P2 Nucleotide Receptors

"This book is...very timely...essential reading...really useful and encyclopaedic information."-Journal of Chemical Neuroanatomy

• I. Historical Perspectives of P2 Nucleotide Receptors.- 1 · History of Extracellular Nucleotides and Their Receptors.- II. Pharmacological and Molecular Characterization of P2 Nucleotide Receptors.- 2 · P2X Receptors: Cloned and Expressed.- 3 · The Cloning and Expression of G Protein-Coupled P2Y Nucleotide Receptors.- 4 · Structure Activity Relationships of P2 Receptor Agonists and Antagonists.- 5 · Pharmacological Selectivities of Molecularly Defined Subtypes of P2Y Receptors.- 6 · P2 Receptor Modeling and Identification of Ligand Binding Sites.- III. Mechanisms of P2 Nucleotide Receptor Action.- 7 · Nucleotide Receptors Coupling to the Phospholipase C Signaling Pathway.- 8 · Cyclic AMP and Tyrosine Kinase Cascades in the Regulation of Cellular Function by P2Y Nucleotide Receptors.- 9 · Characteristics of Ligand-Gated Ion Channel P2 Nucleotide Receptors.- 10 · Cell Responses Initiated by Ecto-Kinases.- IV. Physiological Roles for P2 Nucleotide Receptors.- 11 · Functions of Extracellular Nucleotides in Peripheral and Central Neuronal Tissues.- 12 · Role of Purinoceptors in the Regulation of Lung Surfactant Secretion.- 13 · The Role of Nucleotide Receptors in the Cardiovascular System.- 14 · Physiological Roles for P2 Receptors in Platelets, Visceral Smooth Muscle, and the Immune and Endocrine Systems.- 15 · Therapeutic Applications for Nucleotides in Lung Disease.- V. Future Vistas.- 16 · Future Directions in P2 Receptor Research.