Omic Association Studies with R and Bioconductor

AvJuan R. González,Alejandro Cáceres

Inbunden, Engelska, 2019

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Beskrivning

After the great expansion of genome-wide association studies, their scientific methodology and, notably, their data analysis has matured in recent years, and they are a keystone in large epidemiological studies. Newcomers to the field are confronted with a wealth of data, resources and methods. This book presents current methods to perform informative analyses using real and illustrative data with established bioinformatics tools and guides the reader through the use of publicly available data. Includes clear, readable programming codes for readers to reproduce and adapt to their own data. Emphasises extracting biologically meaningful associations between traits of interest and genomic, transcriptomic and epigenomic data Uses up-to-date methods to exploit omic data Presents methods through specific examples and computing sessions Supplemented by a website, including code, datasets, and solutions

Produktinformation

Utgivningsdatum:2019-06-11
Mått:156 x 234 x 22 mm
Vikt:726 g
Format:Inbunden
Språk:Engelska
Antal sidor:376
Förlag:Taylor & Francis Ltd
ISBN:9781138340565

Utforska kategorier

Matematisk statistik inom Naturvetenskap och teknik
Biologi inom Naturvetenskap och teknik
Affärsapplikationer inom Data och IT

Mer om författaren

Juan R. González is an Associate Research Professor leading the Bioinformatics Research Group in Epidemiology at Barcelona Institute for Global Health. He has published extensively on methods and bioinformatics tools to detect structural variants from genomic data and to perform different types of omic association studies. Dr. González is the author of a large number of R and Bioconductor packages including state-of-the-art libraries such as SNPassoc or MAD that have been used to discover new susceptibility genetic factor for complex diseases. Alejandro Caceres is a Senior Statistician in the Bioinformatics Research Group in Epidemiology at Barcelona Institute for Global Health. He has large experience in developing new statistical methods to exploit genomic, transcriptomic and epigenomic data obtained from public repositories. Dr. Cáceres is the author of several R and Bioconductor packages that have been used, for instance, to study the role of polymorphic genomic inversions in complex diseases or to investigate how the downregulation of chromosome Y may affect age-related diseases.

Recensioner i media

"This book is a good tool for self-learning analytical strategies for omics data. It requires previous knowledge of R and focuses on getting things done...I think the book would be a good reference for masters or PhD students that have to perform their analysis and need a starting point. Also, for the practicing statistician working with omics data."- Victor Moreno, ISCB News, July 2020"Omic Association Studies with R and Bioconductor is an excellent tool book for those looking to have hands-on guidance to analyze multiomics datasets using established packages. The authors provide comprehensive examples of using genomic, transcriptomic, epigenomic, and exposomic data, as well as their integration, to generate biological hypotheses and explore individual heterogeneity."– Biometrics

Innehållsförteckning

1 Introduction 2 Case examples 3 Dealing with omic data in Bioconductor 4 Genetic association studies 5 Genomic variant studies 6 Adressing batch effects 7 Transcriptomic studies 8 Epigenomic studies 9 Exposomic analysis 10 Enrichment analysis 11 Multiomic data analysis