Weighted Network Analysis

Applications in Genomics and Systems Biology

AvSteve Horvath

Inbunden, Engelska, 2011

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Beskrivning

High-throughput measurements of gene expression and genetic marker data facilitate systems biologic and systems genetic data analysis strategies. Gene co-expression networks have been used to study a variety of biological systems, bridging the gap from individual genes to biologically or clinically important emergent phenotypes.

Produktinformation

Utgivningsdatum:2011-05-04
Mått:155 x 235 x 30 mm
Vikt:834 g
Format:Inbunden
Språk:Engelska
Antal sidor:421
Upplaga:2011
Förlag:Springer-Verlag New York Inc.
ISBN:9781441988188

Utforska kategorier

Biovetenskap inom Naturvetenskap och teknik
Medicinsk genetik inom Medicin

Innehållsförteckning

Preface.- Networks and fundamental concepts.- Approximately factorizable networks.- Different type of network concepts.- Adjacency functions and their topological effects.- Correlation and gene co-expression networks.- Geometric interpretation of correlation networks using the singular value decomposition.- Constructing networks from matrices.- Clustering Procedures and module detection.- Evaluating whether a module is preserved in another network.- Association and statistical significance measures.- Structural equation models and directed networks.- Integrated weighted correlation network analysis of mouse liver gene expression data.- Networks based on regression models and prediction methods.- Networks between categorical or discretized numeric variables.- Networks based on the joint probability distribution of random variables.- Index.