Predictive Methods for Genomics and Evolution

Towards a New Analytical Biology

Inbunden, Engelska, 2025

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Beskrivning

Innovative title providing a systematic account of new alignment-free methods in genomics and bioinformatics, emphasizing their potential to add predictive capabilities to address major and current questions in the science of biologyPredictive Methods for Genomics and Evolution provides a cohesive overview of major alignment-based and alignment-free methods in genomics and bioinformatics, primarily based on DNA/RNA. Throughout the book, contrasts between current conventional methods and novel alignment-free methods are presented and evaluated across a wide range of topics.Written by a team of experienced academics with significant research experience in the field, Predictive Methods for Genomics and Evolution discusses major topics including: Major unresolved problems in biology including the most fundamental concept of species, the nature of evolution and speciation, phylogenetic inference, pathogenicity, and the origin of lifeNovel interpretations of current hypotheses from a biological perspective with wide-ranging applications in bioinformatics and medicineInsights on the shift in the research status quo towards a wider application of more efficient alignment-free methodologies, fueled by the increased availability of data, deeper knowledge of DNA/RNA structure and powerful methods from the fields of machine learning and data science.Predictive Methods for Genomics and Evolution is an essential guide on the subject for professionals, academics, researchers, and students within the fields of genomics, evolutionary biology, phylogenetics and taxonomy, and computational biology and bioinformatics, as well as medical practitioners in related fields. A companion website for this text can be found here: bmc.memphis.edu/predBiology

Produktinformation

Utgivningsdatum:2025-10-17
Mått:176 x 252 x 21 mm
Vikt:771 g
Format:Inbunden
Språk:Engelska
Antal sidor:272
Förlag:John Wiley & Sons Inc
ISBN:9781394317424

Utforska kategorier

Biovetenskap inom Naturvetenskap och teknik

Mer om författaren

Max Garzon is Professor of computer science and bioinformatics at the University of Memphis, where he teaches both undergraduate and graduate courses in data science, neurocomputing, bioinformatics, foundations of computing and cyber ethics. Luis F. García is an Associate Professor at the National University of Colombia, where he teaches and advises both undergraduate and graduate students in evolution, molecular systematics, phylogenetics, genetics and computational biology. Alexander Colorado is a researcher and educator who has spent doctoral stays at Clemson University and the University of Alberta, Canada, and served as mentor in programs for aspiring young biologists in Colombia. His main research interest is the integrative taxonomy of black flies (Diptera: Simuliidae).

Innehållsförteckning

Preface xiAcknowledgments xiiiAcronyms xv1 What Is Biology? 11.1 DNA: Nature, Role, and Function 31.2 Hybridization Affinity 191.3 Summary 302 Genomes to Phenotypes, Environments, and Genomes 372.1 Phenotype Determination: The Conventional View 372.2 Environments and Autopoiesis 452.3 Phenotype Determination: An Alternative View 472.4 Summary 523 Species Definitions and Their Limitations 573.1 The Importance of the Concept of Species 573.2 Current Species Definitions 623.3 What Exactly Is a "Species"? 693.4 A Deeper Definition of "Species" 733.5 Summary 844 Speciation and Evolution 894.1 Darwinian Evolution 894.2 Neo-Darwinian Evolution: The Modern Synthesis 944.3 Speciation Processes 974.4 Summary 1085 From Genomes to Evolution 1135.1 From Genotypes to Phenotypes: Evolutionary Scale 1145.2 Is the Course of Evolution Predictable at the Macroscale? 1205.3 Is the Course of Evolution Predictable at the Lineage Scale? 1255.4 Summary 1346 Conventional Phylogenetics and Systematics 1396.1 DNA: The Thin Thread of Life 1406.2 Distance Methods versus Parsimony Analysis 1466.3 Probabilistic Methods and Evolutionary Models 1496.4 Case Study in Molecular Taxonomy: COI 1556.5 Summary 1657 New Approaches to Phylogenetics 1737.1 Phylogenetic Trees 1737.2 Phylogenetic Tree Assessment 1777.3 Phylogenetic Hypotheses Based on Deep DNA Structure 1787.4 Summary 1808 About the Origin of Life 1858.1 Theories of the Origin of Life on Earth: From Creationism to Panspermia 1858.2 Complex Systems: A Holistic Approach 1888.3 A Case Study: Polytene Chromosomes in Black Flies 1958.4 Summary 2109 Toward an Analytical Biology 2179.1 What Is Data Science (DS)? 2189.2 What Is Machine Learning (ML)? 2249.3 Causality vs. Correlation 2269.4 What Is Artificial Intelligence (AI)? 2289.5 The Natural Intelligence of DNA and Biological Organisms 2299.6 Summary 23110 Appendices 23510.1 Genotypes 23510.2 Standard Biological Taxonomies 23510.3 Divergence in Black Flies 23810.4 Software 244Bibliography 244Index 245