discovery of Cd and Ord by Aimé Cotton in 1895 3Peter LaurPart II Organic Stereochemistry 372 Some Inherently Chiral Chromophores—empirical Rules and Quantum Chemical Calculations 39Marcin Kwit, Pawel Skowronek, Jacek Gawronski, Jadwiga Frelek, Magdalena Woznica, and Aleksandra Butkiewicz3 Electronic Cd of Benzene and other Aromatic Chromophores for Determination of Absolute Configuration 73Tibor Kurtán, Sándor Antus, and Gennaro Pescitelli4 Electronic Cd Exciton Chirality Method: Principles and Applications 115Nobuyuki Harada, Koji Nakanishi, and Nina Berova Copyrighted Material5 CD SPECTRA OF CHIRAL EXTENDED π-ELECTRON COMPOUNDS: Theoretical Determination of the Absolute Stereochemistry and Experimental Verification 167Nobuyuki Harada and Shunsuke Kuwahara6 Assignment of the Absolute Configurations of Natural Products by Means of Solid-state Electronic Circular Dichroism and Quantum Mechanical Calculations 217Gennaro Pescitelli, Tibor Kurtán, and Karsten Krohn7 Dynamic Stereochemistry and Chiroptical Spectroscopy of Metallo-organic Compounds 251James W. Canary and Zhaohua Dai8 Circular Dichroism of Dynamic Systems: Switching Molecular and Supramolecular Chirality 289Angela Mammana, Gregory T. Carroll, and Ben L. Feringa9 Electronic Circular Dichroism of Supramolecular Systems 317Cheng Yang and Yoshihisa Inoue10 the Online Stereochemical Analysis of Chiral Compounds by Hplc-ecd Coupling in Combination with Quantum-chemical Calculations 355Gerhard Bringmann, Daniel Götz, and Torsten Bruhn11 Determination of the Structures of Chiral Natural Products Using Vibrational Circular Dichroism 387Prasad L. Polavarapu12 Determination of Molecular Absolute Configuration: Guidelines for Selecting a Suitable Chiroptical Approach 421Stefano Superchi, Carlo Rosini, Giuseppe Mazzeo, and Egidio GiorgioPart III Inorganic Stereochemistry 44913 Applications of Electronic Circular Dichroism to Inorganic Stereochemistry 451Sumio KaizakiPart IV Biomolecules 47314 Electronic Circular Dichroism of Proteins 475Robert W. Woody15 Electronic Circular Dichroism of Peptides 499Claudio Toniolo, Fernando Formaggio, and Robert W. Woody16 Electronic Circular Dichroism of Peptidomimetics 545Claudio Toniolo and Fernando Formaggio17 Circular Dichroism Spectroscopy of Nucleic Acids 575Jaroslav Kypr, Iva Kejnovská, Klára Bednářová, and Michaela Vorlíčková18 Electronic Circular Dichroism of Peptide Nucleic Acids And Their Analogues 587Roberto Corradini, Tullia Tedeschi, Stefano Sforza, and Rosangela Marchelli19 Circular Dichroism of Protein–nucleic Acid Interactions 615Donald M. Gray20 Drug and Natural Product Binding to Nucleic Acids Analyzed by Electronic Circular Dichroism 635George A. Ellestad21 Probing Hsa and Agp Drug-binding Sites by Electronic Circular Dichroism 665Miklós Simonyi22 Conformational Studies of Biopolymers, Peptides, Proteins, and Nucleic Acids. a Role for Vibrational Circular Dichroism 707Timothy A. Keiderling and Ahmed Lakhani23 Structure and Behavior of Biomolecules From Raman Optical Activity 759Laurence D. Barron and Lutz Hecht24 Optical Rotation, Electronic Circular Dichroism, and Vibrational Circular Dichroism of Carbohydrates and Glycoconjugates 795Tohru Taniguchi and Kenji Monde25 Electronic Circular Dichroism in Drug Discovery 819Carlo Bertucci and Marco PistolozziIndex 843