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      NMR in Pharmaceutical Science

      AvJeremy R. Everett,Robin K. Harris

      Inbunden, Engelska, 2015

      Del i serien eMagRes Books

      1 494 kr

      Beställningsvara. Skickas inom 5-8 vardagar. Fri frakt över 249 kr.

      Beskrivning

      NMR in Pharmaceutical Sciences is intended to be a comprehensive source of information for the many individuals that utilize MR in studies of relevance to the pharmaceutical sector. The book is intended to educate and inform those who develop and apply MR approaches within the wider pharmaceutical environment, emphasizing the toolbox that is available to spectroscopists and radiologists.This book is structured on the key processes in drug discovery, development and manufacture, but underpinned by an understanding of fundamental NMR principles and the unique contribution that NMR (including MRI) can provide. After an introductory chapter, which constitutes an overview, the content is organised into five sections. The first section is on the basics of NMR theory and relevant experimental methods. The rest follow a sequence based on the chronology of drug discovery and development, firstly 'Idea to Lead' then 'Lead to Drug Candidate', followed by 'Clinical Development', and finally 'Drug Manufacture'.  The thirty one chapters cover a vast range of topics from analytical chemistry, including aspects involved in regulatory matters and in the prevention of fraud, to clinical imaging studies.Whilst this comprehensive volume will be essential reading for many scientists based in pharmaceutical and related industries, it should also be of considerable value to a much wider range of academic scientists whose research is related to the various aspects of pharmaceutical R&D; for them it will supply vital understanding of pharmaceutical industrial concerns and the basis of key decision making processes.About eMagRes HandbookseMagRes (formerly the Encyclopedia of Magnetic Resonance) publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of eMagRes articles. In consultation with the eMagRes Editorial Board, the eMagRes handbooks are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry.Have the content of this handbook and the complete content of eMagRes at your fingertips!Visit: www.wileyonlinelibrary.com/ref/eMagRes

      Produktinformation

      • Utgivningsdatum:2015-09-18
      • Mått:196 x 254 x 28 mm
      • Vikt:1 247 g
      • Format:Inbunden
      • Språk:Engelska
      • Serie:eMagRes Books
      • Antal sidor:512
      • Förlag:John Wiley & Sons Inc
      • ISBN:9781118660256

      Utforska kategorier

      • Övrig teknik och tillämpad vetenskap inom Naturvetenskap och teknik
      • Medicinsk bildbehandling inom Medicin
      • Tillverkningsteknik inom Naturvetenskap och teknik

      Mer om författaren

      Jeremy R. Everett, Ph.D., Department of Pharmaceutical, Chemical & Environmental Sciences, University of Greenwich, UKJohn C. Lindon, Ph.D., Imperial College London, UKIan D. Wilson, Ph.D., Imperial College London, UKRobin Harris, Ph.D., Department of Chemistry, University of Durham, UK

      Innehållsförteckning

      • Contributors xiSeries Preface xviiPreface xixPart A: Introduction 11 Drug Discovery and Development: The Role of NMRJeremy R. Everett 3Part B: NMR Theory & Experimental Methods 212 Modern NMR Pulse Sequences in Pharmaceutical R&DJohn A. Parkinson 233 Experimental NMR Methods for Pharmaceutical Research and DevelopmentAnthony C. Dona 414 19F NMR Spectroscopy: Applications in Pharmaceutical StudiesJohn C. Lindon and Ian D. Wilson 535 Quantitative NMR Spectroscopy in Pharmaceutical R&DUlrike Holzgrabe 636 High-throughput NMR in Pharmaceutical R&DJohn C. Hollerton 797 Multivariate Data Analysis Methods for NMR-based Metabolic Phenotyping in Pharmaceutical and Clinical ResearchKirill A. Veselkov, James S. McKenzie, and Jeremy K. Nicholson 89Part C: Idea to Lead 1038 The Role of NMR in Target Identification and Validation for Pharmaceutical R&DKrishna Saxena and Harald Schwalbe 1059 High-resolution MAS NMR of Tissues and CellsLeo L. Cheng 11710 NMR Studies of Inborn Errors of MetabolismSarantos Kostidis and Emmanuel Mikros 13111 NMR-based Structure Confirmation of Hits and Leads in Pharmaceutical R&DPhilip J. Sidebottom 14712 Fragment-based Drug Design Using NMR MethodsLeonor Puchades-Carrasco and Antonio Pineda-Lucena 15513 Hit Discovery from Natural Products in Pharmaceutical R&DOlivia Corcoran 173Part D: Lead to Drug Candidate 18314 NMR-based Structure Determination of Drug Leads and CandidatesTorren M. Peakman 18515 Mixture Analysis in Pharmaceutical R&D Using Hyphenated NMR TechniquesIan D. Wilson and John C. Lindon 19716 Conformation and Stereochemical Analysis of Drug MoleculesGary J. Sharman 20717 NMR Methods for the Assignment of Absolute Stereochemistry of Bioactive CompoundsJose M. Seco and Ricardo Riguera 22118 Applications of Preclinical MRI/MRS in the Evaluation of Drug Efficacy and SafetyThomas M. Bocan, Lauren Keith, and David M. Thomasson 25519 Practical Applications of NMR Spectroscopy in Preclinical Drug Metabolism StudiesRaman Sharma and Gregory S. Walker 26720 Preclinical Drug Efficacy and Safety Using NMR SpectroscopyMuireann Coen and Ian D. Wilson 28121 Characterization of Pharmaceutical Compounds by Solid-state NMRFrederick G. Vogt 29722 Structure-based Drug Design Using NMRMark Jeeves, Lee Quill, and Michael Overduin 31723 Pharmaceutical Technology Studied by MRIDavid G. Reid and Stephen J. Byard 331Part E: Clinical Development 34524 NMR-based Metabolic Phenotyping for Disease Diagnosis and StratificationBeatriz Jiménez 34725 NMR-based Pharmacometabonomics: A New Approach to Personalized MedicineJeremy R. Everett 35926 Clinical MRI Studies of Drug Efficacy and SafetyDavid G. Reid, Paul D. Hockings, and Nadeem Saeed 37327 The Role of NMR in the Protection of Intellectual Property in Pharmaceutical R&DFrederick G. Vogt 385Part F: Drug Manufacture 39528 Analysis of Counterfeit Medicines and Adulterated Dietary Supplements by NMRMyriam Malet-Martino and Robert Martino 39729 Pharmaceutical Industry: Regulatory Control and Impact on NMR SpectroscopyAndrea Ruggiero and Sarah K. Branch 41330 NMR Spectroscopy in the European and US PharmacopeiasHelen Corns and Sarah K. Branch 42531 NMR in Pharmaceutical ManufacturingEdwin Kellenbach and Paulo Dani 441Index 453
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