Richard L. Doty is a professor and director of the Smell and Taste Center at the University of Pennsylvania. He serves as an editorial consultant to over 50 scientific and medical journals, as well as dozens of major corporations and governmental advisory committees, and he has authored or edited over 350 scientific publications and books, including the previous two editions of Handbook of Olfaction and Gustation.

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• Foreword xiGordon M. ShepherdPreface xiiiRichard L. DotyContributors xvPart 1 General Introduction1 Introduction and Historical Perspective 3Richard L. DotyPart 2 OlfactionOlfactory Anatomy and Neurobiology2 Anatomy of the Nasal Passages in Mammals 39Timothy D. Smith, Thomas P. Eiting, and Kunwar P. Bhatnagar3 Olfactory Mucosa: Composition, Enzymatic Localization, and Metabolism 63Xinxin Ding and Fang Xie4 Development, Morphology, and Functional Anatomy of the Olfactory Epithelium 93John C. Dennis, Shelly Aono, Vitaly J. Vodyanoy, and Edward E. Morrison5 Olfactory Receptor Function 109Keiichi Yoshikawa and Kazushige Touhara6 Odorant Receptor Gene Regulation 123Akio Tsuboi and Hitoshi Sakano7 Neurogenesis in the Adult Olfactory Epithelium 133Alan Mackay-Sim, James St John, and James E. Schwob8 Anatomy and Neurobiology of the Main and Accessory Olfactory Bulbs 157Matthew Ennis and Timothy E. Holy9 Adult Neurogenesis in the Subventricular Zone and Migration to the Olfactory Bulb 183John W. Cave and Harriet Baker10 Cortical Olfactory Anatomy and Physiology 209Donald A. Wilson, Julie Chapuis, and Regina M. SullivanPart 3 Human Olfactory Measurement, Physiology, and Development11 Psychophysical Measurement of Human Olfactory Function 227Richard L. Doty and David G. Laing12 Electrophysiological Measurement of Olfactory Function 261Allen Osman and Jonathan Silas13 Structural and Functional Imaging of the Human Olfactory System 279Jay A. Gottfried14 Prenatal and Postnatal Human Olfactory Development: Influences on Cognition and Behavior 305Benoist Schaal15 Olfactory Memory 337Theresa L. White, Per Møller, E. P. Köster, Howard Eichenbaum, and Christiane LinsterPart 4 Clinical Applications and Perspectives16 Nasal Patency and the Aerodynamics of Nasal Airflow in Relation to Olfactory Function 355Kai Zhao and Richard E. Frye17 Clinical Disorders of Olfaction 375Richard L. Doty18 Odor Perception and Neuropathology in Neurodegenerative Diseases and Schizophrenia 403Richard L. Doty, Christopher H. Hawkes, Kimberley P. Good, and John E. Duda19 The Olfactory System as a Route of Delivery for Agents to the Brain and Circulation 453Mary Beth Genter, Mansi Krishan, and Rui Daniel Prediger20 Influence of Toxins on Olfactory Function and their Potential Association with Neurodegenerative Disease 485Lilian Calderón-GarcidueñasPart 5 Olfaction in Nonhuman Forms21 Microbial Chemical Sensing 513Judith Van Houten22 Olfaction in Insects 531Paul Szyszka and C. Giovanni Galizia23 Olfaction in Aquatic Vertebrates 547Keith B. Tierney24 The Chemistry of Avian Odors: An Introduction to Best Practices 565Gabrielle A. Nevitt and Paola A. Prada25 Olfactory Communication in Rodents in Natural and Semi-Natural Habitats 579Daniel W. Wesson26 Olfaction in the Order Carnivora: Family Canidae 591Peter Hepper and Deborah Wells27 Olfaction in Nonhuman Primates 605Matthias Laska and Laura Teresa Hernandez SalazarPart 6 GustationTaste Anatomy and Neurobiology28 The Role of Saliva in Taste Transduction 625Ryuji Matsuo and Guy H. Carpenter29 Anatomy of the Tongue and Taste Buds 637Martin Witt and Klaus Reutter30 Chemical Modulators of Taste 665John A. DeSimone, Grant E. Dubois, and Vijay Lyall31 The Molecular Basis of Gustatory Transduction 685Steven D. Munger and Wolfgang Meyerhof32 Central Taste Anatomy and Physiology of Rodents and Primates 701Thomas C. Pritchard and Patricia M. Di Lorenzo33 Development of the Taste System 727Robin F. Krimm, Shoba Thirumangalathu, and Linda A. BarlowPart 7 Human Taste Measurement, Physiology, and Development34 Psychophysical Measures of Human Oral Sensation 751Derek J. Snyder, Charles A. Sims, and Linda M. Bartoshuk35 Mapping Brain Activity in Response to Taste Stimulation 775Dana M. Small and Annick Faurion36 The Ontogeny of Taste Perception and Preference Throughout Childhood 795Catherine A. Forestell and Julie A. MennellaPart 8 Clinical Applications and Perspectives37 Nutritional Implications of Taste and Smell Dysfunction 831Janice Lee, Robin M. Tucker, Sze Yen Tan, Cordelia A. Running, Joshua B. Jones, and Richard D. Mattes38 Conditioned Taste Aversions 865Kathleen C. Chambers39 Clinical Disorders Affecting Taste: An Update 887Steven M. Bromley and Richard L. Doty40 Influence of Drugs on Taste Function 911Susan S. SchiffmanPart 9 Taste in Nonhuman Species41 Taste Processing in Insects 929John I. Glendinning42 Taste in Aquatic Vertebrates 947Toshiaki J. Hara43 Comparative Taste Biology with Special Focus on Birds and Reptiles 957Hannah M. Rowland, M. Rockwell Parker, Peihua Jiang, Danielle R. Reed, and Gary K. Beauchamp44 Functional Organization of the Gustatory System in Macaques 983Thomas C. Pritchard and Thomas R. ScottPart 10 Central Integration of Olfaction, Taste, and the Other Senses45 Chemosensory Integration and the Perception of Flavor 1007John Prescott and Richard Stevenson46 Neural Integration of Taste, Smell, Oral Texture, and Visual Modalities 1027Edmund T. RollsPart 11 Industrial Applications and Perspectives47 Olfaction and Taste in the Food and Beverage Industries 1051Graham A. Bell and Wendy V. Parr48 Olfaction and Gustation in the Flavor and Fragrance Industries 1067Benjamin Mattei, Arnaud Montet, and Matthias H. Tabert49 The Smell and Taste of Public Drinking Water 1079Gary A. Burlingame and Richard L. DotyPart 12 Other Chemosensory Systems50 Trigeminal Chemesthesis 1091J. Enrique Cometto-Mu˜niz and Christopher Simons51 The Vomeronasal Organ 1113Lisa Stowers and Marc Spehr52 The Septal Organ, Grueneberg Ganglion, and Terminal Nerve 1133Minghong Ma, Joerg Fleischer, Heinz Breer, and Heather EisthenAuthor Index 1151Subject Index 1197

Richard L. Doty is a professor and director of the Smell and Taste Center at the University of Pennsylvania. He serves as an editorial consultant to over 50 scientific and medical journals, as well as dozens of major corporations and governmental advisory committees, and he has authored or edited over 350 scientific publications and books, including the previous two editions of Handbook of Olfaction and Gustation.

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• Foreword xiGordon M. ShepherdPreface xiiiRichard L. DotyContributors xvPart 1 General Introduction1 Introduction and Historical Perspective 3Richard L. DotyPart 2 OlfactionOlfactory Anatomy and Neurobiology2 Anatomy of the Nasal Passages in Mammals 39Timothy D. Smith, Thomas P. Eiting, and Kunwar P. Bhatnagar3 Olfactory Mucosa: Composition, Enzymatic Localization, and Metabolism 63Xinxin Ding and Fang Xie4 Development, Morphology, and Functional Anatomy of the Olfactory Epithelium 93John C. Dennis, Shelly Aono, Vitaly J. Vodyanoy, and Edward E. Morrison5 Olfactory Receptor Function 109Keiichi Yoshikawa and Kazushige Touhara6 Odorant Receptor Gene Regulation 123Akio Tsuboi and Hitoshi Sakano7 Neurogenesis in the Adult Olfactory Epithelium 133Alan Mackay-Sim, James St John, and James E. Schwob8 Anatomy and Neurobiology of the Main and Accessory Olfactory Bulbs 157Matthew Ennis and Timothy E. Holy9 Adult Neurogenesis in the Subventricular Zone and Migration to the Olfactory Bulb 183John W. Cave and Harriet Baker10 Cortical Olfactory Anatomy and Physiology 209Donald A. Wilson, Julie Chapuis, and Regina M. SullivanPart 3 Human Olfactory Measurement, Physiology, and Development11 Psychophysical Measurement of Human Olfactory Function 227Richard L. Doty and David G. Laing12 Electrophysiological Measurement of Olfactory Function 261Allen Osman and Jonathan Silas13 Structural and Functional Imaging of the Human Olfactory System 279Jay A. Gottfried14 Prenatal and Postnatal Human Olfactory Development: Influences on Cognition and Behavior 305Benoist Schaal15 Olfactory Memory 337Theresa L. White, Per Møller, E. P. Köster, Howard Eichenbaum, and Christiane LinsterPart 4 Clinical Applications and Perspectives16 Nasal Patency and the Aerodynamics of Nasal Airflow in Relation to Olfactory Function 355Kai Zhao and Richard E. Frye17 Clinical Disorders of Olfaction 375Richard L. Doty18 Odor Perception and Neuropathology in Neurodegenerative Diseases and Schizophrenia 403Richard L. Doty, Christopher H. Hawkes, Kimberley P. Good, and John E. Duda19 The Olfactory System as a Route of Delivery for Agents to the Brain and Circulation 453Mary Beth Genter, Mansi Krishan, and Rui Daniel Prediger20 Influence of Toxins on Olfactory Function and their Potential Association with Neurodegenerative Disease 485Lilian Calderón-GarcidueñasPart 5 Olfaction in Nonhuman Forms21 Microbial Chemical Sensing 513Judith Van Houten22 Olfaction in Insects 531Paul Szyszka and C. Giovanni Galizia23 Olfaction in Aquatic Vertebrates 547Keith B. Tierney24 The Chemistry of Avian Odors: An Introduction to Best Practices 565Gabrielle A. Nevitt and Paola A. Prada25 Olfactory Communication in Rodents in Natural and Semi-Natural Habitats 579Daniel W. Wesson26 Olfaction in the Order Carnivora: Family Canidae 591Peter Hepper and Deborah Wells27 Olfaction in Nonhuman Primates 605Matthias Laska and Laura Teresa Hernandez SalazarPart 6 GustationTaste Anatomy and Neurobiology28 The Role of Saliva in Taste Transduction 625Ryuji Matsuo and Guy H. Carpenter29 Anatomy of the Tongue and Taste Buds 637Martin Witt and Klaus Reutter30 Chemical Modulators of Taste 665John A. DeSimone, Grant E. Dubois, and Vijay Lyall31 The Molecular Basis of Gustatory Transduction 685Steven D. Munger and Wolfgang Meyerhof32 Central Taste Anatomy and Physiology of Rodents and Primates 701Thomas C. Pritchard and Patricia M. Di Lorenzo33 Development of the Taste System 727Robin F. Krimm, Shoba Thirumangalathu, and Linda A. BarlowPart 7 Human Taste Measurement, Physiology, and Development34 Psychophysical Measures of Human Oral Sensation 751Derek J. Snyder, Charles A. Sims, and Linda M. Bartoshuk35 Mapping Brain Activity in Response to Taste Stimulation 775Dana M. Small and Annick Faurion36 The Ontogeny of Taste Perception and Preference Throughout Childhood 795Catherine A. Forestell and Julie A. MennellaPart 8 Clinical Applications and Perspectives37 Nutritional Implications of Taste and Smell Dysfunction 831Janice Lee, Robin M. Tucker, Sze Yen Tan, Cordelia A. Running, Joshua B. Jones, and Richard D. Mattes38 Conditioned Taste Aversions 865Kathleen C. Chambers39 Clinical Disorders Affecting Taste: An Update 887Steven M. Bromley and Richard L. Doty40 Influence of Drugs on Taste Function 911Susan S. SchiffmanPart 9 Taste in Nonhuman Species41 Taste Processing in Insects 929John I. Glendinning42 Taste in Aquatic Vertebrates 947Toshiaki J. Hara43 Comparative Taste Biology with Special Focus on Birds and Reptiles 957Hannah M. Rowland, M. Rockwell Parker, Peihua Jiang, Danielle R. Reed, and Gary K. Beauchamp44 Functional Organization of the Gustatory System in Macaques 983Thomas C. Pritchard and Thomas R. ScottPart 10 Central Integration of Olfaction, Taste, and the Other Senses45 Chemosensory Integration and the Perception of Flavor 1007John Prescott and Richard Stevenson46 Neural Integration of Taste, Smell, Oral Texture, and Visual Modalities 1027Edmund T. RollsPart 11 Industrial Applications and Perspectives47 Olfaction and Taste in the Food and Beverage Industries 1051Graham A. Bell and Wendy V. Parr48 Olfaction and Gustation in the Flavor and Fragrance Industries 1067Benjamin Mattei, Arnaud Montet, and Matthias H. Tabert49 The Smell and Taste of Public Drinking Water 1079Gary A. Burlingame and Richard L. DotyPart 12 Other Chemosensory Systems50 Trigeminal Chemesthesis 1091J. Enrique Cometto-Mu˜niz and Christopher Simons51 The Vomeronasal Organ 1113Lisa Stowers and Marc Spehr52 The Septal Organ, Grueneberg Ganglion, and Terminal Nerve 1133Minghong Ma, Joerg Fleischer, Heinz Breer, and Heather EisthenAuthor Index 1151Subject Index 1197

Richard L. Doty is a professor and director of the Smell and Taste Center at the University of Pennsylvania. He serves as an editorial consultant to over 50 scientific and medical journals, as well as dozens of major corporations and governmental advisory committees, and he has authored or edited over 350 scientific publications and books, including the previous two editions of Handbook of Olfaction and Gustation.

Select Guide Rating

• Foreword xiGordon M. ShepherdPreface xiiiRichard L. DotyContributors xvPart 1 General Introduction1 Introduction and Historical Perspective 3Richard L. DotyPart 2 OlfactionOlfactory Anatomy and Neurobiology2 Anatomy of the Nasal Passages in Mammals 39Timothy D. Smith, Thomas P. Eiting, and Kunwar P. Bhatnagar3 Olfactory Mucosa: Composition, Enzymatic Localization, and Metabolism 63Xinxin Ding and Fang Xie4 Development, Morphology, and Functional Anatomy of the Olfactory Epithelium 93John C. Dennis, Shelly Aono, Vitaly J. Vodyanoy, and Edward E. Morrison5 Olfactory Receptor Function 109Keiichi Yoshikawa and Kazushige Touhara6 Odorant Receptor Gene Regulation 123Akio Tsuboi and Hitoshi Sakano7 Neurogenesis in the Adult Olfactory Epithelium 133Alan Mackay-Sim, James St John, and James E. Schwob8 Anatomy and Neurobiology of the Main and Accessory Olfactory Bulbs 157Matthew Ennis and Timothy E. Holy9 Adult Neurogenesis in the Subventricular Zone and Migration to the Olfactory Bulb 183John W. Cave and Harriet Baker10 Cortical Olfactory Anatomy and Physiology 209Donald A. Wilson, Julie Chapuis, and Regina M. SullivanPart 3 Human Olfactory Measurement, Physiology, and Development11 Psychophysical Measurement of Human Olfactory Function 227Richard L. Doty and David G. Laing12 Electrophysiological Measurement of Olfactory Function 261Allen Osman and Jonathan Silas13 Structural and Functional Imaging of the Human Olfactory System 279Jay A. Gottfried14 Prenatal and Postnatal Human Olfactory Development: Influences on Cognition and Behavior 305Benoist Schaal15 Olfactory Memory 337Theresa L. White, Per Møller, E. P. Köster, Howard Eichenbaum, and Christiane LinsterPart 4 Clinical Applications and Perspectives16 Nasal Patency and the Aerodynamics of Nasal Airflow in Relation to Olfactory Function 355Kai Zhao and Richard E. Frye17 Clinical Disorders of Olfaction 375Richard L. Doty18 Odor Perception and Neuropathology in Neurodegenerative Diseases and Schizophrenia 403Richard L. Doty, Christopher H. Hawkes, Kimberley P. Good, and John E. Duda19 The Olfactory System as a Route of Delivery for Agents to the Brain and Circulation 453Mary Beth Genter, Mansi Krishan, and Rui Daniel Prediger20 Influence of Toxins on Olfactory Function and their Potential Association with Neurodegenerative Disease 485Lilian Calderón-GarcidueñasPart 5 Olfaction in Nonhuman Forms21 Microbial Chemical Sensing 513Judith Van Houten22 Olfaction in Insects 531Paul Szyszka and C. Giovanni Galizia23 Olfaction in Aquatic Vertebrates 547Keith B. Tierney24 The Chemistry of Avian Odors: An Introduction to Best Practices 565Gabrielle A. Nevitt and Paola A. Prada25 Olfactory Communication in Rodents in Natural and Semi-Natural Habitats 579Daniel W. Wesson26 Olfaction in the Order Carnivora: Family Canidae 591Peter Hepper and Deborah Wells27 Olfaction in Nonhuman Primates 605Matthias Laska and Laura Teresa Hernandez SalazarPart 6 GustationTaste Anatomy and Neurobiology28 The Role of Saliva in Taste Transduction 625Ryuji Matsuo and Guy H. Carpenter29 Anatomy of the Tongue and Taste Buds 637Martin Witt and Klaus Reutter30 Chemical Modulators of Taste 665John A. DeSimone, Grant E. Dubois, and Vijay Lyall31 The Molecular Basis of Gustatory Transduction 685Steven D. Munger and Wolfgang Meyerhof32 Central Taste Anatomy and Physiology of Rodents and Primates 701Thomas C. Pritchard and Patricia M. Di Lorenzo33 Development of the Taste System 727Robin F. Krimm, Shoba Thirumangalathu, and Linda A. BarlowPart 7 Human Taste Measurement, Physiology, and Development34 Psychophysical Measures of Human Oral Sensation 751Derek J. Snyder, Charles A. Sims, and Linda M. Bartoshuk35 Mapping Brain Activity in Response to Taste Stimulation 775Dana M. Small and Annick Faurion36 The Ontogeny of Taste Perception and Preference Throughout Childhood 795Catherine A. Forestell and Julie A. MennellaPart 8 Clinical Applications and Perspectives37 Nutritional Implications of Taste and Smell Dysfunction 831Janice Lee, Robin M. Tucker, Sze Yen Tan, Cordelia A. Running, Joshua B. Jones, and Richard D. Mattes38 Conditioned Taste Aversions 865Kathleen C. Chambers39 Clinical Disorders Affecting Taste: An Update 887Steven M. Bromley and Richard L. Doty40 Influence of Drugs on Taste Function 911Susan S. SchiffmanPart 9 Taste in Nonhuman Species41 Taste Processing in Insects 929John I. Glendinning42 Taste in Aquatic Vertebrates 947Toshiaki J. Hara43 Comparative Taste Biology with Special Focus on Birds and Reptiles 957Hannah M. Rowland, M. Rockwell Parker, Peihua Jiang, Danielle R. Reed, and Gary K. Beauchamp44 Functional Organization of the Gustatory System in Macaques 983Thomas C. Pritchard and Thomas R. ScottPart 10 Central Integration of Olfaction, Taste, and the Other Senses45 Chemosensory Integration and the Perception of Flavor 1007John Prescott and Richard Stevenson46 Neural Integration of Taste, Smell, Oral Texture, and Visual Modalities 1027Edmund T. RollsPart 11 Industrial Applications and Perspectives47 Olfaction and Taste in the Food and Beverage Industries 1051Graham A. Bell and Wendy V. Parr48 Olfaction and Gustation in the Flavor and Fragrance Industries 1067Benjamin Mattei, Arnaud Montet, and Matthias H. Tabert49 The Smell and Taste of Public Drinking Water 1079Gary A. Burlingame and Richard L. DotyPart 12 Other Chemosensory Systems50 Trigeminal Chemesthesis 1091J. Enrique Cometto-Mu˜niz and Christopher Simons51 The Vomeronasal Organ 1113Lisa Stowers and Marc Spehr52 The Septal Organ, Grueneberg Ganglion, and Terminal Nerve 1133Minghong Ma, Joerg Fleischer, Heinz Breer, and Heather EisthenAuthor Index 1151Subject Index 1197