Professor Julie A Lovegrove, Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular Research, Department of Food and Nutritional Sciences, University of Reading, UK.Associate Professor Leanne Hodson, Oxford Centre for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine, University of Oxford, UK.Professor Sangita Sharma, Centennial Professor, Endowed Chair in Aboriginal Health, Professor of Aboriginal & Global Health Research, Aboriginal and Global Health Research Group, Department of Medicine, Faculty of Medicine & Dentistry, University of Alberta, Canada.Professor Susan A Lanham-New, Department of Nutritional Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, UK.

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• Contributors viiSeries Foreword ixPreface xAbout the Companion Website xii 1 Nature, Purpose and Implications of Research in Nutrition 1Alan A Jackson, Stephen A Wootton and Martin Wiseman2 Study Design: Population-Based Studies 13Janet Cade and Jayne Hutchinson3 Study Design: Intervention Studies 28Jayne V Woodside, Robert W Welch, Chris C Patterson and Michelle C McKinley4 Methods to Determine Dietary Intake 48Nadia Slimani, Heinz Freisling, Anne-Kathrin Illner and Inge Huybrechts5 Food Composition 71Barbara Burlingame and U Ruth Charrondiere6 Biomarkers of Intake 90Gunter G C Kuhnle7 Methods of Data Analysis 108Graham Horgan8 Considerations for Including Different Population Groups in Nutrition Research 123Maria J Maynard9 Use of Biobanks in Nutrition Research 141Kurt Zatloukal, Pieter van’t Veer, Christian Viertler, Marc-Jeroen Bogaardt and Peter Hollman10 Methods Investigating Food-Related Behaviour 151Moira Dean, Monique M Raats and Liisa Lähteenmäki11 Methods for Assessing Nutritional Status and Body Composition 169Peter Murgatroyd, Les Bluck and Laura Watson12 Energy Expenditure and Intake Methods 186Klaas R Westerterp13 Application of ‘Omics’ Technologies 198Helen M Roche, Baukje de Roos and Lorraine Brennan14 Epigenetics 212John C Mathers15 Nutrient–Gene Interactions 225Anne Marie Minihane16 Data Analytical Methods for the Application of Systems Biology in Nutrition 235Corrado Priami and Melissa J Morine17 Stable Isotopes in Nutrition Research 250Margot Umpleby and Barbara A Fielding18 Animal Models in Nutrition Research 265Andrew M Salter19 Cellular Models in Nutrition Research 278Kathleen M Botham20 Translation of Nutrition Research 307Judith ButtrissGlossary 326Index 335

Professor Julie A Lovegrove, Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular Research, Department of Food and Nutritional Sciences, University of Reading, UK.Associate Professor Leanne Hodson, Oxford Centre for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine, University of Oxford, UK.Professor Sangita Sharma, Centennial Professor, Endowed Chair in Aboriginal Health, Professor of Aboriginal & Global Health Research, Aboriginal and Global Health Research Group, Department of Medicine, Faculty of Medicine & Dentistry, University of Alberta, Canada.Professor Susan A Lanham-New, Department of Nutritional Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, UK.

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• Contributors viiSeries Foreword ixPreface xAbout the Companion Website xii 1 Nature, Purpose and Implications of Research in Nutrition 1Alan A Jackson, Stephen A Wootton and Martin Wiseman2 Study Design: Population-Based Studies 13Janet Cade and Jayne Hutchinson3 Study Design: Intervention Studies 28Jayne V Woodside, Robert W Welch, Chris C Patterson and Michelle C McKinley4 Methods to Determine Dietary Intake 48Nadia Slimani, Heinz Freisling, Anne-Kathrin Illner and Inge Huybrechts5 Food Composition 71Barbara Burlingame and U Ruth Charrondiere6 Biomarkers of Intake 90Gunter G C Kuhnle7 Methods of Data Analysis 108Graham Horgan8 Considerations for Including Different Population Groups in Nutrition Research 123Maria J Maynard9 Use of Biobanks in Nutrition Research 141Kurt Zatloukal, Pieter van’t Veer, Christian Viertler, Marc-Jeroen Bogaardt and Peter Hollman10 Methods Investigating Food-Related Behaviour 151Moira Dean, Monique M Raats and Liisa Lähteenmäki11 Methods for Assessing Nutritional Status and Body Composition 169Peter Murgatroyd, Les Bluck and Laura Watson12 Energy Expenditure and Intake Methods 186Klaas R Westerterp13 Application of ‘Omics’ Technologies 198Helen M Roche, Baukje de Roos and Lorraine Brennan14 Epigenetics 212John C Mathers15 Nutrient–Gene Interactions 225Anne Marie Minihane16 Data Analytical Methods for the Application of Systems Biology in Nutrition 235Corrado Priami and Melissa J Morine17 Stable Isotopes in Nutrition Research 250Margot Umpleby and Barbara A Fielding18 Animal Models in Nutrition Research 265Andrew M Salter19 Cellular Models in Nutrition Research 278Kathleen M Botham20 Translation of Nutrition Research 307Judith ButtrissGlossary 326Index 335

Professor Julie A Lovegrove, Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular Research, Department of Food and Nutritional Sciences, University of Reading, UK.Associate Professor Leanne Hodson, Oxford Centre for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine, University of Oxford, UK.Professor Sangita Sharma, Centennial Professor, Endowed Chair in Aboriginal Health, Professor of Aboriginal & Global Health Research, Aboriginal and Global Health Research Group, Department of Medicine, Faculty of Medicine & Dentistry, University of Alberta, Canada.Professor Susan A Lanham-New, Department of Nutritional Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, UK.

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• Contributors viiSeries Foreword ixPreface xAbout the Companion Website xii 1 Nature, Purpose and Implications of Research in Nutrition 1Alan A Jackson, Stephen A Wootton and Martin Wiseman2 Study Design: Population-Based Studies 13Janet Cade and Jayne Hutchinson3 Study Design: Intervention Studies 28Jayne V Woodside, Robert W Welch, Chris C Patterson and Michelle C McKinley4 Methods to Determine Dietary Intake 48Nadia Slimani, Heinz Freisling, Anne-Kathrin Illner and Inge Huybrechts5 Food Composition 71Barbara Burlingame and U Ruth Charrondiere6 Biomarkers of Intake 90Gunter G C Kuhnle7 Methods of Data Analysis 108Graham Horgan8 Considerations for Including Different Population Groups in Nutrition Research 123Maria J Maynard9 Use of Biobanks in Nutrition Research 141Kurt Zatloukal, Pieter van’t Veer, Christian Viertler, Marc-Jeroen Bogaardt and Peter Hollman10 Methods Investigating Food-Related Behaviour 151Moira Dean, Monique M Raats and Liisa Lähteenmäki11 Methods for Assessing Nutritional Status and Body Composition 169Peter Murgatroyd, Les Bluck and Laura Watson12 Energy Expenditure and Intake Methods 186Klaas R Westerterp13 Application of ‘Omics’ Technologies 198Helen M Roche, Baukje de Roos and Lorraine Brennan14 Epigenetics 212John C Mathers15 Nutrient–Gene Interactions 225Anne Marie Minihane16 Data Analytical Methods for the Application of Systems Biology in Nutrition 235Corrado Priami and Melissa J Morine17 Stable Isotopes in Nutrition Research 250Margot Umpleby and Barbara A Fielding18 Animal Models in Nutrition Research 265Andrew M Salter19 Cellular Models in Nutrition Research 278Kathleen M Botham20 Translation of Nutrition Research 307Judith ButtrissGlossary 326Index 335