Professor Dr. Sc., Alevtina S. Medvedeva fields of research include organic and element organic synthesis based on acetylene derivatives; chemistry of heterocyclic compounds; chemistry of heteroatomic oxoalkens; addition reactions to unsaturated bonds; organic and supramolecular catalysis. Key achievements include new general methods of cascade assembly of polyfunctional heterocyclic compounds based on tandem and multicomponent reactions of heteroatomic α,β-acetylenic carbonyl compounds with nucleophiles that do not require metal catalysis. Development of new, effective synthetic methods of unknown or difficult to access, important heterocycles: functionalized imidazo[1,2-a]pyridines, pyrroles, 1,2,3-triazoles, 1,2-isoxazoles, pyrazoles, 2,3-dihydro-1H-1,4-diazepines, heterocyclic azidonitramines, acetylene 1,2-dihydropyridines, 3,4-dihydropyrimidine-2-(1H)-ones, 4H-pyran-2,6-dicarbaldehydes, 1,3,4- oxadiazoles, 1,3-dioxolanes, 1,3-thiazolidines, nitronyl nitroxides. Design of modern green approaches involving the reactions in water using heterogeneous and reusable supramolecular catalysts such as cyclodextrins or chitosan, microwave assistance, atom economy are preferable for the cascade synthesis of target heterocycles. High-performance, resource-economy technologies for the synthesis of non-steroidal medicines, possessing anti-inflammatory, pain-relieving and anti-pyretic effects, that are Piroxicam and Meloxicam, have been developed. New water soluble bioconjugate piroxicam—arabinogalactan sulfate and mechanocomposites of piroxicam with inorganic oxides or chitosan with improved solubility in water and biological activity have been prepared. Alexander V. Mareev graduated from Irkutsk State University, Chemistry Department in 2001 and then got a post graduate degree of Candidate of Chemical Sciences (PhD analogue) in 2004 at A. E. Favorsky Irkutsk Institute of Chemistry. His research interests include: development of new highly efficient domino reactions to assemble polyfunctional heterocyclic compounds based on silicon (germanium) containing propynals or their carbon analogues and 1,3-N,N-binucleophiles; chemical design of complicated heterocyclic systems with pharmacophore functions under biomimetic conditions; investigation of the rate and selectivity control of the domino reactions and self-assembling processes under microwave assistance and organic or supramolecular catalysis; search of new heterocyclic compounds that could be used as templates for organic synthesis, as fluorescent biomarkers, perspective materials for the optoelectronics and new efficient medicinal drugs.

• Introduction. Metal-Catalyzed Multicomponent Synthesis of Heterocycles from Activated Alkynes. Multicomponent Reactions of Activated Alkynes with Isonitriles. Highly Efficient Reactivity of Activated Alkynes in Multicomponent Synthesis of N-containing Heterocycles. Synthesis of Heterocycles via Multicomponent Reactions of Activated Acetylenes with C-,O-, S-, P-Nucleophiles. Activated Alkynes in Organocatalyzed Multicomponent Assembly of Polyfunctional Heterocycles. Multicomponent Synthesis of Spirocyclic Heterocycles from Activated Acetylenes. Metal-free Multicomponent Conversion of Si/Ge Alkynyl Carbonyl Compounds into Functionalized Heterocycles. Multicomponent Synthesis of Heterocycles via 1,3-Dipolar Cycloaddition to Electron-deficient Alkynes. Microwave-Assisted Multicomponent Reactions involving Activated Acetylenes and Nucleophiles for the Synthesis of Heterocycles. Application of multifunctional heterocycles in medicine chemistry and material science.

Professor Dr. Sc., Alevtina S. Medvedeva fields of research include organic and element organic synthesis based on acetylene derivatives; chemistry of heterocyclic compounds; chemistry of heteroatomic oxoalkens; addition reactions to unsaturated bonds; organic and supramolecular catalysis. Key achievements include new general methods of cascade assembly of polyfunctional heterocyclic compounds based on tandem and multicomponent reactions of heteroatomic α,β-acetylenic carbonyl compounds with nucleophiles that do not require metal catalysis. Development of new, effective synthetic methods of unknown or difficult to access, important heterocycles: functionalized imidazo[1,2-a]pyridines, pyrroles, 1,2,3-triazoles, 1,2-isoxazoles, pyrazoles, 2,3-dihydro-1H-1,4-diazepines, heterocyclic azidonitramines, acetylene 1,2-dihydropyridines, 3,4-dihydropyrimidine-2-(1H)-ones, 4H-pyran-2,6-dicarbaldehydes, 1,3,4- oxadiazoles, 1,3-dioxolanes, 1,3-thiazolidines, nitronyl nitroxides. Design of modern green approaches involving the reactions in water using heterogeneous and reusable supramolecular catalysts such as cyclodextrins or chitosan, microwave assistance, atom economy are preferable for the cascade synthesis of target heterocycles. High-performance, resource-economy technologies for the synthesis of non-steroidal medicines, possessing anti-inflammatory, pain-relieving and anti-pyretic effects, that are Piroxicam and Meloxicam, have been developed. New water soluble bioconjugate piroxicam—arabinogalactan sulfate and mechanocomposites of piroxicam with inorganic oxides or chitosan with improved solubility in water and biological activity have been prepared. Alexander V. Mareev graduated from Irkutsk State University, Chemistry Department in 2001 and then got a post graduate degree of Candidate of Chemical Sciences (PhD analogue) in 2004 at A. E. Favorsky Irkutsk Institute of Chemistry. His research interests include: development of new highly efficient domino reactions to assemble polyfunctional heterocyclic compounds based on silicon (germanium) containing propynals or their carbon analogues and 1,3-N,N-binucleophiles; chemical design of complicated heterocyclic systems with pharmacophore functions under biomimetic conditions; investigation of the rate and selectivity control of the domino reactions and self-assembling processes under microwave assistance and organic or supramolecular catalysis; search of new heterocyclic compounds that could be used as templates for organic synthesis, as fluorescent biomarkers, perspective materials for the optoelectronics and new efficient medicinal drugs.

• Introduction. Metal-Catalyzed Multicomponent Synthesis of Heterocycles from Activated Alkynes. Multicomponent Reactions of Activated Alkynes with Isonitriles. Highly Efficient Reactivity of Activated Alkynes in Multicomponent Synthesis of N-containing Heterocycles. Synthesis of Heterocycles via Multicomponent Reactions of Activated Acetylenes with C-,O-, S-, P-Nucleophiles. Activated Alkynes in Organocatalyzed Multicomponent Assembly of Polyfunctional Heterocycles. Multicomponent Synthesis of Spirocyclic Heterocycles from Activated Acetylenes. Metal-free Multicomponent Conversion of Si/Ge Alkynyl Carbonyl Compounds into Functionalized Heterocycles. Multicomponent Synthesis of Heterocycles via 1,3-Dipolar Cycloaddition to Electron-deficient Alkynes. Microwave-Assisted Multicomponent Reactions involving Activated Acetylenes and Nucleophiles for the Synthesis of Heterocycles. Application of multifunctional heterocycles in medicine chemistry and material science.

Professor Dr. Sc., Alevtina S. Medvedeva fields of research include organic and element organic synthesis based on acetylene derivatives; chemistry of heterocyclic compounds; chemistry of heteroatomic oxoalkens; addition reactions to unsaturated bonds; organic and supramolecular catalysis. Key achievements include new general methods of cascade assembly of polyfunctional heterocyclic compounds based on tandem and multicomponent reactions of heteroatomic α,β-acetylenic carbonyl compounds with nucleophiles that do not require metal catalysis. Development of new, effective synthetic methods of unknown or difficult to access, important heterocycles: functionalized imidazo[1,2-a]pyridines, pyrroles, 1,2,3-triazoles, 1,2-isoxazoles, pyrazoles, 2,3-dihydro-1H-1,4-diazepines, heterocyclic azidonitramines, acetylene 1,2-dihydropyridines, 3,4-dihydropyrimidine-2-(1H)-ones, 4H-pyran-2,6-dicarbaldehydes, 1,3,4- oxadiazoles, 1,3-dioxolanes, 1,3-thiazolidines, nitronyl nitroxides. Design of modern green approaches involving the reactions in water using heterogeneous and reusable supramolecular catalysts such as cyclodextrins or chitosan, microwave assistance, atom economy are preferable for the cascade synthesis of target heterocycles. High-performance, resource-economy technologies for the synthesis of non-steroidal medicines, possessing anti-inflammatory, pain-relieving and anti-pyretic effects, that are Piroxicam and Meloxicam, have been developed. New water soluble bioconjugate piroxicam—arabinogalactan sulfate and mechanocomposites of piroxicam with inorganic oxides or chitosan with improved solubility in water and biological activity have been prepared. Alexander V. Mareev graduated from Irkutsk State University, Chemistry Department in 2001 and then got a post graduate degree of Candidate of Chemical Sciences (PhD analogue) in 2004 at A. E. Favorsky Irkutsk Institute of Chemistry. His research interests include: development of new highly efficient domino reactions to assemble polyfunctional heterocyclic compounds based on silicon (germanium) containing propynals or their carbon analogues and 1,3-N,N-binucleophiles; chemical design of complicated heterocyclic systems with pharmacophore functions under biomimetic conditions; investigation of the rate and selectivity control of the domino reactions and self-assembling processes under microwave assistance and organic or supramolecular catalysis; search of new heterocyclic compounds that could be used as templates for organic synthesis, as fluorescent biomarkers, perspective materials for the optoelectronics and new efficient medicinal drugs.

• Introduction. Metal-Catalyzed Multicomponent Synthesis of Heterocycles from Activated Alkynes. Multicomponent Reactions of Activated Alkynes with Isonitriles. Highly Efficient Reactivity of Activated Alkynes in Multicomponent Synthesis of N-containing Heterocycles. Synthesis of Heterocycles via Multicomponent Reactions of Activated Acetylenes with C-,O-, S-, P-Nucleophiles. Activated Alkynes in Organocatalyzed Multicomponent Assembly of Polyfunctional Heterocycles. Multicomponent Synthesis of Spirocyclic Heterocycles from Activated Acetylenes. Metal-free Multicomponent Conversion of Si/Ge Alkynyl Carbonyl Compounds into Functionalized Heterocycles. Multicomponent Synthesis of Heterocycles via 1,3-Dipolar Cycloaddition to Electron-deficient Alkynes. Microwave-Assisted Multicomponent Reactions involving Activated Acetylenes and Nucleophiles for the Synthesis of Heterocycles. Application of multifunctional heterocycles in medicine chemistry and material science.