Metals in Cells

Inbunden, Engelska, 2013

2 390 kr

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Beskrivning

Over the last three decades a lot of research on the role of metals in biochemistry and medicine has been done. As a result many structures of biomolecules with metals have been characterized and medicinal chemistry studied the effects of metal containing drugs.This new book (from the EIBC Book Series) covers recent advances made by top researchers in the field of metals in cells [the “metallome”] and include: regulated metal ion uptake and trafficking, sensing of metals within cells and across tissues, and identification of the vast cellular factors designed to orchestrate assembly of metal cofactor sites while minimizing toxic side reactions of metals. In addition, it features aspects of metals in disease, including the role of metals in neuro-degeneration, liver disease, and inflammation, as a way to highlight the detrimental effects of mishandling of metal trafficking and response to "foreign" metals. With the breadth of our recently acquired understanding of metals in cells, a book that features key aspects of cellular handling of inorganic elements is both timely and important. At this point in our understanding, it is worthwhile to step back and take an expansive view of how far our understanding has come, while also highlighting how much we still do not know.The content from this book will publish online, as part of EIBC in December 2013, find out more about the Encyclopedia of Inorganic and Bioinorganic Chemistry, the essential online resource for researchers and students working in all areas of inorganic and bioinorganic chemistry.

Produktinformation

Utgivningsdatum:2013-09-27
Mått:224 x 287 x 31 mm
Vikt:1 901 g
Format:Inbunden
Språk:Engelska
Serie:EIC Books
Antal sidor:608
Förlag:John Wiley & Sons Inc
ISBN:9781119953234

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Prof. Robert A. Scott (Editor-in-Chief Encyclopedia of Inorganic and Bioinorganic Chemistry)Distinguished Research Professor, University of Georgia, USA.Prof. Valeria Culotta, Biochemistry and Molecular Biology Department, Joint Departmental Affiliations Environmental Health SciencesResearch in the Culotta lab focuses on the role of metal ions and oxygen radicals in biology and disease. Metal ions such as copper, iron and manganese are not only trace nutrients but can be quite toxic. One mechanism of toxicity is through generation of reactive oxygen species (ROS) that have been implicated in numerous human disorders from neurodegeneration to cancer to aging. Through molecular genetic approaches and high through-put genetic screens in yeast, we have identified a number genes and pathways that are involved in transition metal and reactive oxygen metabolism. Virtually all are well conserved throughout eukaryotes including humans. Our laboratory uses a combination of yeast, C. elegans and cell culture systems at the crossroads of bioinorganic chemistry, cell biology and molecular genetics.

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Contributors xiSeries Preface xixVolume Preface xxiPART 1: INTRODUCTION 1Mechanisms Controlling the Cellular Metal Economy 3Benjamin A. Gilston and Thomas V. O’HalloranPART 2: PROBING METALS AND CROSS TALK IN THE METALLOME 15 The Metallome 17Vadim N. Gladyshev and Yan ZhangCyanobacterial Models that Address Cross-Talk in Metal Homeostasis 39Carl J. Patterson, Rafael Pernil, Andrew W. Foster and Nigel J. RobinsonSparing and Salvaging Metals in Chloroplasts 51Crysten E. Blaby-Haas and Sabeeha S. MerchantFluorescent Probes for Monovalent Copper 65M. Thomas Morgan, Pritha Bagchi and Christoph J. FahrniFluorescent Zinc Sensors 85Amy E. Palmer, Jose G. Miranda and Kyle P. CarterX-Ray Fluorescence Microscopy 99James E. Penner-HahnPART 3: MOVING METALS IN CELLS 111Iron and Heme Transport and Trafficking 113Yvette Y. Yien and Barry H. PawIron in Plants 131Jessica B. Weng and Mary Lou GuerinotTransport of Nickel and Cobalt in Prokaryotes 145Thomas EitingerTransport Mechanism and Cellular Functions of Bacterial Cu(I)-ATPases 155Jose M. Arguello, Teresita Padilla-Benavides and Jessica M. CollinsCopper Transport in Fungi 163Simon Labbe, Jude Beaudoin and Raphael IoannoniStructural Biology of Copper Transport 175Adrian G. Flores, Christopher R. Pope and Vinzenz M. UngerZinc Transporters and Trafficking in Yeast 183Yi-Hsuan Wu and David J. EideCadmium Transport in Eukaryotes 195Nathan Smith, Wenzhong Wei and Jaekwon LeePART 4: METALS IN REGULATION 207Metal Specificity of Metallosensors 209Khadine A. Higgins and David P. GiedrocMetal Homeostasis and Oxidative Stress in Bacillus subtilis 225Zhen Ma and John D. HelmannRegulation of Manganese and Iron Homeostasis in the Rhizobia and Related α-Proteobacteria 237Mark R. O’BrianThe Iron Starvation Response in Saccharomyces cerevisiae 249Caroline C. Philpott and Pamela M. SmithHepcidin Regulation of Iron Homeostasis 265Clara Camaschella and Laura SilvestriNikR: Mechanism and Function in Nickel Homeostasis 277Michael D. Jones, Andrew M. Sydor and Deborah B. ZambleRegulation of Copper Homeostasis in Plants 289Marinus Pilon and Wiebke TapkenRegulation of Zinc Transport 301Taiho KambeSelenoproteins—Regulation 311Lucia A. Seale and Marla J. BerryPART 5: METALS IN CELLULAR DAMAGE AND DISEASE 321Metals in Bacterial Pathogenicity and Immunity 323Jennifer S. CavetManganese in Neurodegeneration 335Daiana Silva Avila, Robson Luiz Puntel, Felix Antunes Soares, Joao Batista Teixeira da Rocha and Michael AschnerIron Sequestration in Immunity 349Colin Correnti and Roland K. StrongMolecular Basis of Hemochromatosis 361Paul J. SchmidtCopper in Brain and Neurodegeneration 373Jeffrey R. Liddell, Ashley I. Bush and Anthony R. WhiteCopper Transporting ATPases in Mammalian Cells 395Nan Yang and Svetlana LutsenkoCopper in Immune Cells 409Karrera Y. Djoko, Maud E.S. Achard and Alastair G. McEwanSelenoenzymes and Selenium Trafficking: An Emerging Target for Therapeutics 421William Self and Sarah RosarioResistance Pathways for Metalloids and Toxic Metals 429Zijuan Liu, Christopher Rensing and Barry P. RosenPART 6: COFACTOR ASSEMBLY 443Fe–S Cluster Biogenesis in Archaea and Bacteria 445Harsimranjit K. Chahal, Jeff M. Boyd and F. Wayne OuttenMitochondrial Iron Metabolism and the Synthesis of Iron–Sulfur Clusters 473Andrew Dancis and Paul A. Lindahl[FeFe]-Hydrogenase Cofactor Assembly 491Eric M. Shepard, Amanda S. Byer, Eric S. Boyd, Kevin D. Swanson, John W. Peters and Joan B. Broderick[NiFe]-Hydrogenase Cofactor Assembly 507Basem Soboh and R. Gary SawersCopper in Mitochondria 517Katherine E. Vest and Paul A. CobineMo Cofactor Biosynthesis and Crosstalk with FeS 529Florian Bittner and Ralf R. MendelNitrogenase Cofactor Assembly 543Jared A. Wiig, Chi Chung Lee, Markus W. Ribbe and Yilin HuIndex 555