Nanotechnology and Regenerative Engineering

Cato T. Laurencin, Lakshmi S. Nair

"This book very nicely assembles the key considerations in the use of nanotechnology in tissue engineering, including topics of nanofabrication techniques, interactions of cells with nano-structured materials, applications of nanostructured scaffolds, and the regulatory FDA issues in the use of nanomaterials. …All topics are well–suited to the overall direction of the book."—Heungsoo Shin, Hanyang University, Korea"The strengths of this book are that it brings together the fields of bionanotechnology and tissue engineering to develop a single concise text which explains the state of the art in the field of regenerative medicine. For a non-expert or undergraduate it starts by providing information on the fundamentals of tissue engineering but quickly moves into more informative chapters focused on cellular responses toward nanostructured materials and emerging nanofabrication techniques and how they can be applied towards developing biomimetic scaffolds for tissue regeneration. Specific clinical areas are focused upon in detail making the text valuable to researchers working in these areas. Uniquely in comparison to many to many textbooks, there is a chapter on regulatory perspectives on nanostructured materials thus proving information on the route to the market and of course the barriers that exist therein. This is an excellent addition and provides valuable information at all levels- from explaining basic regulatory challenges to undergraduates to informing professors on the route to the market for technologies developed in their labs."—Professor Fergal O’Brien, Chair of Bioengineering & Regenerative Medicine, Royal College of Surgeons in Ireland & Trinity College Dublin"Langer in his inimitable style has given us an extraordinary overview of where we stand in the field of tissue engineering. …This book provides an excellent combination of the principles of biomaterials, bioengineering and biology. This is very hard to find and I highly recommend it."—Shanti Nair, Amrita University, India"It covers several important topics that are important to someone entering or working in the field."—Guillermo Ameer, Northwestern University, Evanston, Illinois, USA

• SECTION I Importance of Scaffolds in Tissue Regeneration. Tissue Engineering: The Therapeutic Strategy of the Twenty-First Century . From Microenvironment to Nanoenvironment: Ultrastructure and Function of . Extracellular Matrix. Functions and Requirements of Synthetic Scaffolds in Tissue Engineering. Microfabrication Techniques in Scaffold Development. SECTION II Effect of Nanostructures on Cellular Responses and Tissue Regeneration. Cell Response to Nanoscale Features and Its Implications in Tissue Regeneration: An Orthopedic Perspective. Surface Modification of Biomaterials at the Nanoscale: Biomimetic Scaffolds for Tissue Engineering Applications. SECTION III Promising Nanofabrication Techniques for Scaffolds to Support Tissue Regeneration. Electrospun Polymeric Nanofiber Scaffolds for Tissue Regeneration. Structure and Mechanical Properties of Electrospun Nanofibers and Nanocomposites. Electrospinning Techniques to Control Deposition and Structural Alignment of Nanofibrous Scaffolds for Cellular Orientation and Cytoskeletal Reorganization. Nanolithographic Techniques in Tissue Engineering. Designer Self-Assembling Peptide Scaffolds for Tissue Engineering and Regenerative Medicine. SECTION IV Applications of Nanostructured Scaffolds in Biology and Medicine. Nanotechnologies to Promote Skin Tissue Regeneration . Nanotechnologies for Neural Tissue Engineering . Nanotechnologies for Cardiovascular Tissue Engineering. Nanostructures for Musculoskeletal Tissue Engineering . SECTION V Regulatory Perspectives on Nanostructured Materials. Regulatory Process of Nanostructured Tissue Engineered Products. Index.